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Questions and Answers
What is the therapeutic class of Prazosin (Minipress)?
What is the therapeutic class of Prazosin (Minipress)?
What is the pharmacologic class of Prazosin (Minipress)?
What is the pharmacologic class of Prazosin (Minipress)?
Adrenergic-blocking drug (rest & digest)
What is the primary expected action of Prazosin (Minipress)?
What is the primary expected action of Prazosin (Minipress)?
Reduce blood pressure by causing rapid decrease in peripheral resistance.
To avoid severe hypotension, give a low 1st dose of Prazosin (Minipress) and identify its safety during pregnancy as Category ___ or lactation is not established.
To avoid severe hypotension, give a low 1st dose of Prazosin (Minipress) and identify its safety during pregnancy as Category ___ or lactation is not established.
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What common side effect is associated with Prazosin (Minipress)?
What common side effect is associated with Prazosin (Minipress)?
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What interactions should be avoided when taking Prazosin (Minipress)?
What interactions should be avoided when taking Prazosin (Minipress)?
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How often is Prazosin (Minipress) typically administered?
How often is Prazosin (Minipress) typically administered?
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What is the mechanism of action of Prazosin (Minipress)?
What is the mechanism of action of Prazosin (Minipress)?
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What is a primary use of Prazosin (Minipress)?
What is a primary use of Prazosin (Minipress)?
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Match the following side effects with their corresponding descriptions:
Match the following side effects with their corresponding descriptions:
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What test results can be falsely elevated by Prazosin (Minipress)?
What test results can be falsely elevated by Prazosin (Minipress)?
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What is the treatment for overdose of Prazosin (Minipress)?
What is the treatment for overdose of Prazosin (Minipress)?
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Study Notes
Prazosin (Minipress) Overview
- Prazosin is classified as an antihypertensive medication, primarily used to lower blood pressure.
- It is an adrenergic-blocking drug that promotes the "rest & digest" state of the body.
Expected Actions & Uses
- Functions as a selective alpha1-adrenergic antagonist, blocking norepinephrine on vascular smooth muscle of arterioles and veins.
- Major action includes a rapid decrease in peripheral resistance, effectively lowering blood pressure without significantly impacting cardiac output or heart rate.
- Less reflex tachycardia compared to other antihypertensive medications.
- Commonly used in combination with beta-blockers or diuretics to enhance antihypertensive effects.
Administration Alerts
- Begin with a low first dose to prevent severe hypotension.
- Safety during pregnancy is categorized as Category C; effects during lactation are not established.
Side Effects
- Orthostatic hypotension, requiring caution in administration timing (preferably at bedtime).
- Possible dizziness or lightheadedness.
- Reflex tachycardia may occur due to rapid blood pressure drops.
- Alpha blockade can lead to nasal congestion.
Drug Interactions
- Concurrent use with other antihypertensives and diuretics may lead to dangerously low blood pressure.
- Alcohol consumption is advised against while taking this medication.
Medication Administration
- Prazosin has a short half-life, necessitating administration two to three times per day for optimal effect.
Mechanism of Action
- Inhibits the sympathetic nervous system, facilitating vasodilation and blood pressure reduction.
Primary Uses
- Indicated for hypertension, dysthymias, angina, heart failure, benign prostate hypertrophy, and narrow-angle glaucoma.
Adverse Effects
- Common adverse reactions include dizziness, drowsiness, headaches, fatigue, palpitations, and dry mouth.
Test Results
- Increases urinary metabolites of vanillylmandelic acid (VMA) and norepinephrine; may lead to false positives when screening for pheochromocytoma (adrenal tumor).
Treatment of Overdose
- Overdose can result in hypotension. Treatment includes fluid expanders like normal saline or vasopressors such as dopamine or dobutamine to stabilize blood pressure.
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Description
This quiz covers the overview of Prazosin (Minipress), its action as an antihypertensive medication, and its expected uses. Learn about its selective alpha1-adrenergic antagonist properties, administration alerts, and potential side effects. Test your knowledge on this important medication!
