Principles of Disease PATH*3610 Quiz
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Questions and Answers

What is the primary force that drives fluid back into the blood vascular system from the interstitial space?

  • Reduced intravascular oncotic pressure
  • Lymphatic obstruction
  • Increased endothelial permeability
  • Increased vascular hydrostatic pressure (correct)
  • What is the name given to the excessive amount of fluid in a body cavity?

  • Hydrostatic pressure
  • Oncotic pressure
  • Lymphatic obstruction
  • Effusion (correct)
  • Which of the following conditions can contribute to edema by increasing venous hydrostatic pressure?

  • Lymphatic obstruction
  • Inflammation
  • Postural edema (correct)
  • Hypoproteinemia
  • How does hypoproteinemia contribute to edema?

    <p>It reduces intravascular oncotic pressure. (B)</p> Signup and view all the answers

    Which of the following mechanisms contributes to edema by increasing endothelial permeability?

    <p>Inflammation (D)</p> Signup and view all the answers

    Which of the following is NOT a step in the diagnostic process outlined in the content?

    <p>Final Treatment (C)</p> Signup and view all the answers

    What is the name of the non-transcribed sequences at the end of chromosomes that shorten with division?

    <p>Telomeres (A)</p> Signup and view all the answers

    Which of the following cells are considered 'immortal' due to their ability to repair shortened telomeres?

    <p>Germ cells (D)</p> Signup and view all the answers

    What is the name of the phase in the cell cycle where the cell is at rest and not actively dividing?

    <p>G0 (A)</p> Signup and view all the answers

    Which of these factors can influence cell size and tissue size?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the process by which the cell replicates its DNA?

    <p>S phase (C)</p> Signup and view all the answers

    Which of the following is NOT an example of a terminally differentiated cell?

    <p>Epithelial cell (A)</p> Signup and view all the answers

    How do clock genes potentially contribute to aging?

    <p>They control the rate of cell division. (D)</p> Signup and view all the answers

    Which of the following is NOT considered an extrinsic factor that can influence the size of an organ or tissue?

    <p>Genetics (A)</p> Signup and view all the answers

    Which form of necrosis is characterized by the tissue becoming liquid due to enzymatic dissolution?

    <p>Liquefactive Necrosis (A)</p> Signup and view all the answers

    What is the term used to describe the process where cells die due to a breakdown of their ability to maintain water and ions?

    <p>Oncotic Cell Death (B)</p> Signup and view all the answers

    What is the primary cause of cell swelling in oncotic cell death?

    <p>Reduced ATP production (B)</p> Signup and view all the answers

    Which type of necrosis is associated with the formation of autophagosomes?

    <p>Autophagic Necrosis (A)</p> Signup and view all the answers

    What is the primary mechanism by which frostbite leads to tissue necrosis?

    <p>Reduced blood flow to the affected area due to vasoconstriction (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of coagulative necrosis?

    <p>Tissue becomes liquefied (B)</p> Signup and view all the answers

    What is the primary difference between coagulative and liquefactive necrosis?

    <p>The role of enzymes in the process (C)</p> Signup and view all the answers

    Based on the passage, what is the relationship between cell swelling and oncotic cell death?

    <p>Cell swelling is a precursor to oncotic cell death (A)</p> Signup and view all the answers

    Which of the following is NOT a component of haemostasis?

    <p>Red Blood Cells (D)</p> Signup and view all the answers

    What is the smallest perceivable haemorrhage into tissue called?

    <p>Petechia (A)</p> Signup and view all the answers

    What is the term for a blood clot that forms within the vessels of a living organism?

    <p>Thrombus (D)</p> Signup and view all the answers

    Which of the following is a characteristic of coagulation proteins?

    <p>They are activated at a phospholipid surface. (B)</p> Signup and view all the answers

    What is the role of endothelial cells in haemostasis?

    <p>They are normally anticoagulative. (D)</p> Signup and view all the answers

    What is the term for a group of petechia that resemble blood being wiped with a paintbrush?

    <p>Ecchymosis (D)</p> Signup and view all the answers

    Which of the following is essential for both the intrinsic and extrinsic pathways of the coagulation cascade?

    <p>Calcium (D)</p> Signup and view all the answers

    What is the main difference between a thrombus and a postmortem clot?

    <p>A thrombus forms in a living organism, while a postmortem clot forms after death. (A)</p> Signup and view all the answers

    Which of the following best describes the concept of 'disease' as explained in the content?

    <p>A disruption of the body's normal functioning, leading to observable signs and symptoms. (A)</p> Signup and view all the answers

    What is the difference between 'signs' and 'symptoms' of disease?

