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Questions and Answers
What is the brand name of Prasugrel?
What is the brand name of Prasugrel?
What is the drug class of Prasugrel?
What is the drug class of Prasugrel?
Antiplatelet Agent
What are the routes of administration of Prasugrel?
What are the routes of administration of Prasugrel?
Oral Tablet: 5 mg, 10 mg
What are the common indications and dosing of Prasugrel?
What are the common indications and dosing of Prasugrel?
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What is the Mechanism of Action of Prasugrel?
What is the Mechanism of Action of Prasugrel?
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What is the dose adjustment renal for Prasugrel?
What is the dose adjustment renal for Prasugrel?
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Are there pharmacogenetics for Prasugrel?
Are there pharmacogenetics for Prasugrel?
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What are the contraindications to Prasugrel?
What are the contraindications to Prasugrel?
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What are the black box warnings for Prasugrel?
What are the black box warnings for Prasugrel?
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What are the drug interactions with Prasugrel?
What are the drug interactions with Prasugrel?
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What are COMMON adverse reactions with Prasugrel?
What are COMMON adverse reactions with Prasugrel?
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What are RARE BUT SERIOUS adverse reactions with Prasugrel?
What are RARE BUT SERIOUS adverse reactions with Prasugrel?
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What are the Efficacy Monitoring Parameters for Prasugrel?
What are the Efficacy Monitoring Parameters for Prasugrel?
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What are the Toxicity Monitoring Parameters for Prasugrel?
What are the Toxicity Monitoring Parameters for Prasugrel?
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Study Notes
Prasugrel Overview
- Brand name: Effient
- Classification: Antiplatelet Agent
Administration and Dosing
- Available as oral tablets in dosages of 5 mg and 10 mg.
- Commonly used for preventing thromboembolism after percutaneous coronary intervention.
- Initial dose: 60 mg orally once (in conjunction with aspirin 162-325 mg).
- Maintenance dose: 10 mg orally daily, along with aspirin 75-325 mg daily.
Mechanism of Action
- Functions as an inhibitor of platelet activation and aggregation.
- Works by irreversibly binding its active metabolite to P2Y12 ADP receptors on platelets.
Renal Considerations
- No renal dose adjustments required for Prasugrel.
Pharmacogenetics
- No significant effect of genetic variations in CYP2B6, 2C9, 2C19, or 3A4/5 on the drug's efficacy.
Contraindications
- Prohibited in individuals with active bleeding.
- Not to be used in patients with a history of transient ischemic attack or stroke.
Black Box Warnings
- Notable concerns regarding bleeding risk.
- Use is not recommended for patients aged 75 years or older.
- Caution advised for patients undergoing coronary artery bypass grafting (CABG).
Drug Interactions
- Potential interactions with SSRIs, other antiplatelet agents, NSAIDs, and anticoagulants.
Adverse Reactions
- Common adverse reactions are not significant; no common adverse effects noted.
- Rare but serious reactions include:
- Atrial fibrillation
- Colon cancer
- Major bleeding
- Thrombotic thrombocytopenic purpura (TTP)
- Angioedema
Monitoring Parameters
- Efficacy monitoring parameters include stent patency and clot prevention.
- Toxicity monitoring involves checking for signs and symptoms of bleeding and considering regular hematocrit/hemoglobin assessments and platelet function testing.
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Test your knowledge of Prasugrel with these flashcards. Explore key information such as its brand name, drug class, routes of administration, and common medical indications. Perfect for students and professionals in pharmacy and medicine.
