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Questions and Answers
What type of tissue is primarily formed during the early part of the proliferative phase?
What type of tissue is primarily formed during the early part of the proliferative phase?
- Scar tissue
- Fibrous tissue
- Granulation tissue (correct)
- Epithelial tissue
Which of the following is NOT produced by fibroblasts during the proliferative phase?
Which of the following is NOT produced by fibroblasts during the proliferative phase?
- Angiogenesis
- Neutrophils (correct)
- Myofibroblasts
- Ground substance
What is one of the roles of myofibroblasts during the wound healing process?
What is one of the roles of myofibroblasts during the wound healing process?
- Enhance vascular permeability
- Increase oxidative stress in the wound environment
- Contribute to wound contraction (correct)
- Promote collagen breakdown
The proliferative phase lasts for approximately how many weeks?
The proliferative phase lasts for approximately how many weeks?
What characteristic change occurs to the tensile strength of the wound towards the end of the proliferative phase?
What characteristic change occurs to the tensile strength of the wound towards the end of the proliferative phase?
Flashcards
Proliferative Phase
Proliferative Phase
The initial stage of wound healing, lasting approximately 3 to 4 weeks, where the body begins to repair damaged tissue.
Fibroblasts
Fibroblasts
Specialized cells that produce collagen and other components of the extracellular matrix, playing a key role in tissue rebuilding.
Angiogenesis
Angiogenesis
The formation of new blood vessels, crucial for supplying oxygen and nutrients to the healing wound.
Granulation Tissue
Granulation Tissue
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Myofibroblasts
Myofibroblasts
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Study Notes
Proliferation Phase of Wound Healing
- Starts around day 3 and lasts 2-4 weeks.
- Primarily driven by fibroblast activity, creating:
- Ground substance (e.g., glycosaminoglycans, proteoglycans).
- Collagen.
- Angiogenesis (new blood vessel formation).
- Re-epithelialization (skin cell regeneration).
- Early phase tissue is called granulation tissue, appearing pink and granular.
- Later phase strengthens wound due to increased collagen synthesis by fibroblasts.
- Some fibroblasts become myofibroblasts, which contract to close the wound.
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