Prinivil Flashcards

Study Notes

Prinivil Overview

Generic name: Lisinopril
Class: Antihypertensive medication

Dosage Forms

Available as tablets in dosages: 2.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, 40 mg

Indications

Primarily used for hypertension
Additionally indicated for renal impairment
Management of congestive heart failure (CHF)
Treatment of hemodynamically stable patients post-acute myocardial infarction within 24 hours

Dosing Information

Normal starting dose: 20-40 mg per day in a single daily dose
Initial dosing for hypertension: 10 mg once daily, with adjustments based on blood pressure response
For patients with renal impairment: dose of 10 mg after 48 hours, >10 mg once daily for 6 weeks; start with 2.5 mg if low blood pressure is present

Mechanism of Action

Suppresses the renin-angiotensin-aldosterone system
As an ACE inhibitor, reduces the synthesis of angiotensin II, a potent vasoconstrictor
Decreased angiotensin II leads to lower aldosterone release, resulting in reduced sodium and water reabsorption and decreased plasma volume
Degrades bradykinin, which is a vasodilator

Pharmacokinetics

Peak serum levels achieved in about 7 hours
Half-life of the medication is approximately 12 hours
Not metabolized; primarily excreted through urine

Drug Interactions

Effect decreased with indomethacin; may increase cough with capsaicin
Allopurinol raises risk of hypersensitivity reactions
Decreases lithium elimination and may cause potassium-related issues such as hyperkalemia
Can potentiate effects of oral antidiabetics or insulin

Contraindications and Precautions

Contraindicated in patients with a history of angioedema related to ACE inhibitors
Caution required in patients with renal impairment and those on potassium-sparing drugs
Risk of hypoglycemia in patients using oral antidiabetics or insulin
Pregnancy category D: Avoid use during pregnancy due to risks
Rare complications include cholestatic jaundice or hepatitis

Adverse Effects

Common side effects: dizziness, headache, fatigue, cough, diarrhea

Patient Consultation Points

Can be taken with or without food
Do not stop the medication without consulting a physician
Avoid over-the-counter cough, cold, or allergy medications
Refrain from salt substitutes that contain potassium
Store in a cool, dry location
If a dose is missed, take it as soon as possible unless close to the next dose; do not double dose
Contact a physician if side effects persist or if swelling occurs

Description

Test your knowledge of Prinivil, a generic drug name for Lisinopril. This quiz includes definitions of its drug class, dosage forms, and medical indications. Perfect for those studying pharmacology or preparing for medical examinations.

Prinivil Flashcards

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Questions and Answers

What is the generic name for Prinivil?

What drug class does Prinivil belong to?

What are the dosage forms for Prinivil?

Prinivil is indicated for treating __________.

What is the normal starting dose for Prinivil?

Dosing in hypertension patients usually starts at _____ mg once a day initially.

What is the mechanism of action for Prinivil?

How long does it take to reach peak serum levels of Prinivil?

What is the half-life of Prinivil?

Prinivil is metabolized in the liver.

What is one drug interaction associated with Prinivil?

Which of the following is a contraindication for Prinivil?

Common adverse effects of Prinivil include __________.

Match the following patient consultations with their advice: