Questions and Answers
What is the generic name for Pravachol?
What is the primary drug class of Pravastatin?
Antihyperlipidemic
What are the indications for using Pravastatin?
Hyperlipidemia, decreased risk of myocardial infarction and heart revascularization procedures.
The maximum dosing for Pravastatin is __ mg per day.
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Pravastatin is contraindicated in patients who are pregnant.
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What should patients avoid while taking Pravastatin?
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What is the mechanism of action (MoA) of Pravastatin?
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What are some common adverse effects of Pravastatin?
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Grapefruit juice has a significant effect on the plasma levels of Pravastatin.
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Which of the following medications can increase the risk of myopathy when taken with Pravastatin?
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Patients should consult a doctor immediately if they become __________ during treatment with Pravastatin.
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Study Notes
Pravastatin Overview
- Brand name: Pravachol(R)
- Generic name: Pravastatin Sodium
- Drug class: Antihyperlipidemic
Indications
- Treats hyperlipidemia
- Reduces risk of myocardial infarction (MI)
- Lowers coronary death rates
- Aids in myocardial revascularization procedures
- Specifically indicated for:
- Elevated total and LDL cholesterol
- Apolipoprotein B
- Triglyceride levels in primary hypercholesterolemia
- Mixed dyslipidemia
- Heterozygous familial hypercholesterolemia
Mechanism of Action (MoA)
- Functions as an HMG-CoA reductase inhibitor
- Decreases cholesterol synthesis from mevalonate
- Lowers LDL levels and raises HDL levels while maintaining necessary cholesterol production
Dosing Information
- Initial dose: 10 to 20 mg once daily, preferably at bedtime
- Maximum daily dose: 40 mg
Contraindications
- Not suitable for pregnant or lactating women
- Patients with liver disease
- Elevated liver enzymes (AST or ALT)
Pregnancy Category
- Category X: Proven fetal risk and contraindicated during pregnancy
Patient Counseling
- Avoid alcohol consumption
- Do not double doses if a dose is missed
- Shield from overexposure to sunlight
- Contact healthcare provider if experiencing symptoms of myopathy
- Avoid pregnancy during treatment
Adverse Drug Reactions (ADRs)
- Common side effects include:
- Rash
- Muscle pain (myalgia)
- Headache (HA)
- Dyspepsia
- Influenza-like symptoms
Drug Interactions
- Caution with:
- Gemfibrozil: May cause severe myopathy or rhabdomyolysis
- Nicotinic acid
- Erythromycin
- Immunosuppressive agents
- Coadministration with cholestyramine or colestipol can enhance lipid-lowering effects, but absorption may decrease. These medications should be taken 1 hour before or 4 hours after pravastatin.
- Grapefruit juice has minimal effect on plasma levels.
Additional Patient Considerations
- Consult with healthcare provider immediately if symptoms of myopathy occur, especially if accompanied by pain or fever.
- Adhere to prescribed diet and limit sun exposure—use sunscreen when necessary.
- Avoid alcohol; store in a cool, dry place and out of reach of children.
- If a dose is missed, take as soon as remembered, unless it's close to the next scheduled dose—skip the missed dose in that case.
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Description
Test your knowledge on Pravastatin, commonly known as Pravachol. This quiz covers its indications, drug class, dosing guidelines, and contraindications. Perfect for healthcare professionals and students looking to enhance their understanding of this important antihyperlipidemic medication.
