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Questions and Answers
Which organ is the primary site for drug metabolism?
Which organ is the primary site for drug metabolism?
What are the two phases into which the metabolic process is divided?
What are the two phases into which the metabolic process is divided?
What factors can affect drug metabolism?
What factors can affect drug metabolism?
What is the Hepatic First Pass Effect?
What is the Hepatic First Pass Effect?
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What do Phase I reactions involve?
What do Phase I reactions involve?
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Study Notes
Principles of Drug Action
- Three phases of drug activity: Pharmaceutical, Pharmacokinetic, and Pharmacodynamic
Pharmaceutical Phase
- Involves solid dosage form
- Drug goes through dissolution and disintegration processes
Pharmacokinetic Phase
- Consists of four stages: Absorption, Distribution, Metabolism, and Excretion
Absorption
- Movement of drug across membranes
- Types of absorption:
- Filtration
- Simple Diffusion
- Facilitated Diffusion
- Active Transport
- Endocytosis
- Exocytosis
- Factors affecting absorption:
- pH
- Routes of Administration
- Dosage form
- Blood flow
- Surface area
- Solubility
- Drug Concentration
- Presence of Food in the Stomach
Distribution
- Transportation of drug in body fluids to various tissues
- Factors affecting distribution:
- Blood flow
- Binding to Plasma Protein
- Tissue Binding
- Lipid Solubility
- Distribution barriers:
- Blood Brain Barrier
- Placenta
- Lipid Solubility of the Drug
Metabolism
- Process that chemically inactivates a drug
- Converts drug to a more water-soluble compound for excretion
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Description
Test your knowledge of the physiological and other processes governing drug action. Explore topics such as pharmaceutical processes, pharmacokinetics, and pharmacodynamics.
