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Questions and Answers
What is the primary force that drives fluid back into the blood vascular system from the interstitial space?
What is the primary force that drives fluid back into the blood vascular system from the interstitial space?
What is the name given to the excessive amount of fluid in a body cavity?
What is the name given to the excessive amount of fluid in a body cavity?
Which of the following conditions can contribute to edema by increasing venous hydrostatic pressure?
Which of the following conditions can contribute to edema by increasing venous hydrostatic pressure?
How does hypoproteinemia contribute to edema?
How does hypoproteinemia contribute to edema?
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Which of the following mechanisms contributes to edema by increasing endothelial permeability?
Which of the following mechanisms contributes to edema by increasing endothelial permeability?
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Which of the following is NOT a step in the diagnostic process outlined in the content?
Which of the following is NOT a step in the diagnostic process outlined in the content?
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What is the name of the non-transcribed sequences at the end of chromosomes that shorten with division?
What is the name of the non-transcribed sequences at the end of chromosomes that shorten with division?
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Which of the following cells are considered 'immortal' due to their ability to repair shortened telomeres?
Which of the following cells are considered 'immortal' due to their ability to repair shortened telomeres?
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What is the name of the phase in the cell cycle where the cell is at rest and not actively dividing?
What is the name of the phase in the cell cycle where the cell is at rest and not actively dividing?
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Which of these factors can influence cell size and tissue size?
Which of these factors can influence cell size and tissue size?
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What is the process by which the cell replicates its DNA?
What is the process by which the cell replicates its DNA?
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Which of the following is NOT an example of a terminally differentiated cell?
Which of the following is NOT an example of a terminally differentiated cell?
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How do clock genes potentially contribute to aging?
How do clock genes potentially contribute to aging?
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Which of the following is NOT considered an extrinsic factor that can influence the size of an organ or tissue?
Which of the following is NOT considered an extrinsic factor that can influence the size of an organ or tissue?
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Which form of necrosis is characterized by the tissue becoming liquid due to enzymatic dissolution?
Which form of necrosis is characterized by the tissue becoming liquid due to enzymatic dissolution?
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What is the term used to describe the process where cells die due to a breakdown of their ability to maintain water and ions?
What is the term used to describe the process where cells die due to a breakdown of their ability to maintain water and ions?
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What is the primary cause of cell swelling in oncotic cell death?
What is the primary cause of cell swelling in oncotic cell death?
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Which type of necrosis is associated with the formation of autophagosomes?
Which type of necrosis is associated with the formation of autophagosomes?
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What is the primary mechanism by which frostbite leads to tissue necrosis?
What is the primary mechanism by which frostbite leads to tissue necrosis?
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Which of the following is NOT a characteristic of coagulative necrosis?
Which of the following is NOT a characteristic of coagulative necrosis?
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What is the primary difference between coagulative and liquefactive necrosis?
What is the primary difference between coagulative and liquefactive necrosis?
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Based on the passage, what is the relationship between cell swelling and oncotic cell death?
Based on the passage, what is the relationship between cell swelling and oncotic cell death?
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Which of the following is NOT a component of haemostasis?
Which of the following is NOT a component of haemostasis?
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What is the smallest perceivable haemorrhage into tissue called?
What is the smallest perceivable haemorrhage into tissue called?
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What is the term for a blood clot that forms within the vessels of a living organism?
What is the term for a blood clot that forms within the vessels of a living organism?
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Which of the following is a characteristic of coagulation proteins?
Which of the following is a characteristic of coagulation proteins?
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What is the role of endothelial cells in haemostasis?
What is the role of endothelial cells in haemostasis?
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What is the term for a group of petechia that resemble blood being wiped with a paintbrush?
What is the term for a group of petechia that resemble blood being wiped with a paintbrush?
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Which of the following is essential for both the intrinsic and extrinsic pathways of the coagulation cascade?
Which of the following is essential for both the intrinsic and extrinsic pathways of the coagulation cascade?
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What is the main difference between a thrombus and a postmortem clot?
What is the main difference between a thrombus and a postmortem clot?
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Which of the following best describes the concept of 'disease' as explained in the content?
Which of the following best describes the concept of 'disease' as explained in the content?
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What is the difference between 'signs' and 'symptoms' of disease?
What is the difference between 'signs' and 'symptoms' of disease?
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What does the term 'asymptomatic infection' refer to?
What does the term 'asymptomatic infection' refer to?
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Which of these options correctly defines 'case fatality rate (CFR)'?
Which of these options correctly defines 'case fatality rate (CFR)'?
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What is the primary focus of this particular course, as outlined in the content?
What is the primary focus of this particular course, as outlined in the content?
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What is the main purpose of the content provided?
What is the main purpose of the content provided?
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What is the term 'association' used to describe?
What is the term 'association' used to describe?
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What is the difference between 'actual risk' and 'perceived risk'?
What is the difference between 'actual risk' and 'perceived risk'?
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Flashcards
Capillary Blood Pressure
Capillary Blood Pressure
The pressure exerted by blood within the capillaries, crucial for fluid exchange.
Edema
Edema
An excessive accumulation of fluid in tissue or body cavities.
Oncotic Pressure
Oncotic Pressure
The pressure exerted by proteins in blood plasma that attracts water into the vascular system.
