Lecture 7: B cells
20 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

Which type of cells mostly produce IgM (with some IgD) in the primary response?

  • Memory B cells
  • Germinal center B cells
  • Plasma cells (correct)
  • Naive B cells

    • What is the main isotype expressed by most memory B cells according to the text?

  • IgA
  • IgG (correct)
  • IgE
  • IgM

    • What happens to the affinity of antibodies with repeated immunization?

  • Decreases
  • Increases (correct)
  • Fluctuates
  • Stays the same

    • Which type of B cells will outcompete the primary response due to their increased affinity?

    <p>Memory B cells</p> Signup and view all the answers

    What happens as the immune response progresses from secondary to tertiary responses?

    <p>Tertiary response outcompetes primary response</p> Signup and view all the answers

    What is a distinguishing feature of central memory T cells?

    <p>Rapid reactivation by second antigen exposure</p> Signup and view all the answers

    What is a functionally unique characteristic of memory T cells compared to naive T cells?

    <p>Express different surface adhesion molecules</p> Signup and view all the answers

    Which cytokine can lead to increased expression of Bcl-2 in memory T cells?

    <p>Interleukin-7 (IL-7)</p> Signup and view all the answers

    Which type of memory T cells contribute better to first-line defenses?

    <p>Effector memory T cells</p> Signup and view all the answers

    What is the outcome of the experiment regarding CD8+ Memory T cells in MHCII deficient mice?

    <p>Reduced maintenance compared to WT mice</p> Signup and view all the answers

    What role does CD4+ T cell activation with MHCII play in CD8+ T cell longevity?

    <p>Increases longevity of CD8+ T cells</p> Signup and view all the answers

    What is the primary difference between active and passive immunization?

    <p>Memory response is generated in active immunization, but not in passive immunization</p> Signup and view all the answers

    What is the purpose of adjuvants in vaccines?

    <p>To promote inflammation and enhance the immune response to the vaccine</p> Signup and view all the answers

    Why do early childhood vaccinations typically start at 6 months of age?

    <p>To allow acquired antibodies through passive transfer to die off before new ones are introduced</p> Signup and view all the answers

    What can happen with both passive and active immunization due to original antigenic sin?

    <p>Production of ineffective antibodies and weak immunity</p> Signup and view all the answers

    Why do attenuated vaccines have built-in adjuvants?

    <p>To trigger an immune response through pathogen-associated molecular patterns (PAMPs)</p> Signup and view all the answers

    What is the purpose of promoting some inflammation in weak antigen-stimulating situations?

    <p>To recruit more immune cells and enhance effectiveness</p> Signup and view all the answers

    Why is a passive immunization considered temporary?

    <p>It does not generate a memory response</p> Signup and view all the answers

    How do vaccines induce active immunity?

    <p>By exposing individuals to non-dangerous forms of infectious agents purposefully</p> Signup and view all the answers

    How does herd immunity reduce the pathogen reservoir?

    <p>By significantly reducing the number of susceptible individuals</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser