Podcast
Questions and Answers
What determines the amyloidogenic potential of a particular light chain?
What determines the amyloidogenic potential of a particular light chain?
- The type of plasma cell producing the light chain
- The specific amino acid sequence of the light chain (correct)
- The presence of multiple myeloma
- The amount of light chain produced
What is the primary manifestation in patients with primary amyloidosis?
What is the primary manifestation in patients with primary amyloidosis?
- Increased plasma cell count in the bone marrow
- Classic multiple myeloma
- Production of an abnormal protein (correct)
- Production of tumor masses
What can be found in the serum or urine of most patients with primary amyloidosis?
What can be found in the serum or urine of most patients with primary amyloidosis?
- Abnormal plasma cells
- Tumor masses
- Monoclonal immunoglobulins or free light chains (correct)
- Classic multiple myeloma
What is the underlying condition in patients with primary amyloidosis?
What is the underlying condition in patients with primary amyloidosis?
What is the distinguishing feature of primary amyloidosis compared to classic multiple myeloma?
What is the distinguishing feature of primary amyloidosis compared to classic multiple myeloma?
What is the most common form of amyloidosis in the United States?
What is the most common form of amyloidosis in the United States?
What percentage of individuals with multiple myeloma may experience systemic amyloidosis?
What percentage of individuals with multiple myeloma may experience systemic amyloidosis?
What is the term used to refer to the abnormal amounts of a single Ig produced by malignant plasma cells in multiple myeloma?
What is the term used to refer to the abnormal amounts of a single Ig produced by malignant plasma cells in multiple myeloma?
In addition to whole Ig molecules, what do malignant plasma cells in multiple myeloma often secrete?
In addition to whole Ig molecules, what do malignant plasma cells in multiple myeloma often secrete?
What happens to the free light chains produced by malignant plasma cells in primary amyloidosis?
What happens to the free light chains produced by malignant plasma cells in primary amyloidosis?
