Primary Defences Against Diseases
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Questions and Answers

What is the name of the outer layer of skin?

Epidermis

The epidermis is made up of living cells.

False (B)

What substance is produced by the sebaceous glands?

Sebum

Which of the following is NOT a primary defence against pathogens?

<p>Specific immune response (A)</p> Signup and view all the answers

What is the name of the process that involves platelets and clotting factors?

<p>Blood clotting</p> Signup and view all the answers

Blood clotting is a specific immune response.

<p>False (B)</p> Signup and view all the answers

What does the term 'enzyme cascade' refer to?

<p>A sequence of biochemical reactions</p> Signup and view all the answers

What is the name of the protein that forms a mesh during blood clotting, trapping platelets and red blood cells?

<p>Fibrin</p> Signup and view all the answers

Serotonin is released by platelets to help blood vessels contract.

<p>True (A)</p> Signup and view all the answers

What is the name of the dead cells that form a scab after a wound heals?

<p>Blood clot</p> Signup and view all the answers

What is a natural biological response to foreign stimuli or tissue damage?

<p>Inflammation</p> Signup and view all the answers

Which of the following is NOT a sign of inflammation?

<p>Numbness (D)</p> Signup and view all the answers

What type of cells release histamine during inflammation?

<p>Mast cells</p> Signup and view all the answers

Which of the following is NOT a characteristic of expulsive reflexes?

<p>Specific to a particular pathogen (D)</p> Signup and view all the answers

Coughing helps to clear the airway and prevent pathogens from entering the lungs.

<p>True (A)</p> Signup and view all the answers

What is the name of the reflex that is primarily used to clear the nasal passages and upper respiratory tract?

<p>Sneezing</p> Signup and view all the answers

Mucus membranes form a physical barrier against pathogens.

<p>False (B)</p> Signup and view all the answers

What type of cells secrete mucus to trap pathogens?

<p>Goblet cells</p> Signup and view all the answers

Cilia are hair-like structures that help to move mucus along the airways.

<p>True (A)</p> Signup and view all the answers

What is the name of the passage that connects the middle ear to the back of the throat?

<p>Eustachian tube</p> Signup and view all the answers

The female reproductive system is considered to be a sterile environment.

<p>False (B)</p> Signup and view all the answers

Flashcards

Epidermis

The outermost layer of skin, composed of dead, hardened cells filled with keratin. Acts as a physical barrier against pathogens.

Keratin

A fibrous protein that makes up the majority of the epidermis, providing strength and protection.

Keratinization

The process by which cells in the base of the epidermis divide, migrate outwards, and produce keratin, eventually becoming dead, hardened cells.

Sebum

Oily substance secreted by sebaceous glands on the skin surface, contains fatty acids that create an acidic layer, inhibiting the growth of harmful bacteria.

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Blood clotting

The process of forming a blood clot to prevent infection and blood loss after injury.

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Platelets

Cells in the blood that release clotting factors and are involved in blood clot formation.

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Clotting factors

Substances released by platelets that trigger a chain reaction of enzymatic activity leading to clot formation.

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Enzyme cascade

A sequence of biochemical reactions where one enzyme activates another, leading to a rapid cascade of events, like in blood clotting.

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Thrombin

An active enzyme formed from prothrombin that converts fibrinogen into fibrin, creating a mesh-like structure for the blood clot.

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Fibrinogen

A soluble protein in blood that is converted into fibrin by thrombin, forming the meshwork of the blood clot.

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Fibrin

An insoluble protein formed from fibrinogen by thrombin, creating a mesh-like network that traps platelets and red blood cells, forming a blood clot.

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Scab

A dried-up blood clot that protects a wound from infection, allowing the underlying skin to heal.

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Stem cells

Specialized cells in the epidermis that can divide and differentiate into different skin cells, enabling healing.

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Inflammation

A natural bodily response to tissue damage or foreign stimuli, characterized by swelling, redness, heat, and pain.

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Mast cells

Specialized cells in tissues that release histamine in response to infection or injury.

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Histamine

A chemical released by mast cells that causes blood vessels to dilate (vasodilation) and increases their permeability to white blood cells.

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Vasodilation

The widening of blood vessels, causing increased blood flow to an area, often associated with inflammation.

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Increased capillary permeability

The process of fluids, white blood cells, and proteins leaving the blood vessels and entering the tissue fluid, contributing to swelling (oedema).

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Tissue fluid

Excess tissue fluid that drains into the lymphatic system, which contains lymphocytes.

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Lymphocytes

A type of white blood cell responsible for specific immune responses against pathogens.

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Expulsive reflexes

Automatic bodily reflexes that expel harmful substances from the body, such as coughing and sneezing.

