Questions and Answers
What is the nucleus-to-cytoplasm ratio of a Pronormoblast?
What does the cytoplasm of a Pronormoblast look like?
Dark blue due to high concentration of ribosomes.
What begins during the cellular activity of a Pronormoblast?
Globin production.
What is the length of time for the Rubriblast stage?
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What characterizes the nucleus of a Basophilic Normoblast?
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How does the cytoplasm of a Prorubicyte appear when stained?
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What is the nucleus-to-cytoplasm ratio of a Polychromatic Normoblast?
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What is seen during the development of a Rubricyte?
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How long does hemoglobin synthesis take in a Rubricyte?
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What is the nucleus like in an Orthochromic Normoblast?
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What color indicates nearly complete hemoglobin production in a Metrubricyte?
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What is the approximate time for the Metrubricyte stage?
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Does a Polychromatic Erythrocyte or reticulocyte have a nucleus?
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What color characterizes a Reticulocyte?
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What is true about an Erythrocyte's nucleus?
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Describe the appearance of an Erythrocyte.
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Study Notes
Pronormoblast (Rubriblast)
- Large nucleus occupies significant cell volume with a nuclear-to-cytoplasmic (N:C) ratio of 8:1.
- Nucleus is round to oval, containing one or two nucleoli and purple-red chromatin that is mostly open.
Cytoplasm Characteristics of Pronormoblast
- Dark blue cytoplasm due to high ribosome concentration.
- Potential visibility of the Golgi complex as a pale, unstained area adjacent to the nucleus.
- May exhibit small tufts of irregular cytoplasm along the membrane perimeter.
Cellular Activity of Pronormoblast
- Initiates globin production as part of the cellular activity.
Duration of Pronormoblast Stage
- Life span of the rubriblast is slightly greater than 24 hours.
Basophilic Normoblast (Prorubricyte)
- Chromatin begins to condense, forming clumps on the nuclear membrane and some in the interior.
- N:C ratio decreases to less than 6:1 with chromatin staining deep purple-red; nucleoli may still be present.
Cytoplasm Characteristics of Prorubricyte
- Cytoplasm appears darker, richer blue when stained compared to the pronormoblast.
Polychromatic Normoblast (Rubricyte)
- Chromatin shows variation, remaining open early in the stage but becomes condensed by the end.
- N:C ratio is approximately 4:1, with a significant reduction in nuclear diameter due to chromatin condensation.
Cytoplasm Characteristics of Rubricyte
- First stage where pink color associated with stained hemoglobin becomes visible.
- Cytoplasmic color is a murky gray-blue due to a mixture of pink and blue, indicating reduced RNA.
Cellular Activity of Rubricyte
- Increased hemoglobin synthesis occurs over approximately 30 hours.
Orthochromic Normoblast (Metarubricyte)
- Chromatin is completely condensed at this stage.
Cytoplasm Characteristics of Metarubricyte
- Notable increase in salmon-pink coloration, reflecting nearly complete hemoglobin production.
Duration of Metarubricyte Stage
- This stage lasts about 48 hours.
Polychromatic Erythrocyte (Reticulocyte)
- Characterized by the absence of a nucleus.
Cytoplasm Characteristics of Reticulocyte
- Salmọn-pink in coloration, indicative of development.
Erythrocyte
- No nucleus is present in mature erythrocytes.
Characteristics of Erythrocyte
- Biconcave disc shape with a salmon-pink staining and a central pale area, facilitating gas exchange.
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Description
This quiz features flashcards focused on the structure and characteristics of pronormoblasts, specifically highlighting their nuclei and cytoplasmic features. Perfect for students studying hematology or cell biology, these cards will enhance your understanding of immature red blood cells.
