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Primary Amyloidosis and Plasma Cell Disorders Quiz
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Primary Amyloidosis and Plasma Cell Disorders Quiz

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Questions and Answers

What determines the amyloidogenic potential of a particular light chain?

  • The type of plasma cell producing the light chain
  • The specific amino acid sequence of the light chain (correct)
  • The presence of multiple myeloma
  • The amount of light chain produced

    • What is the primary manifestation in patients with primary amyloidosis?

  • Increased plasma cell count in the bone marrow
  • Classic multiple myeloma
  • Production of an abnormal protein (correct)
  • Production of tumor masses

    • What can be found in the serum or urine of most patients with primary amyloidosis?

  • Abnormal plasma cells
  • Tumor masses
  • Monoclonal immunoglobulins or free light chains (correct)
  • Classic multiple myeloma

    • What is the underlying condition in patients with primary amyloidosis?

    <p>Monoclonal gammopathy</p> Signup and view all the answers

    What is the distinguishing feature of primary amyloidosis compared to classic multiple myeloma?

    <p>The absence of overt B-cell neoplasm</p> Signup and view all the answers

    What is the most common form of amyloidosis in the United States?

    <p>AL type</p> Signup and view all the answers

    What percentage of individuals with multiple myeloma may experience systemic amyloidosis?

    <p>5-15%</p> Signup and view all the answers

    What is the term used to refer to the abnormal amounts of a single Ig produced by malignant plasma cells in multiple myeloma?

    <p>M spike</p> Signup and view all the answers

    In addition to whole Ig molecules, what do malignant plasma cells in multiple myeloma often secrete?

    <p>Bence-Jones proteins</p> Signup and view all the answers

    What happens to the free light chains produced by malignant plasma cells in primary amyloidosis?

    <p>They are deposited in tissues as amyloid</p> Signup and view all the answers

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