Questions and Answers
What is the brand name of Prasugrel?
What is the drug class of Prasugrel?
Antiplatelet Agent
What are the routes of administration of Prasugrel?
Oral Tablet: 5 mg, 10 mg
What are the common indications and dosing of Prasugrel?
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What is the Mechanism of Action of Prasugrel?
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What is the dose adjustment renal for Prasugrel?
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Are there pharmacogenetics for Prasugrel?
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What are the contraindications to Prasugrel?
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What are the black box warnings for Prasugrel?
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What are the drug interactions with Prasugrel?
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What are COMMON adverse reactions with Prasugrel?
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What are RARE BUT SERIOUS adverse reactions with Prasugrel?
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What are the Efficacy Monitoring Parameters for Prasugrel?
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What are the Toxicity Monitoring Parameters for Prasugrel?
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Study Notes
Prasugrel Overview
- Brand name: Effient
- Classification: Antiplatelet Agent
Administration and Dosing
- Available as oral tablets in dosages of 5 mg and 10 mg.
- Commonly used for preventing thromboembolism after percutaneous coronary intervention.
- Initial dose: 60 mg orally once (in conjunction with aspirin 162-325 mg).
- Maintenance dose: 10 mg orally daily, along with aspirin 75-325 mg daily.
Mechanism of Action
- Functions as an inhibitor of platelet activation and aggregation.
- Works by irreversibly binding its active metabolite to P2Y12 ADP receptors on platelets.
Renal Considerations
- No renal dose adjustments required for Prasugrel.
Pharmacogenetics
- No significant effect of genetic variations in CYP2B6, 2C9, 2C19, or 3A4/5 on the drug's efficacy.
Contraindications
- Prohibited in individuals with active bleeding.
- Not to be used in patients with a history of transient ischemic attack or stroke.
Black Box Warnings
- Notable concerns regarding bleeding risk.
- Use is not recommended for patients aged 75 years or older.
- Caution advised for patients undergoing coronary artery bypass grafting (CABG).
Drug Interactions
- Potential interactions with SSRIs, other antiplatelet agents, NSAIDs, and anticoagulants.
Adverse Reactions
- Common adverse reactions are not significant; no common adverse effects noted.
- Rare but serious reactions include:
- Atrial fibrillation
- Colon cancer
- Major bleeding
- Thrombotic thrombocytopenic purpura (TTP)
- Angioedema
Monitoring Parameters
- Efficacy monitoring parameters include stent patency and clot prevention.
- Toxicity monitoring involves checking for signs and symptoms of bleeding and considering regular hematocrit/hemoglobin assessments and platelet function testing.
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