36 Questions
What is the fate of excess and unwanted proteins in the body?
They are degraded to amino acids
Which amino acid is the major NH2-group donor for the synthesis of non-essential amino acids?
Glutamate
What is the first step in the catabolism of amino acids?
Removal of the NH2 group
Which vitamin is needed for the transamination of amino acids?
Vitamin B6 in the form of pyridoxal phosphate
Which enzyme catalyzes the reaction of transferring NH2 from majority of the amino acids to α-ketoglutarate?
Glutamate dehydrogenase
What activates glutamate dehydrogenase, the enzyme involved in the oxidative deamination of glutamate?
ADP/GDP
Which enzyme is the rate-limiting enzyme in the urea cycle?
Carbamoyl phohphate synthetase-I
Where does the conversion of ammonia into urea take place?
Mitochondria
Which amino acids are classified as both glucogenic and ketogenic?
Tyrosine, isoleucine, phenylalanine, and tryptophan
Which intermediates can the carbon skeleton of amino acids be converted into?
Pyruvate and acetyl CoA
What are the genetic defects in amino acid metabolism caused by?
Mutations in the genes of the enzymes involved
Which condition results from mutations in the genes of the enzymes involved in amino acid metabolism?
Mental retardation and developmental disabilities
Which of the following amino acids are only ketogenic and not glucogenic?
Leucine and lysine
What is required in some places for the detection of genetic defects in amino acid metabolism in newborns?
Neonatal screening
Which of the following is an important genetic defect in amino acid metabolism?
PKU
What is the major transaminase involved in transamination of amino acids?
Alanine aminotransferase (ALT)
Which amino acid participates in transamination along with threonine?
Lysine
Which enzyme catalyzes the oxidative deamination of glutamate?
Glutamate dehydrogenase
Which amino acid is only ketogenic and not glucogenic?
Leucine
Which of the following is a precursor required for the urea cycle?
NH3
Which enzyme is the rate-limiting enzyme in the urea cycle?
Carbamoyl phosphate synthetase-I
Which of the following amino acids can be converted into acetoacetate or acetyl CoA?
Tyrosine
Which amino acid is classified as both glucogenic and ketogenic?
Phenylalanine
Which condition results from mutations in the genes of the enzymes involved in amino acid metabolism?
PKU
What activates glutamate dehydrogenase, the enzyme involved in the oxidative deamination of glutamate?
ADP/GDP
What is the fate of excess and unwanted proteins in the body?
Converted into urea
Which of the following is a common result of metabolic defects in amino acid metabolism?
Mental retardation
Which vitamin is needed for the transamination of amino acids?
Vitamin B6
What is the first step in the catabolism of amino acids?
Removal of the NH2 group
Which enzyme catalyzes the transfer of NH2 from amino acids to α-ketoglutarate?
Aminotransferases
What is the major NH2-group donor for the synthesis of non-essential amino acids?
Glutamate
Which vitamin is needed in the form of pyridoxal phosphate for the transamination of amino acids?
Vitamin B6
What is the major fate of excess and unwanted proteins in the body?
Degraded to amino acids
Which vitamin is required for transamination of amino acids?
Vitamin B6
What is the first step in the catabolism of amino acids?
Removal of the NH2 group
What is the major NH2-group donor for the synthesis of non-essential amino acids?
Glutamate
Test your knowledge of protein metabolism and amino acid turnover with this quiz. Explore the synthesis of non-essential amino acids, the body's amino acid pool, and the constant turnover of body proteins. See how much you know about the intricate processes of amino acid metabolism.
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