    <p>Signs are observable changes, while symptoms are the patient's subjective experiences. (D)</p> Signup and view all the answers

    What does the term 'asymptomatic infection' refer to?

    <p>An infection that does not cause any noticeable symptoms. (D)</p> Signup and view all the answers

    Which of these options correctly defines 'case fatality rate (CFR)'?

    <p>The proportion of people with a disease who die from it. (B)</p> Signup and view all the answers

    What is the primary focus of this particular course, as outlined in the content?

    <p>Investigating the failure of the body's adaptive mechanisms in response to disease. (A)</p> Signup and view all the answers

    What is the main purpose of the content provided?

    <p>To help students understand basic concepts related to disease. (B)</p> Signup and view all the answers

    What is the term 'association' used to describe?

    <p>A statistical correlation between two variables. (A)</p> Signup and view all the answers

    What is the difference between 'actual risk' and 'perceived risk'?

    <p>Actual risk is a measure of likelihood, while perceived risk is a subjective feeling of danger. (D)</p> Signup and view all the answers

    Flashcards

    Capillary Blood Pressure

    The pressure exerted by blood within the capillaries, crucial for fluid exchange.

    Edema

    An excessive accumulation of fluid in tissue or body cavities.

    Oncotic Pressure

    The pressure exerted by proteins in blood plasma that attracts water into the vascular system.

    Venous Hydrostatic Pressure

    Pressure within veins that can lead to fluid leakage if too high, commonly in heart failure.

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    Lymphatic System

    A specialized vascular system that removes excess fluid from extracellular space.

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    Telomeres

    Nontranscribed sequences at chromosome ends that shorten during replication.

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    Proliferation

    The process of cell growth and division leading to increased cell numbers.

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    Apoptosis

    Programmed cell death that balances cell numbers with loss.

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    Cell Cycle Stages

    Four key phases of a cell's life: G1, S, G2, and M.

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    G0 Phase

    A resting state where cells do not actively divide.

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    Permanent Cells

    Cells that do not divide, such as neurons and cardiac muscle cells.

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    Stem Cells

    Undifferentiated cells capable of dividing and becoming different cell types.

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    Clock Genes

    Genes that regulate aging and potentially control cell cycles.

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    Coagulative necrosis

    Morphological description of cell death where cells remain the same size and look similar to live cells.

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    Liquefactive necrosis

    Tissue becomes liquid through enzymatic dissolution, often seen in brain injuries.

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    Caseous necrosis

    Tissue partially liquefies and then dehydrates, resembling cheese.

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    Oncotic cell death

    Cell death characterized by swelling of cells beyond normal size until rupture occurs.

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    Hydropic degeneration

    Acute cell swelling that can lead to irreversible damage if not stopped.

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    Autophagy

    The process where damaged organelles are enclosed in membranes to form autophagosomes for degradation.

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    Ischemia

    Reduced blood flow leading to tissue damage and cell death, especially in frostbite.

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    Cell membrane integrity

    Maintaining the structure of cell membranes is crucial for preventing cell death.

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    Asymptomatic Infections

    Infections where individuals do not show symptoms.

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    Petechia

    Small, pinpoint hemorrhages in tissue due to platelet deficiency.

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    Cause of Disease

    The initial factor that leads to the development of a disease.

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    Ecchymosis

    A larger bruise formed by a group of petechia, resembling paintbrush strokes.

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    Infection Fatality Rate (IFR)

    The percentage of infected individuals who die from the disease.

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    Mechanisms of Disease

    The processes that illustrate how the cause leads to disease development.

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    Case Fatality Rate (CFR)

    The percentage of those showing symptoms who die from the disease.

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    Haemostasis

    The process of stopping hemorrhage and blood clotting.

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    Clinical Signs

    Observable effects or lesions in a patient indicating disease presence.

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    Coagulation cascade

    A series of protein interactions leading to blood clot formation.

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    Homeostasis

    The body's ability to maintain stable internal conditions.

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    Clinical Signs vs Symptoms

    Signs are observable; symptoms are felt by patients.

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    Thrombus

    A blood clot that forms within blood vessels in a living organism.

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    Diagnostic Process

    The methodical approach to identifying diseases based on clinical signs.

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    Differential Diagnosis

    A list of possible conditions that could cause the observed signs.

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    Risk of Disease

    The chance of acquiring a disease or dying from it.

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    Postmortem clot

    A clot that forms in blood vessels after death.

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    Homeostasis

    A balanced state where cells meet physiological demands.

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    Association in Disease

    A term denoting a link between events or conditions.

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    Intrinsic pathway

    Part of the coagulation cascade initiated by blood vessel injury.

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    Adaptive Mechanisms

    The body's responses to maintain homeostasis during stress.