Venous Hydrostatic Pressure
Venous Hydrostatic Pressure
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Lymphatic System
Lymphatic System
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Telomeres
Telomeres
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Proliferation
Proliferation
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Apoptosis
Apoptosis
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Cell Cycle Stages
Cell Cycle Stages
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G0 Phase
G0 Phase
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Permanent Cells
Permanent Cells
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Stem Cells
Stem Cells
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Clock Genes
Clock Genes
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Coagulative necrosis
Coagulative necrosis
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Liquefactive necrosis
Liquefactive necrosis
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Caseous necrosis
Caseous necrosis
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Oncotic cell death
Oncotic cell death
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Hydropic degeneration
Hydropic degeneration
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Autophagy
Autophagy
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Ischemia
Ischemia
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Cell membrane integrity
Cell membrane integrity
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Asymptomatic Infections
Asymptomatic Infections
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Petechia
Petechia
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Cause of Disease
Cause of Disease
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Ecchymosis
Ecchymosis
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Infection Fatality Rate (IFR)
Infection Fatality Rate (IFR)
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Mechanisms of Disease
Mechanisms of Disease
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Case Fatality Rate (CFR)
Case Fatality Rate (CFR)
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Haemostasis
Haemostasis
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Clinical Signs
Clinical Signs
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Coagulation cascade
Coagulation cascade
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Homeostasis
Homeostasis
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Clinical Signs vs Symptoms
Clinical Signs vs Symptoms
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Thrombus
Thrombus
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Diagnostic Process
Diagnostic Process
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Differential Diagnosis
Differential Diagnosis
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Risk of Disease
Risk of Disease
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Postmortem clot
Postmortem clot
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Homeostasis
Homeostasis
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Association in Disease
Association in Disease
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Intrinsic pathway
Intrinsic pathway
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Adaptive Mechanisms
Adaptive Mechanisms
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Extrinsic pathway
Extrinsic pathway
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Cellular Injury
Cellular Injury
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Confirmational Bias
Confirmational Bias
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Study Notes
Course Instructor-in-Charge
- Dr. Robert A. Foster
- BVSc. (Qld), PhD. (JCUNQ), MANZCVS, Diplomate ACVP, Professor
Course Title and Code
- Principles of Disease
- PATH*3610
Course Year
- 2025
Course Description
- Designed for students with interests in nutrition and biology.
- Covers basic disease concepts in cells, tissues, organs, and body fluids.
- Focuses on disease processes from physical, toxic, microbiological, and other causes.
Course Objectives
- Integrate anatomy, physiology, and disease mechanisms.
- Explain disease effects on the body and rationale for treatment.
- Objectively and scientifically interpret medical articles.
- Understand the significance of common pathological processes.
- Emphasize the induction of disease and the body's response.
- Define medical terms related to general pathology.
- Outline general mechanisms of cell and tissue injury/death.
- Describe the general response and outcome of injury to tissues.
- Explain the mechanisms of infectious diseases and microbial effects on the body.
- Outline methods for preventing infectious diseases.
- Detail the development, effects, and treatments of neoplasia.
- Describe responses to injury in various organs (skin, stomach, intestines, bone marrow, blood, lungs, liver, kidneys, heart, vessels, brain, spinal cord, bones, and joints).
- Explain clinical signs and reasons behind them when organs fail.
- Describe and provide examples of treatments for diseases.
General Considerations
- Course is about disease ('dis-' from, 'ease'- formation of disease).
- Course integrates anatomy, physiology, and disease mechanisms to understand common diseases and therapies.
- Course focuses on failure of the body's homeostatic mechanisms.
- Signs are observable symptoms of diseases.
- Symptoms are subjective experiences of disease.
- Challenges include the large volume of medical terminology
- Define key terms like Incidence, Prevalence, Asymptomatic infections, Infection fatality rate, Case fatality rate (IFR and CFR), and Association.
- Articulates Koch postulates as the basis for determining disease causation.
Cellular Injury, Death, and Adaptation
- Homeostasis is cell's ability to cope with physiological demands.
- Injury occurs when demands exceed the cell's adaptation ability.
- Three responses: adaptation, reversible injury, and irreversible injury and cell death.
- Potential causes of cell injury include oxygen deprivation, physical agents, chemical agents, infectious agents, immunological reactions, genetic derangements, nutritional imbalances, and aging.
- Defects in membrane permeability, mitochondrial damage, reactive oxygen/nitrogen species (ROS/RNS) formation are common injury pathways.
- Discuss cell death mechanisms (apoptosis, necrosis).
- Describe different methods of cell death on a microscopic level (coagulative, liquefactive, caseous, gangrenous necrosis.
- Metaplasia is one cell type changing to another.
Problem Solving and Diagnosis
- Processes of pathogenesis involve three steps: cause, mechanisms, and clinical outcomes.
Circulatory Disturbances
- Vascular systems transport cells, nutrients, and wastes, maintaining fluid and electrolyte balance.
- Starling forces and regulation of capillary/interstitial fluid balance are explained.
- Edema, as a specific circulatory disturbance, is caused by differences in hydrostatic pressure and oncotic pressure.
- Haemorrhage is the loss of blood from a vessel or blood clot (from blood flow disruption into interstitial fluid).
- Thrombosis is the formation of blood clot within blood vessels.
Immunology
- Immune systems maintain health by preventing foreign material entry and removing altered/damaged cells.
- Immunology distinguishes between antigens and immunogens
- Innate and adaptive immunity mechanisms are elaborated.
- Discussion of specific cells, cytokines, and the role of antibodies.
- Discusses non-specific and specific immune responses; cell-mediated; and antibody-mediated immunity.
Inflammation, Healing, and Repair
- Injury initiating and inflammation process (acute and chronic).
- Repair processes (regeneration and fibrosis).
- Explain possible underlying mechanisms of these processes.
- Discuss the cardinal signs of inflammation: redness, swelling, heat, pain, and loss of function.
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Description
Test your knowledge on the core concepts of disease as taught in the Principles of Disease course. This quiz covers topics related to disease mechanisms, the body's response to injury, and the integration of anatomy and physiology with pathology. It's essential for students focusing on nutrition and biology.