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Coughing

A forceful expulsion of air from the lungs, triggered by irritants in the airways, to clear the respiratory tract.

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Sneezing

A forceful expulsion of air through the nose and mouth, triggered by irritants in the nasal passages, to clear the upper respiratory tract.

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Mucous membrane

A specialized lining found in the body's airways, lungs, and digestive system, containing mucus-secreting cells and ciliated cells.

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Goblet cells

Cells in mucous membranes that secrete mucus, which traps pathogens.

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Mucus

A viscous fluid secreted by goblet cells in mucous membranes, which traps pathogens.

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Cilia

Specialized hair-like structures found in the mucous membranes of the airways, that move in a coordinated fashion to waft mucus, and trapped pathogens, upwards towards the throat.

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Trachea (windpipe)

The lining of the throat, where the trachea opens up into the oesophagus, where mucus is transported by cilia.

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Oesophagus

The tube that connects the mouth to the stomach, where mucus is swallowed and then passes through the digestive system.

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Stomach acid

The acidic fluid in the stomach with a pH of 1-2, that helps to breakdown food and kill or inhibit the growth of many pathogens.

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Tear fluid

The transparent fluid that lubricates and protects the eyes, containing antibodies and enzymes that help to fight pathogens.

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Ear wax

Waxy substance in the ear canal that traps pathogens and keeps dust and debris out of the ear.

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Cervix

The opening of the uterus into the vagina, where a mucus plug forms to help prevent pathogens from entering the female reproductive system.

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Study Notes

Primary Defences Against Diseases

  • Pathogenic organisms must enter the host body to cause harm
  • Animals have evolved primary defences to prevent pathogenic organism entry
  • These defences are non-specific, preventing any pathogen entry

The Skin

  • The epidermis, the outer skin layer, is composed of dead, hardened cells filled with keratin
  • Keratin acts as a physical barrier against pathogens
  • Keratinisation is the process where cells at the epidermis base multiply, migrate outwards, dry out and die, forming a keratinised layer of dead skin cells
  • Sebum, an oily substance produced by sebaceous glands, creates an acidic layer on the skin's surface
  • This acidic layer prevents the growth of harmful bacteria
  • Harmless microorganisms on the skin's surface also reduce pathogen growth

Blood Clotting & Skin Repair

  • Blood clots form when skin is wounded to prevent infection and excessive blood loss
  • Platelets release clotting factors
  • Clotting factors activate an enzyme cascade, a chain reaction of enzymes activating each other
  • Thromboplastin and calcium ions convert prothrombin into thrombin
  • Thrombin catalyses the conversion of fibrinogen into fibrin, forming a mesh to trap platelets and red blood cells, forming a blood clot
  • Platelets also release serotonin, causing blood vessel smooth muscle to contract, reducing blood flow to the damaged area and drawing the cut edges together
  • The blood clot dries to form a scab, preventing pathogen entry
  • Stem cells within the epidermis form new skin cells, replacing damaged ones beneath the scab
  • The scab eventually detaches when new cells are complete

Inflammation

  • Inflammation is a natural biological response to tissue damage or foreign stimuli
  • Indicators include swelling, redness, heat, and pain
  • Mast cells detect microorganisms in tissue
  • Capillary walls become more permeable to white blood cells and proteins
  • White blood cells and plasma exit blood vessels into tissue, causing swelling
  • Excess tissue fluid drains into the lymphatic system
  • Lymphocytes in the lymphatic system come in contact with pathogens, triggering a specific immune response

Expulsive Reflexes (Coughing and Sneezing)

  • Expulsive reflexes expel harmful substances like pathogens from the body
  • Coughing expels air from the lungs to clear airways, combating infections like bronchitis
  • Sneezing expels irritants/pathogens from the nasal passages and upper respiratory tract

Mucous Membranes

  • Mucous membranes are exchange surfaces where substances like oxygen and nutrients enter the blood
  • Thin membranes are less protected from pathogens
  • The respiratory system, digestive system, eyes, and ears are exposed to air and food which may contain microorganisms
  • Mucous membranes line these areas to protect them
  • Goblet cells secrete mucus, trapping pathogens
  • Ciliated cells move the mucus, removing pathogens and carrying them to the oesophagus
  • Pathogens often destroyed by stomach acidity

Other Primary Defences

  • Body fluids like tears and saliva contain antibodies and digestive enzymes which help protect against pathogens in eyes and digestive systems
  • Ear canals are lined with wax which traps pathogens
  • The female reproductive system has a mucus plug in the cervix to maintain acidic conditions, preventing pathogen entry

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Description

This quiz explores the body's primary defenses against diseases, focusing on the skin's structure and function. Learn how the skin acts as a barrier to pathogens and the role of blood clotting in protecting the body. Test your knowledge about these crucial biological defenses.

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