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Primary Amyloidosis and Plasma Cell Disorders Quiz

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Primary Amyloidosis and Plasma Cell Disorders Quiz

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Questions and Answers

What determines the amyloidogenic potential of a particular light chain?

The type of plasma cell producing the light chain

The specific amino acid sequence of the light chain (correct)

The presence of multiple myeloma

The amount of light chain produced

What is the primary manifestation in patients with primary amyloidosis?

Increased plasma cell count in the bone marrow

Classic multiple myeloma

Production of an abnormal protein (correct)

Production of tumor masses

What can be found in the serum or urine of most patients with primary amyloidosis?

Abnormal plasma cells

Tumor masses

Monoclonal immunoglobulins or free light chains (correct)

Classic multiple myeloma

What is the underlying condition in patients with primary amyloidosis?

Monoclonal gammopathy (D) Signup and view all the answers

What is the distinguishing feature of primary amyloidosis compared to classic multiple myeloma?

The absence of overt B-cell neoplasm (B) Signup and view all the answers

What is the most common form of amyloidosis in the United States?

AL type (C) Signup and view all the answers

What percentage of individuals with multiple myeloma may experience systemic amyloidosis?

5-15% (D) Signup and view all the answers

What is the term used to refer to the abnormal amounts of a single Ig produced by malignant plasma cells in multiple myeloma?

M spike (C) Signup and view all the answers

In addition to whole Ig molecules, what do malignant plasma cells in multiple myeloma often secrete?

Bence-Jones proteins (C) Signup and view all the answers

What happens to the free light chains produced by malignant plasma cells in primary amyloidosis?

They are deposited in tissues as amyloid (B) Signup and view all the answers