Podcast
Questions and Answers
How can changing the temperature of a solution affect the crystallization process?
How can changing the temperature of a solution affect the crystallization process?
Changing the temperature of a solution can affect the crystallization process by altering the thermodynamics, causing the sugar molecules to escape from the liquid and precipitate.
What happens to the solution when some of the liquid evaporates, and how does it relate to crystallization?
What happens to the solution when some of the liquid evaporates, and how does it relate to crystallization?
When some of the liquid evaporates, the solution becomes more concentrated, causing the sugar to precipitate or crystallize.
How does adding another liquid to the solution affect the precipitation of the sugar?
How does adding another liquid to the solution affect the precipitation of the sugar?
Adding another liquid can lead to a competition between the two liquids, causing the sugar molecules to precipitate if they are less soluble in the added liquid.
What is the relationship between the concentration of the solute and the temperature, as shown in the phase diagram?
What is the relationship between the concentration of the solute and the temperature, as shown in the phase diagram?
What is the role of solubility principles in controlling the precipitation of the sugar?
What is the role of solubility principles in controlling the precipitation of the sugar?
What is the difference between reversible and irreversible deformation in the context of tableting?
What is the difference between reversible and irreversible deformation in the context of tableting?
What is the significance of particle size in the tableting process?
What is the significance of particle size in the tableting process?
What is the relationship between particle shape and the tableting process?
What is the relationship between particle shape and the tableting process?
What problem can occur during the tableting process due to elastic deformation?
What problem can occur during the tableting process due to elastic deformation?
What is the desired outcome in terms of deformation in the tableting process?
What is the desired outcome in terms of deformation in the tableting process?
What is one method to induce crystallization, and how does temperature affect the process?
What is one method to induce crystallization, and how does temperature affect the process?
How does the rate of crystallization change at different temperatures, and why?
How does the rate of crystallization change at different temperatures, and why?
What is the relationship between solvent evaporation and crystallization, and how does it relate to the ratio of solvent to solute?
What is the relationship between solvent evaporation and crystallization, and how does it relate to the ratio of solvent to solute?
What is the significance of temperature in controlling the crystallization process, and how does it impact the formation of tablets?
What is the significance of temperature in controlling the crystallization process, and how does it impact the formation of tablets?
What is the role of solubility principles in the crystallization process, and how do they relate to the formation of tablets?
What is the role of solubility principles in the crystallization process, and how do they relate to the formation of tablets?
What was the reason behind the outbreak of toxicity among epileptic patients using phenytoin after the manufacturer switched from calcium sulfate to lactose as the diluent?
What was the reason behind the outbreak of toxicity among epileptic patients using phenytoin after the manufacturer switched from calcium sulfate to lactose as the diluent?
How do the properties of excipients, such as calcium sulfate and lactose, influence the tableting process?
How do the properties of excipients, such as calcium sulfate and lactose, influence the tableting process?
What is the significance of crystal habit and structure in the context of pharmaceutical manufacturing?
What is the significance of crystal habit and structure in the context of pharmaceutical manufacturing?
Why is it important to consider the properties of different grades of the same material when using them as excipients?
Why is it important to consider the properties of different grades of the same material when using them as excipients?
What is the focus of the series of five lectures, and how do they relate to the example of phenytoin manufacturing?
What is the focus of the series of five lectures, and how do they relate to the example of phenytoin manufacturing?
What happens to a stable solution when its concentration is increased?
What happens to a stable solution when its concentration is increased?
How does increasing the temperature of a solution affect its solubility and crystallization?
How does increasing the temperature of a solution affect its solubility and crystallization?
What determines the growth rate and size of crystals?
What determines the growth rate and size of crystals?
What is the relationship between supersaturation and crystallization?
What is the relationship between supersaturation and crystallization?
What is the purpose of metastable region in the context of crystallization?
What is the purpose of metastable region in the context of crystallization?
Describe the sequence of events that occurs when compressing a mass of powder in a tabletting machine.
