Prasugrel Drug Flashcards

Questions and Answers

What is the brand name of Prasugrel?

Effient (correct)

Aspirin

Brilinta

Plavix

What is the drug class of Prasugrel?

Antiplatelet Agent

What are the routes of administration of Prasugrel?

Oral Tablet: 5 mg, 10 mg

What are the common indications and dosing of Prasugrel?

Prevention of thromboembolism after percutaneous coronary intervention: 60 mg po once (with aspirin 162-325 mg), then 10 mg po daily, in combination with aspirin 75-325 mg po daily Signup and view all the answers

What is the Mechanism of Action of Prasugrel?

Inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets. Signup and view all the answers

What is the dose adjustment renal for Prasugrel?

NONE Signup and view all the answers

Are there pharmacogenetics for Prasugrel?

False Signup and view all the answers

What are the contraindications to Prasugrel?

Active bleeding, history of transient ischemic attack or stroke Signup and view all the answers

What are the black box warnings for Prasugrel?

Bleeding risk; not recommended in patients ≥75 y of age; CABG Signup and view all the answers

What are the drug interactions with Prasugrel?

SSRIs, Antiplatelet agents, NSAIDs, Anticoagulants Signup and view all the answers

What are COMMON adverse reactions with Prasugrel?

NONE Signup and view all the answers

What are RARE BUT SERIOUS adverse reactions with Prasugrel?

Atrial fibrillation, colon cancer, major bleeding, TTP, angioedema Signup and view all the answers

What are the Efficacy Monitoring Parameters for Prasugrel?

Stent patency and prevention of clotting. Signup and view all the answers

What are the Toxicity Monitoring Parameters for Prasugrel?

Monitor for signs and symptoms of bleeding. Consider periodic hematocrit/hemoglobin, as well as platelet function testing. Signup and view all the answers

Study Notes

Prasugrel Overview

Brand name: Effient
Classification: Antiplatelet Agent

Administration and Dosing

Available as oral tablets in dosages of 5 mg and 10 mg.
Commonly used for preventing thromboembolism after percutaneous coronary intervention.
Initial dose: 60 mg orally once (in conjunction with aspirin 162-325 mg).
Maintenance dose: 10 mg orally daily, along with aspirin 75-325 mg daily.

Mechanism of Action

Functions as an inhibitor of platelet activation and aggregation.
Works by irreversibly binding its active metabolite to P2Y12 ADP receptors on platelets.

Renal Considerations

No renal dose adjustments required for Prasugrel.

Pharmacogenetics

No significant effect of genetic variations in CYP2B6, 2C9, 2C19, or 3A4/5 on the drug's efficacy.

Contraindications

Prohibited in individuals with active bleeding.
Not to be used in patients with a history of transient ischemic attack or stroke.

Black Box Warnings

Notable concerns regarding bleeding risk.
Use is not recommended for patients aged 75 years or older.
Caution advised for patients undergoing coronary artery bypass grafting (CABG).

Drug Interactions

Potential interactions with SSRIs, other antiplatelet agents, NSAIDs, and anticoagulants.

Adverse Reactions

Common adverse reactions are not significant; no common adverse effects noted.
Rare but serious reactions include:
- Atrial fibrillation
- Colon cancer
- Major bleeding
- Thrombotic thrombocytopenic purpura (TTP)
- Angioedema

Monitoring Parameters

Efficacy monitoring parameters include stent patency and clot prevention.
Toxicity monitoring involves checking for signs and symptoms of bleeding and considering regular hematocrit/hemoglobin assessments and platelet function testing.

Description

Test your knowledge of Prasugrel with these flashcards. Explore key information such as its brand name, drug class, routes of administration, and common medical indications. Perfect for students and professionals in pharmacy and medicine.