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    Extrinsic pathway

    The coagulation pathway that is activated by tissue factor from outside the vessel.

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    Cellular Injury

    Damage to cells that disrupts normal function.

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    Confirmational Bias

    The tendency to search for, interpret, or remember information that confirms one's preconceptions.

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    Study Notes

    Course Instructor-in-Charge

    • Dr. Robert A. Foster
    • BVSc. (Qld), PhD. (JCUNQ), MANZCVS, Diplomate ACVP, Professor

    Course Title and Code

    • Principles of Disease
    • PATH*3610

    Course Year

    • 2025

    Course Description

    • Designed for students with interests in nutrition and biology.
    • Covers basic disease concepts in cells, tissues, organs, and body fluids.
    • Focuses on disease processes from physical, toxic, microbiological, and other causes.

    Course Objectives

    • Integrate anatomy, physiology, and disease mechanisms.
    • Explain disease effects on the body and rationale for treatment.
    • Objectively and scientifically interpret medical articles.
    • Understand the significance of common pathological processes.
    • Emphasize the induction of disease and the body's response.
    • Define medical terms related to general pathology.
    • Outline general mechanisms of cell and tissue injury/death.
    • Describe the general response and outcome of injury to tissues.
    • Explain the mechanisms of infectious diseases and microbial effects on the body.
    • Outline methods for preventing infectious diseases.
    • Detail the development, effects, and treatments of neoplasia.
    • Describe responses to injury in various organs (skin, stomach, intestines, bone marrow, blood, lungs, liver, kidneys, heart, vessels, brain, spinal cord, bones, and joints).
    • Explain clinical signs and reasons behind them when organs fail.
    • Describe and provide examples of treatments for diseases.

    General Considerations

    • Course is about disease ('dis-' from, 'ease'- formation of disease).
    • Course integrates anatomy, physiology, and disease mechanisms to understand common diseases and therapies.
    • Course focuses on failure of the body's homeostatic mechanisms.
    • Signs are observable symptoms of diseases.
    • Symptoms are subjective experiences of disease.
    • Challenges include the large volume of medical terminology
    • Define key terms like Incidence, Prevalence, Asymptomatic infections, Infection fatality rate, Case fatality rate (IFR and CFR), and Association.
    • Articulates Koch postulates as the basis for determining disease causation.

    Cellular Injury, Death, and Adaptation

    • Homeostasis is cell's ability to cope with physiological demands.
    • Injury occurs when demands exceed the cell's adaptation ability.
    • Three responses: adaptation, reversible injury, and irreversible injury and cell death.
    • Potential causes of cell injury include oxygen deprivation, physical agents, chemical agents, infectious agents, immunological reactions, genetic derangements, nutritional imbalances, and aging.
    • Defects in membrane permeability, mitochondrial damage, reactive oxygen/nitrogen species (ROS/RNS) formation are common injury pathways.
    • Discuss cell death mechanisms (apoptosis, necrosis).
    • Describe different methods of cell death on a microscopic level (coagulative, liquefactive, caseous, gangrenous necrosis.
    • Metaplasia is one cell type changing to another.

    Problem Solving and Diagnosis

    • Processes of pathogenesis involve three steps: cause, mechanisms, and clinical outcomes.

    Circulatory Disturbances

    • Vascular systems transport cells, nutrients, and wastes, maintaining fluid and electrolyte balance.
    • Starling forces and regulation of capillary/interstitial fluid balance are explained.
    • Edema, as a specific circulatory disturbance, is caused by differences in hydrostatic pressure and oncotic pressure.
    • Haemorrhage is the loss of blood from a vessel or blood clot (from blood flow disruption into interstitial fluid).
    • Thrombosis is the formation of blood clot within blood vessels.

    Immunology

    • Immune systems maintain health by preventing foreign material entry and removing altered/damaged cells.
    • Immunology distinguishes between antigens and immunogens
    • Innate and adaptive immunity mechanisms are elaborated.
    • Discussion of specific cells, cytokines, and the role of antibodies.
    • Discusses non-specific and specific immune responses; cell-mediated; and antibody-mediated immunity.

    Inflammation, Healing, and Repair

    • Injury initiating and inflammation process (acute and chronic).
    • Repair processes (regeneration and fibrosis).
    • Explain possible underlying mechanisms of these processes.
    • Discuss the cardinal signs of inflammation: redness, swelling, heat, pain, and loss of function.

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    Description

    Test your knowledge on the core concepts of disease as taught in the Principles of Disease course. This quiz covers topics related to disease mechanisms, the body's response to injury, and the integration of anatomy and physiology with pathology. It's essential for students focusing on nutrition and biology.

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