Describe the sequence of events that occurs when compressing a mass of powder in a tabletting machine.
What happens to the particles in a powder when compressed, and why?
What happens to the particles in a powder when compressed, and why?
What is the outcome of the compression process on the powder, in terms of particle arrangement?
What is the outcome of the compression process on the powder, in terms of particle arrangement?
Why is it important to understand the differences between compressing powder and granules?
Why is it important to understand the differences between compressing powder and granules?
What is the significance of the rearrangement of particles during compression?
What is the significance of the rearrangement of particles during compression?
What happens to particles when they are compressed and deformed under pressure?
What happens to particles when they are compressed and deformed under pressure?
What is sintering, and how does it differ from complete melting?
What is sintering, and how does it differ from complete melting?
What role do chemical reactions play in particle bonding?
What role do chemical reactions play in particle bonding?
How do movable liquids contribute to particle bonding?
How do movable liquids contribute to particle bonding?
What is the purpose of using gelatin or PVP in particle bonding?
What is the purpose of using gelatin or PVP in particle bonding?
What happens when particles are stressed and compressed under pressure?
What happens when particles are stressed and compressed under pressure?
How do surface tension forces contribute to particle bonding?
How do surface tension forces contribute to particle bonding?
What is the difference between sintering and complete melting?
What is the difference between sintering and complete melting?
How do active groups on the surface of particles contribute to chemical reactions?
How do active groups on the surface of particles contribute to chemical reactions?
What is the role of capillary action in movable liquids during particle bonding?
What is the role of capillary action in movable liquids during particle bonding?
Modification of crystalline solid physically or chemically to produce a particle with the desired ______.
Modification of crystalline solid physically or chemically to produce a particle with the desired ______.
Tablets are generally manufactured from a blend of powders, different ______ and they have different properties.
Tablets are generally manufactured from a blend of powders, different ______ and they have different properties.
The ______ of the material will affect the final product's strength during the tabletting process.
The ______ of the material will affect the final product's strength during the tabletting process.
We can also modify the ______ by changing the surface of the particles or the particle size.
We can also modify the ______ by changing the surface of the particles or the particle size.
The ______ properties as well in terms of flow and mixing and dry powder inhalation systems.
The ______ properties as well in terms of flow and mixing and dry powder inhalation systems.
The ______ of the material properties on the tabletting process is a crucial aspect to consider during formulation.
The ______ of the material properties on the tabletting process is a crucial aspect to consider during formulation.
The ______ you know about your material, the better flexibility you will have during formulation.
The ______ you know about your material, the better flexibility you will have during formulation.
This will give you flexibility to change the ______ through this crystal engineering, to change the properties to get the best formulation at the end.
This will give you flexibility to change the ______ through this crystal engineering, to change the properties to get the best formulation at the end.
For example tablet ______, this can have an influence when we change the crystalline properties we can have an influence on the tablet compaction and the mechanical behavior of the material.
For example tablet ______, this can have an influence when we change the crystalline properties we can have an influence on the tablet compaction and the mechanical behavior of the material.
Tablet ______ such as hardness and dissolution can be influenced by the excipients we add in the formulation.
Tablet ______ such as hardness and dissolution can be influenced by the excipients we add in the formulation.
The shape of the powder particles can be _______________, cubic, prismic, blades, or spindles.
The shape of the powder particles can be _______________, cubic, prismic, blades, or spindles.
The particle size distribution is an _______________ factor during the tableting process.
The particle size distribution is an _______________ factor during the tableting process.
The deformation of the material during tableting can be either _______________ or irreversible.
The deformation of the material during tableting can be either _______________ or irreversible.
The capping and lamination of the tablet can occur due to _______________ deformation during manufacturing.
The capping and lamination of the tablet can occur due to _______________ deformation during manufacturing.
The solid properties of the material, including its particle size and shape, affect the _______________ strength of the tablet.
