Prenatal Development and Neurulation

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Questions and Answers

List the periods of prenatal development in the correct sequence and indicate their duration.

  • proliferative - two weeks, fetal - then until birth, embryonic - from the end of the second to 8 weeks
  • proliferative - two weeks, embryonic - from the end of the second to 8 weeks, fetal - then until birth (correct)
  • fetal - then until birth, proliferative - two weeks, embryonic - from the end of the second to 8 weeks
  • embryonic - from the end of the second to 8 weeks, proliferative - two weeks, fetal-then until birth

How long does the proliferative period last?

  • Three weeks
  • Two weeks (correct)
  • One week
  • Four weeks

Indicate the duration of the embryonic period:

  • After 8th week
  • 2-8 weeks (correct)
  • First two weeks

Which statement is true?

<p>The cells of the inner cell mass are the progenitors of the embryo (B), The process of gastrulation begins at the end of the second embryonic week (C), The mesoderm is responsible for the formation of bones, muscles, etc. (D), The thickening of the surface of the primitive ectoderm is called primitive plaque (E)</p> Signup and view all the answers

Give a brief description of the gastrulation process.

<p>Gastrulation lasts between the 14th and the 20th day. During this process, the ectoderm and endoderm stratify, and a third layer, the mesoderm, forms between them. The formation of these three embryonic leaves, from which the human body arises, begins in the cranial region and progresses caudally.</p> Signup and view all the answers

Nervous system, sensory system, epidermis, mammary and cutaneous glands, epithelium of oral and nasal cavities, and tooth enamel develop from:

<p>Ectoderm (B)</p> Signup and view all the answers

Bone cartilage, blood, dentin, pulp, cementum, and periodontal ligament develop from:

<p>Mesoderm (B)</p> Signup and view all the answers

Name the parts of the embryonic tube:

<p>Pars cranialis (A), Pars umbilicalis (B), Pars caudalis (C)</p> Signup and view all the answers

Flashcards

Embryonic period

The period of prenatal development lasting from the end of the second week to the eighth week.

Fetal period

The period of prenatal development starting from the ninth week until birth.

What is the origin of the embryo?

The inner cell mass, a cluster of cells within the blastocyst, is the progenitor of the embryo.

Gastrulation

The formation of the three germ layers: ectoderm, endoderm, and mesoderm.

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What does the ectoderm form?

The ectoderm gives rise to the nervous system, skin, and sensory organs.

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What does the endoderm form?

The endoderm gives rise to the lining of the digestive and respiratory systems.

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What does the mesoderm form?

The mesoderm gives rise to muscles, bones, blood, and connective tissue.

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Neurulation

The process of forming the neural tube, which will eventually become the brain and spinal cord.

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How does the neural tube close?

The neural tube closes first in the cervical region, then anteriorly and posteriorly.

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What is the oropharyngeal membrane?

The oropharyngeal membrane is a thin membrane that separates the primitive oral cavity (stomodeum) from the foregut.

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What does the mandibular arch form?

The mandibular arch forms the maxillary and mandibular processes.

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What do the pharyngeal arches form?

The pharyngeal arches are responsible for the formation of structures in the head and neck.

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How do the maxillary processes develop?

The maxillary processes grow forward and upward, forming the upper lateral edge of the mouth.

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How is the palate formed?

The palate is formed by the fusion of the maxillary and frontonasal processes.

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What does the frontonasal process form?

The primary palate is formed by the frontonasal process, and contains the incisors.

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What forms the secondary palate?

The secondary palate is formed by the lateral palatal growths of the maxillary processes.

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What are the parts of the tooth germ?

The tooth germ is composed of three main elements: the enamel organ, the dental papilla, and the dental sacculus.

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What does the enamel organ form?

The enamel organ forms the enamel of the tooth.

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What does the dental papilla form?

The dental papilla forms the dentin and pulp of the tooth.

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What does the dental sacculus form?

The dental sacculus forms the cementum, periodontal ligament, and alveolar bone.

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What is the bud stage of tooth development?

The bud stage is the first stage of tooth development, characterized by a ball of epithelial cells.

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What is the cap stage of tooth development?

The cap stage is the second stage of tooth development, characterized by the enamel organ forming a cap-like structure.

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What is the bell stage of tooth development?

The bell stage is the third stage of tooth development, characterized by the enamel organ forming a bell-shaped structure.

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What is the enamel knot?

The enamel knot is a cluster of cells in the enamel organ that acts as a signaling center for tooth development.

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What is the enamel cord?

The enamel cord is a row of cells in the enamel organ that helps to shape the crown of the tooth.

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What is the enamel niche?

The enamel niche is a hollow space in the enamel organ where ameloblasts begin to deposit enamel.

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What is the presecretory stage of amelogenesis?

The presecretory stage is the first phase of ameloblast differentiation, where ameloblasts prepare to secrete enamel.

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What is the secretory stage of amelogenesis?

