18 Questions
What percentage of the lens is composed of protein at the molecular level?
90%
What is the primary function of alpha-crystallin in the lens?
To act as a chaperone and protect target proteins from stress
What determines the specific patterns of twisting and folding of proteins in the lens?
The sequence of amino acids in the protein
Which technique is most commonly used to determine the 3D structure of crystallin proteins?
X-ray crystallography
What is a common characteristic shared by alpha, beta, and gamma crystallin proteins?
They are all globular proteins with different isoforms
What is the significance of the shared characteristics among alpha, beta, and gamma crystallin proteins?
They are crucial for our understanding of the normal and abnormal lens
What is the primary reason for the transparent nature of the lens?
The structural regularity of crystallins at the atomic and molecular level
What is the characteristic of the aggregate formed by gamma crystallin?
Monomer with two self-associating domains
What is the effect of disturbed packing of crystallins on light transmission?
It reduces light transmission
What is the characteristic of the secondary structure of alpha crystallin?
Mostly alpha helices
What is the reason for the high density of crystallins in lens cells?
The compact globular structure of crystallins
What is the effect of the presence of enough crystallins in lens cells?
They are packed together at high density
What is the role of α-crystallin in maintaining lens transparency?
It prevents protein aggregation by functioning as a molecular chaperone
What is the characteristic of the dynamic quaternary structure of α-crystallin?
It is highly flexible and undergoes continuous exchange of subunits
What is the advantage of using contrast variation in Small Angle Neutron Scattering (SANS)?
It enables the investigation of the location of target protein binding with high precision
What is the characteristic of α-crystallin aggregates?
They are polydisperse and have different sizes
What is the function of α-crystallin in response to denatured proteins?
It binds to the denatured proteins and prevents their aggregation
What is the molecular weight of α-crystallin?
800 kDa
This quiz covers the properties and characteristics of globular proteins, including their structure, mechanisms, and functions in the body. Learn about alpha helices, beta sheets, domains, and more. Test your knowledge of protein biology!
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