The solid properties of the material, including its particle size and shape, affect the _______________ strength of the tablet.
While compressing a mass of powder, it will change into a compact ______ with a certain shape and dimensions.
While compressing a mass of powder, it will change into a compact ______ with a certain shape and dimensions.
So we are relying on the ______ behavior of the material to make a tablet.
So we are relying on the ______ behavior of the material to make a tablet.
When we fill the dye with granules and start to apply the ______, what will happen?
When we fill the dye with granules and start to apply the ______, what will happen?
When compressing a mass of powder in a tablating machine, the ______ will start with increasing the pressure on the mass of powder inside the dye.
When compressing a mass of powder in a tablating machine, the ______ will start with increasing the pressure on the mass of powder inside the dye.
As the load keeps ______, the particles will keep coming together until there will be no further movement.
As the load keeps ______, the particles will keep coming together until there will be no further movement.
The particles will start to move, become closer to each other, filling the void spaces similar to what powder did in terms of the ______.
The particles will start to move, become closer to each other, filling the void spaces similar to what powder did in terms of the ______.
The more pressure applied from up and down by the punches, the more ______ and clearing of these gaps and void spaces.
The more pressure applied from up and down by the punches, the more ______ and clearing of these gaps and void spaces.
The ______ properties of the material will affect the final product's strength during the tabletting process.
The ______ properties of the material will affect the final product's strength during the tabletting process.
This will force these particles to come ______ to each other.
This will force these particles to come ______ to each other.
This will lead to ______ because at the beginning it’s a porous lump full of gaps, void spaces.
This will lead to ______ because at the beginning it’s a porous lump full of gaps, void spaces.
Increased tablet strength results from smaller original ______ size.
Increased tablet strength results from smaller original ______ size.
If we preserve the ______ size, they will give you a stronger tablet.
If we preserve the ______ size, they will give you a stronger tablet.
The change in ______ area with the increased pressure can be assessed by measuring the change in a specific area of particulate solid.
The change in ______ area with the increased pressure can be assessed by measuring the change in a specific area of particulate solid.
Material properties, such as ______ strength, can be influenced by the original particle size.
Material properties, such as ______ strength, can be influenced by the original particle size.
The relationship between material properties and the tabletting process can be affected by changes in ______ during compaction.
The relationship between material properties and the tabletting process can be affected by changes in ______ during compaction.
The strength of a tablet will vary with ______ size.
The strength of a tablet will vary with ______ size.
The higher the crushing ______, the smaller the particles.
The higher the crushing ______, the smaller the particles.
The ______ of a crystalline solid that can be manipulated include the size and shape.
The ______ of a crystalline solid that can be manipulated include the size and shape.
The pattern for the two materials is the same, but there are ______ between the two materials.
The pattern for the two materials is the same, but there are ______ between the two materials.
The smaller the ______, the higher the crushing strength.
The smaller the ______, the higher the crushing strength.
The surface ______ of the crystalline material can be manipulated.
The surface ______ of the crystalline material can be manipulated.
So how would you expect the ______ of a tablet to vary with particle size?
So how would you expect the ______ of a tablet to vary with particle size?
Let’s start with the ______ size.
Let’s start with the ______ size.
So the higher the ______ strength, the smaller the particles.
So the higher the ______ strength, the smaller the particles.
The ______ of the material during tableting can be either reversible or irreversible.
The ______ of the material during tableting can be either reversible or irreversible.
How does the particle size distribution influence the tableting process?
How does the particle size distribution influence the tableting process?
What is the relationship between surface area and tablet strength?
What is the relationship between surface area and tablet strength?
How does compaction pressure affect the tableting process?
How does compaction pressure affect the tableting process?
What is the significance of material properties in the tableting process?
What is the significance of material properties in the tableting process?
How can changing material properties influence the tabletting process?
How can changing material properties influence the tabletting process?
What is the primary outcome of increasing pressure on a powder during the tableting process?
