Protein Secretion Pathways Quiz
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Questions and Answers

Which secretion system must transport proteins unfolded prior to outer membrane transport?

  • T4SS
  • T1SS
  • T3SS
  • T5SS (correct)

Which secretion system can transport proteins across an additional host cell membrane, delivering them directly to the cytosol of a target cell?

  • T1SS
  • T4SS
  • T6SS (correct)
  • T2SS

What is a common feature of the T2SS, T5SS, T3SS, and T4SS in terms of protein secretion?

  • They all require proteins to be unfolded prior to secretion.
  • They all contain periplasm-spanning channels. (correct)
  • They all secrete proteins in a one-step process.
  • They all use the Sec pathway for protein transport.

Which pathway can initially transport proteins that are folded in the periplasm before being secreted?

<p>Sec pathway (D)</p> Signup and view all the answers

Which protein secretion system secretes folded substrates?

<p>T2SS (B)</p> Signup and view all the answers

What distinguishes the autotransporters of the T5SS from other systems like T2SS and T6SS?

<p>They must be unfolded before outer membrane transport. (C)</p> Signup and view all the answers

What type of cell differentiation may proinflammatory pathobionts induce to increase mucosal defenses against enteric pathogens?

<p>TH17 (C)</p> Signup and view all the answers

Which signaling molecules, when combined, promote TH17 cell evolution over time?

<p>TGFβ and IL-6 (B)</p> Signup and view all the answers

Disruptions to the microbiota can potentially affect infection outcomes by altering which mechanisms?

<p>Colonization resistance (D)</p> Signup and view all the answers

Which dietary component can alter the community structure of the microbiota through the production of short-chain fatty acids (SCFAs)?

<p>Carbohydrates (C)</p> Signup and view all the answers

Which microbial metabolites can bind to the G-protein-coupled receptor GPR43 and stimulate antimicrobial peptides?

<p>Short-chain fatty acids (SCFAs) (C)</p> Signup and view all the answers

How do SCFAs inhibit the growth of Salmonella?

<p>By acidifying the cytoplasm (C)</p> Signup and view all the answers

How does Yersinia evade host immune response?

<p>By injecting TIR into host membrane (C)</p> Signup and view all the answers

Which mechanism is employed by Klebsiella pneumoniae to avoid phagocytosis?

<p>Forming a polysaccharide capsule (B)</p> Signup and view all the answers

What is the role of TIR in the context of Entero-Pathogenic E. coli?

<p>Acts as a receptor for bacterial surface protein Intimin (C)</p> Signup and view all the answers

How does Effector mimicry of host proteins contribute to bacterial survival?

<p>Facilitates resistance to antimicrobial peptides (B)</p> Signup and view all the answers

Which feature of Klebsiella pneumoniae contributes to its resistance to serum and phagocytosis?

<p>Forming a polysaccharide capsule (A)</p> Signup and view all the answers

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