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Questions and Answers
Which term describes the ability of the liver and intestine to metabolize substances before reaching the systemic circulation?
Which term describes the ability of the liver and intestine to metabolize substances before reaching the systemic circulation?
- Systemic availability metabolism
- Intestinal bypass metabolism
- Hepatic circulation metabolism
- Presystemic first-pass metabolism (correct)
What are the major pathways of presystemic intestinal first-pass metabolism in humans?
What are the major pathways of presystemic intestinal first-pass metabolism in humans?
- Hydrolysis and conjugation
- Sulfonation and glucuronidation (correct)
- Methylation and acetylation
- Oxidation and reduction
Which enzyme is primarily responsible for the presystemic metabolism of drugs with low bioavailability?
Which enzyme is primarily responsible for the presystemic metabolism of drugs with low bioavailability?
- CYP2D6
- CYP2C9
- CYP1A2
- CYP3A4 (correct)
How can coadministration of a CYP3A4 inhibitor affect the pharmacokinetics of a drug?
How can coadministration of a CYP3A4 inhibitor affect the pharmacokinetics of a drug?
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What effect do inducers have on drug absorption and oral bioavailability?
What effect do inducers have on drug absorption and oral bioavailability?
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Why do orally administered drugs susceptible to glucuronosyltransferases, sulfotransferases, and glutathione transferases have low oral bioavailability?
Why do orally administered drugs susceptible to glucuronosyltransferases, sulfotransferases, and glutathione transferases have low oral bioavailability?
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