What is the primary outcome of increasing pressure on a powder during the tableting process?
How does the particle size distribution affect the tablet strength?
How does the particle size distribution affect the tablet strength?
What is the significance of surface area analysis in the context of tablet compaction?
What is the significance of surface area analysis in the context of tablet compaction?
How does the compaction pressure influence the material properties during tableting?
How does the compaction pressure influence the material properties during tableting?
What role do material properties play in the tableting process, and how can they be influenced?
What role do material properties play in the tableting process, and how can they be influenced?
How can the surface area of particles be modified to influence the dissolution rate?
How can the surface area of particles be modified to influence the dissolution rate?
What is the significance of particle size distribution in tablet compaction and mechanical behavior of the material?
What is the significance of particle size distribution in tablet compaction and mechanical behavior of the material?
How can compaction pressure influence the properties of the material during tableting?
How can compaction pressure influence the properties of the material during tableting?
What role do material properties play in the tabletting process, and how can they be manipulated?
What role do material properties play in the tabletting process, and how can they be manipulated?
How can crystal engineering be used to improve the formulation of pharmaceutical products?
How can crystal engineering be used to improve the formulation of pharmaceutical products?
What is the influence of particle size distribution on the tableting process?
What is the influence of particle size distribution on the tableting process?
How does the compaction pressure affect the tablet strength?
How does the compaction pressure affect the tablet strength?
What is the significance of surface area analysis in the context of tableting?
What is the significance of surface area analysis in the context of tableting?
How do material properties influence the tableting process?
How do material properties influence the tableting process?
What is the role of particle shape in the tableting process?
What is the role of particle shape in the tableting process?
What is the primary factor that determines the strength of a tablet, assuming the original particle size is preserved?
What is the primary factor that determines the strength of a tablet, assuming the original particle size is preserved?
How does an increase in compaction pressure affect the surface area of a material during tablet compression?
How does an increase in compaction pressure affect the surface area of a material during tablet compression?
What is the significance of surface area analysis in the context of tablet compaction?
What is the significance of surface area analysis in the context of tablet compaction?
How do changes in material properties during compression affect the tablet strength?
How do changes in material properties during compression affect the tablet strength?
What is the relationship between particle size distribution and tablet strength, assuming the material properties are preserved?
What is the relationship between particle size distribution and tablet strength, assuming the material properties are preserved?
What is the relationship between the crushing force and the crystalline diameter in terms of particle size?
What is the relationship between the crushing force and the crystalline diameter in terms of particle size?
How does the particle size distribution influence the tabletting process?
How does the particle size distribution influence the tabletting process?
What is the effect of compaction pressure on the material properties during tableting?
What is the effect of compaction pressure on the material properties during tableting?
How can the surface area of particles be modified to influence the dissolution rate?
How can the surface area of particles be modified to influence the dissolution rate?
What is the significance of material properties in the tabletting process?
What is the significance of material properties in the tabletting process?
How does the particle size distribution affect the tablet strength?
How does the particle size distribution affect the tablet strength?
What is the role of surface area analysis in the tableting process?
What is the role of surface area analysis in the tableting process?
How does compaction pressure influence the material properties during tableting?
How does compaction pressure influence the material properties during tableting?
What is the significance of particle size in the tableting process?
What is the significance of particle size in the tableting process?
How can modifying the particle size distribution influence the tablet compaction and mechanical behavior of the material?
How can modifying the particle size distribution influence the tablet compaction and mechanical behavior of the material?
What is the significance of particle size distribution during the tableting process?
What is the significance of particle size distribution during the tableting process?
How does the compaction pressure affect the material's properties during tablet formation?
How does the compaction pressure affect the material's properties during tablet formation?
What role do material properties play in the tabletting process?
What role do material properties play in the tabletting process?
What happens to the surface area of particles during compression?
What happens to the surface area of particles during compression?
Why is it important to consider material properties during formulation?
Why is it important to consider material properties during formulation?
