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Proliferation Phase of Wound Healing

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Questions and Answers

What type of tissue is primarily formed during the early part of the proliferative phase?

Scar tissue

Fibrous tissue

Granulation tissue (correct)

Epithelial tissue

Which of the following is NOT produced by fibroblasts during the proliferative phase?

Angiogenesis

Neutrophils (correct)

Myofibroblasts

Ground substance

What is one of the roles of myofibroblasts during the wound healing process?

Enhance vascular permeability

Increase oxidative stress in the wound environment

Contribute to wound contraction (correct)

Promote collagen breakdown

The proliferative phase lasts for approximately how many weeks?

<p>2-4 weeks (C)</p> Signup and view all the answers

What characteristic change occurs to the tensile strength of the wound towards the end of the proliferative phase?

<p>It increases due to collagen synthesis (D)</p> Signup and view all the answers

Flashcards

Proliferative Phase

The initial stage of wound healing, lasting approximately 3 to 4 weeks, where the body begins to repair damaged tissue.

Fibroblasts

Specialized cells that produce collagen and other components of the extracellular matrix, playing a key role in tissue rebuilding.

Angiogenesis

The formation of new blood vessels, crucial for supplying oxygen and nutrients to the healing wound.

Granulation Tissue

A type of connective tissue that forms during the proliferative phase, characterized by its pink, granular appearance.

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Myofibroblasts

Modified fibroblasts that possess contractile properties, helping to draw wound edges together.

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Study Notes

Proliferation Phase of Wound Healing

Starts around day 3 and lasts 2-4 weeks.
Primarily driven by fibroblast activity, creating:
- Ground substance (e.g., glycosaminoglycans, proteoglycans).
- Collagen.
- Angiogenesis (new blood vessel formation).
- Re-epithelialization (skin cell regeneration).
Early phase tissue is called granulation tissue, appearing pink and granular.
Later phase strengthens wound due to increased collagen synthesis by fibroblasts.
Some fibroblasts become myofibroblasts, which contract to close the wound.

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Description

Explore the details of the proliferation phase of wound healing, which begins around day 3 and can last 2-4 weeks. Learn about the vital roles fibroblasts play in creating collagen, angiogenesis, and re-epithelialization. Understand the transformation of granulation tissue and the effects of myofibroblasts on wound contraction.