10 Questions
Which of the following proteins promotes lamellipodia and filopodia formation?
Rho, Rac, Cdc42
Microtubules are inherently unstable unless they____.
bind to cap proteins
Most microtubules are made up of 13 ___________ that are linear chains of ____and _____ dimers.
protofilaments; alpha and beta tubulin
Shown below is a diagram of a centrosome and associated microtubules. What is the identity of the structure in red, indicated by the black dashed arrow?
gamma-tubulin ring complex
At the leading edge of a cell, ARP proteins help form new branches on actin filaments to push the leading edge forward using the force of the polymerization, as shown in the figure below. What type of structure is being formed?
lamellipodium
Which of the following motor proteins has one head domain, moves along actin toward the plus end, and is found in all cell types?
myosin-I
Which end of a microtubule assembles more rapidly?
(+) end.
The absence of ADP and ATP causes______.
tighly attaches the myosin head to the actin filament.
Calcium is released from the___upon t-tubule activation.
sarcoplasmic reticulum
Which of the following images shows microtubules? A=left, B=middle, C=right
B
Study Notes
Microtubules and Cell Motility
- ARP proteins promote lamellipodia and filopodia formation at the leading edge of a cell.
- Microtubules are inherently unstable unless they are capped at their plus end.
- Most microtubules are made up of 13 protofilaments that are linear chains of α-tubulin and β-tubulin dimers.
- The structure in red, indicated by the black dashed arrow in the diagram, is a centriole.
- ARP proteins help form new branches on actin filaments to push the leading edge forward using the force of polymerization.
- The type of structure being formed at the leading edge is lamellipodia or filopodia.
- The motor protein that has one head domain, moves along actin toward the plus end, and is found in all cell types is Myosin I.
- The plus end of a microtubule assembles more rapidly.
- The absence of ADP and ATP causes microtubule depolymerization.
- Calcium is released from the sarcoplasmic reticulum upon t-tubule activation.
- Image C (right) shows microtubules.
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