Protein Secretion Pathways Quiz
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Questions and Answers

Which secretion system must transport proteins unfolded prior to outer membrane transport?

  • T4SS
  • T1SS
  • T3SS
  • T5SS (correct)
  • Which secretion system can transport proteins across an additional host cell membrane, delivering them directly to the cytosol of a target cell?

  • T1SS
  • T4SS
  • T6SS (correct)
  • T2SS
  • What is a common feature of the T2SS, T5SS, T3SS, and T4SS in terms of protein secretion?

  • They all require proteins to be unfolded prior to secretion.
  • They all contain periplasm-spanning channels. (correct)
  • They all secrete proteins in a one-step process.
  • They all use the Sec pathway for protein transport.
  • Which pathway can initially transport proteins that are folded in the periplasm before being secreted?

    <p>Sec pathway</p> Signup and view all the answers

    Which protein secretion system secretes folded substrates?

    <p>T2SS</p> Signup and view all the answers

    What distinguishes the autotransporters of the T5SS from other systems like T2SS and T6SS?

    <p>They must be unfolded before outer membrane transport.</p> Signup and view all the answers

    What type of cell differentiation may proinflammatory pathobionts induce to increase mucosal defenses against enteric pathogens?

    <p>TH17</p> Signup and view all the answers

    Which signaling molecules, when combined, promote TH17 cell evolution over time?

    <p>TGFβ and IL-6</p> Signup and view all the answers

    Disruptions to the microbiota can potentially affect infection outcomes by altering which mechanisms?

    <p>Colonization resistance</p> Signup and view all the answers

    Which dietary component can alter the community structure of the microbiota through the production of short-chain fatty acids (SCFAs)?

    <p>Carbohydrates</p> Signup and view all the answers

    Which microbial metabolites can bind to the G-protein-coupled receptor GPR43 and stimulate antimicrobial peptides?

    <p>Short-chain fatty acids (SCFAs)</p> Signup and view all the answers

    How do SCFAs inhibit the growth of Salmonella?

    <p>By acidifying the cytoplasm</p> Signup and view all the answers

    How does Yersinia evade host immune response?

    <p>By injecting TIR into host membrane</p> Signup and view all the answers

    Which mechanism is employed by Klebsiella pneumoniae to avoid phagocytosis?

    <p>Forming a polysaccharide capsule</p> Signup and view all the answers

    What is the role of TIR in the context of Entero-Pathogenic E. coli?

    <p>Acts as a receptor for bacterial surface protein Intimin</p> Signup and view all the answers

    How does Effector mimicry of host proteins contribute to bacterial survival?

    <p>Facilitates resistance to antimicrobial peptides</p> Signup and view all the answers

    Which feature of Klebsiella pneumoniae contributes to its resistance to serum and phagocytosis?

    <p>Forming a polysaccharide capsule</p> Signup and view all the answers

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