Principles of Drug Action Quiz
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Questions and Answers

Which organ is the primary site for drug metabolism?

  • Intestinal mucosa
  • Lungs
  • Liver (correct)
  • Plasma

What are the two phases into which the metabolic process is divided?

  • Primary Phase and Secondary Phase
  • Phase 1 and Phase 2 (correct)
  • Early Phase and Late Phase
  • Initial Phase and Final Phase

What factors can affect drug metabolism?

  • Age, gender, diet, environment, disease, other drugs (correct)
  • Geographic location, occupation, income level
  • Blood type, hair color, height, weight
  • Exercise habits, social habits, education level

What is the Hepatic First Pass Effect?

<p>Metabolism of a drug during its first pass through the liver before reaching general circulation (D)</p> Signup and view all the answers

What do Phase I reactions involve?

<p>Oxidation, reduction, or hydrolysis of the parent drug (D)</p> Signup and view all the answers

Study Notes

Principles of Drug Action

  • Three phases of drug activity: Pharmaceutical, Pharmacokinetic, and Pharmacodynamic

Pharmaceutical Phase

  • Involves solid dosage form
  • Drug goes through dissolution and disintegration processes

Pharmacokinetic Phase

  • Consists of four stages: Absorption, Distribution, Metabolism, and Excretion

Absorption

  • Movement of drug across membranes
  • Types of absorption:
    • Filtration
    • Simple Diffusion
    • Facilitated Diffusion
    • Active Transport
    • Endocytosis
    • Exocytosis
  • Factors affecting absorption:
    • pH
    • Routes of Administration
    • Dosage form
    • Blood flow
    • Surface area
    • Solubility
    • Drug Concentration
    • Presence of Food in the Stomach

Distribution

  • Transportation of drug in body fluids to various tissues
  • Factors affecting distribution:
    • Blood flow
    • Binding to Plasma Protein
    • Tissue Binding
    • Lipid Solubility
  • Distribution barriers:
    • Blood Brain Barrier
    • Placenta
    • Lipid Solubility of the Drug

Metabolism

  • Process that chemically inactivates a drug
  • Converts drug to a more water-soluble compound for excretion

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Test your knowledge of the physiological and other processes governing drug action. Explore topics such as pharmaceutical processes, pharmacokinetics, and pharmacodynamics.

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