Protein Secretion Pathways Quiz

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Which secretion system must transport proteins unfolded prior to outer membrane transport?

T4SS

T1SS

T3SS

T5SS (correct)

Which secretion system can transport proteins across an additional host cell membrane, delivering them directly to the cytosol of a target cell?

T1SS

T4SS

T6SS (correct)

T2SS

What is a common feature of the T2SS, T5SS, T3SS, and T4SS in terms of protein secretion?

They all require proteins to be unfolded prior to secretion.

They all contain periplasm-spanning channels. (correct)

They all secrete proteins in a one-step process.

They all use the Sec pathway for protein transport.

Which pathway can initially transport proteins that are folded in the periplasm before being secreted?

Sec pathway Signup and view all the answers

Which protein secretion system secretes folded substrates?

T2SS Signup and view all the answers

What distinguishes the autotransporters of the T5SS from other systems like T2SS and T6SS?

They must be unfolded before outer membrane transport. Signup and view all the answers

What type of cell differentiation may proinflammatory pathobionts induce to increase mucosal defenses against enteric pathogens?

TH17 Signup and view all the answers

Which signaling molecules, when combined, promote TH17 cell evolution over time?

TGFβ and IL-6 Signup and view all the answers

Disruptions to the microbiota can potentially affect infection outcomes by altering which mechanisms?

Colonization resistance Signup and view all the answers

Which dietary component can alter the community structure of the microbiota through the production of short-chain fatty acids (SCFAs)?

Carbohydrates Signup and view all the answers

Which microbial metabolites can bind to the G-protein-coupled receptor GPR43 and stimulate antimicrobial peptides?

Short-chain fatty acids (SCFAs) Signup and view all the answers

How do SCFAs inhibit the growth of Salmonella?

By acidifying the cytoplasm Signup and view all the answers

How does Yersinia evade host immune response?

By injecting TIR into host membrane Signup and view all the answers

Which mechanism is employed by Klebsiella pneumoniae to avoid phagocytosis?

Forming a polysaccharide capsule Signup and view all the answers

What is the role of TIR in the context of Entero-Pathogenic E. coli?

Acts as a receptor for bacterial surface protein Intimin Signup and view all the answers

How does Effector mimicry of host proteins contribute to bacterial survival?

Facilitates resistance to antimicrobial peptides Signup and view all the answers

Which feature of Klebsiella pneumoniae contributes to its resistance to serum and phagocytosis?