Prasugrel Drug Flashcards

Prasugrel Overview

• Brand name: Effient
• Classification: Antiplatelet Agent

Administration and Dosing

• Available as oral tablets in dosages of 5 mg and 10 mg.
• Commonly used for preventing thromboembolism after percutaneous coronary intervention.
• Initial dose: 60 mg orally once (in conjunction with aspirin 162-325 mg).
• Maintenance dose: 10 mg orally daily, along with aspirin 75-325 mg daily.

Mechanism of Action

• Functions as an inhibitor of platelet activation and aggregation.
• Works by irreversibly binding its active metabolite to P2Y12 ADP receptors on platelets.

Renal Considerations

• No renal dose adjustments required for Prasugrel.

Pharmacogenetics

• No significant effect of genetic variations in CYP2B6, 2C9, 2C19, or 3A4/5 on the drug's efficacy.

Contraindications

• Prohibited in individuals with active bleeding.
• Not to be used in patients with a history of transient ischemic attack or stroke.

Black Box Warnings

• Notable concerns regarding bleeding risk.
• Use is not recommended for patients aged 75 years or older.
• Caution advised for patients undergoing coronary artery bypass grafting (CABG).

Drug Interactions

• Potential interactions with SSRIs, other antiplatelet agents, NSAIDs, and anticoagulants.

Adverse Reactions

• Common adverse reactions are not significant; no common adverse effects noted.
• Rare but serious reactions include:
  • Atrial fibrillation
  • Colon cancer
  • Major bleeding
  • Thrombotic thrombocytopenic purpura (TTP)
  • Angioedema

Monitoring Parameters

• Efficacy monitoring parameters include stent patency and clot prevention.
• Toxicity monitoring involves checking for signs and symptoms of bleeding and considering regular hematocrit/hemoglobin assessments and platelet function testing.