18 Questions
What is the function of the 5' cap in eukaryotic mRNAs?
Signals the start of translation by forming a binding site for the ribosome
What is the linkage between 7-Methylguanosine and the 5' end of almost all eukaryotic mRNAs?
5'-5' triphosphate linkage
What does the presence of introns in genes signify?
They are present in most genes in vertebrates and some in yeast
Where is the capbinding complex (CBC) associated during the synthesis of the 5' cap?
Tethered to Pol II through an association with the CTD
What is one of the post-transcriptional processes involved in RNA processing?
Splicing out introns
When does the addition of a 5'-cap occur in eukaryotic cells occur?
Before synthesis of the primary transcript is complete
What is the function of splicing in post-transcriptional RNA processing?
Removing introns and attaching exons
Where does processing of eukaryotic mRNA take place?
In the nucleus
What are the three main processes involved in forming mature mRNA from a primary transcript in eukaryotes?
Capping, polyadenylation, splicing
What is the function of a 3’-poly(A) tail in mRNA processing?
Prevents mRNA degradation
Where does splicing occur during post-transcriptional RNA processing in eukaryotes?
Nucleus
Which process of RNA processing involves removing introns and joining exons together?
Splicing
When does the addition of a 5' cap to eukaryotic mRNAs typically occur?
During transcription
What is the source of methyl groups often found at the 2' position of the first and second nucleotides in eukaryotic mRNAs?
S-adenosyl-methionine (SAM)
Which complex is associated with the capbinding complex (CBC) during the synthesis of the 5' cap?
Capbinding complex
What is the role of introns in most genes in vertebrates?
Contribute to genetic variation
What post-transcriptional modification is involved in removing introns from pre-mRNA in eukaryotes?
Splicing
What is the function of methylguanosine at the 5' end of eukaryotic mRNAs?
Facilitates translation initiation
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