The secretory stage is the second phase of amelogenesis, where ameloblasts secrete the enamel matrix.

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What is the maturation stage of amelogenesis?

The maturation stage is the third phase of amelogenesis, where the enamel matrix undergoes further mineralization and maturation.

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What proteins are secreted during amelogenesis?

The ameloblasts secrete the enamel proteins enamelin and amelogenin, which play a role in enamel formation.

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What is the dentino-enamel junction?

The dentino-enamel junction is the boundary between the dentin and enamel, formed by the interaction of ameloblasts and odontoblasts.

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What is Tomes' process?

Tomes' process is a projection at the end of the ameloblast that helps to deposit enamel.

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What is the peritubular dentin?

The peritubular dentin is the layer of dentin surrounding the dentinal tubules.

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What is the intertubular dentin?

The intertubular dentin is the layer of dentin between the dentinal tubules.

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What is the mantle dentin?

The mantle dentin is the initial layer of dentin deposited at the dentino-enamel junction.

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What is the circumpulpal dentin?

The circumpulpal dentin is the main layer of dentin surrounding the pulp.

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What is the predentin?

The predentin is the unmineralized layer of dentin matrix that is deposited by odontoblasts.

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What are odontoblasts?

The odontoblasts are specialized cells that produce dentin.

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What are Korff's fibers?

Korff's fibers are thick collagen fibers produced by subodontoblasts that are found in the mantle dentin.

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What is the dental pulp?

The dental pulp is the soft tissue inside the tooth that contains blood vessels, nerves, and connective tissue.

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What is the odontoblast zone?

The odontoblast zone is the layer of the dental pulp that contains odontoblasts.

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What is the cell-free zone?

The cell-free zone is a layer of the dental pulp that is relatively devoid of cells and is located beneath the odontoblast zone.

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What is the cell-rich zone?

The cell-rich zone is a layer of the dental pulp that is densely packed with cells, including fibroblasts and undifferentiated mesenchymal cells.

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What is the parietal nerve layer?

The parietal nerve layer is a layer of the dental pulp that contains nerve fibers that innervate the odontoblasts.

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What is Hertwig's epithelial root sheath?

Hertwig's epithelial root sheath is a temporary structure that guides the formation of the tooth root.

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What are cementoblasts?

The cementoblasts are specialized cells that produce cementum.

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What is cementum?

The cementum is a layer of mineralized tissue that covers the root of the tooth.

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What are Sharpey's fibers?

Sharpey's fibers are collagen fibers that anchor the periodontal ligament to the cementum and alveolar bone.

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What is the periodontal ligament?

The periodontal ligament is a fibrous connective tissue that surrounds the tooth root and connects it to the alveolar bone.

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What is the alveolar bone?

The alveolar bone is the bone that surrounds the tooth root and provides support.

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Study Notes

Prenatal Development

  • Periods of prenatal development occur in sequence: proliferative (first two weeks), embryonic (weeks 2-8), fetal (until birth)
  • Proliferative period lasts two weeks
  • Embryonic period lasts from the end of the second to the 8th week.

Gastrulation Process

  • Gastrulation, occurring from the 14th to 20th day, involves the stratification of ectoderm and endoderm and an intermediate layer.
  • Mesoderm develops between ectoderm and endoderm.
  • This process starts in the cranial part of the embryo and progresses caudally.

Neurulation

  • Neurulation is a process that occurs around the 20th day.
  • This process involves the differentiation of cells from the ectoderm, which then forms a neural plate.
  • The neural plate invaginates to form the neural groove.
  • Neural folds close, creating the neural tube, which later forms the brain and spinal cord.

Nervous System Development

  • Nervous system, sensory system, epidermis, mammary, and cutaneous glands, epithelium of oral cavities, and tooth enamel develop from the ectoderm.
  • Bone, cartilage, blood, dentin, pulp, cementum, and periodontal ligament develop from the mesoderm.

Embryonic Tube

  • Parts of the embryonic tube include pars cranialis, pars umbilicalis, and pars caudalis.

Neural Tube

  • The neural tube forms after the neural groove deepens.
  • The neural tube forms the spinal cord and the primitive brain.

Other Key Points

  • The statement that the cells of the inner cell mass are the progenitors of the embryo is true.
  • The statement that the future embryo is formed on the outside of the inner cell mass is false.
  • The process of gastrulation begins at the end of the second embryonic week.
  • The thickening of the surface of the primitive ectoderm is called the primitive plate.
  • The mesoderm is responsible for the formation of bones, muscles, and other structures.
  • On the 17th day, the notochord forms.
  • The paraxial mesoderm is responsible for primary induction of the notochord.

Tooth Germ

  • The tooth germ comprises the enamel organ, dental papilla, dental sac.
  • Physiological stages in the tooth development include early root development, late root development, histodifferentiation, morphodifferentiation, mineralization, maturation, and eruption.
  • The order of the physiological stages: initiation, proliferation, histodifferentiation, morphodifferentiation, apposition, maturation, eruption.

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