Podcast
Questions and Answers
What is a porphin?
What is a porphin?
- A type of hereditary disease
- A cyclic compound formed by the linkage of 4 pyrrole rings (correct)
- A protein that contains heme as a prosthetic group
- A complex of one porphyrin and ferrous iron
What is the function of the heme group in hemoglobin and myoglobin?
What is the function of the heme group in hemoglobin and myoglobin?
- To interact with oxygen and form damage oxygen radicles
- To reversibly bind oxygen (correct)
- To catalyze the breakdown of hydrogen peroxide
- To serve as an electron carrier
What is the result of a deficiency of one of the enzymes needed for heme synthesis?
What is the result of a deficiency of one of the enzymes needed for heme synthesis?
- Increased production and excretion of porphyrins and/or their precursors (correct)
- Decreased production and excretion of porphyrins and/or their precursors
- Only increased production of porphyrins
- No effect on porphyrins and/or their precursors
What type of porphyria is caused by lead poisoning?
What type of porphyria is caused by lead poisoning?
What is the function of the heme group in catalase?
What is the function of the heme group in catalase?
What is the result of anemia in patients with porphyria?
What is the result of anemia in patients with porphyria?
What is the result of photosensitivity in patients with porphyria?
What is the result of photosensitivity in patients with porphyria?
What is the inheritance pattern of congenital erythropoietic porphyria?
What is the inheritance pattern of congenital erythropoietic porphyria?
What is the primary function of myoglobin in muscle cells?
What is the primary function of myoglobin in muscle cells?
What is the structure of the myoglobin molecule?
What is the structure of the myoglobin molecule?
How many oxygen molecules can myoglobin bind?
How many oxygen molecules can myoglobin bind?
What is the partial pressure of oxygen needed to achieve half-saturation of the binding sites on myoglobin?
What is the partial pressure of oxygen needed to achieve half-saturation of the binding sites on myoglobin?
What happens to the oxygen dissociation curve when the pH is raised or the concentration of CO2 in the lungs is lowered?
What happens to the oxygen dissociation curve when the pH is raised or the concentration of CO2 in the lungs is lowered?
What is the Bohr effect?
What is the Bohr effect?
What happens to the oxygen dissociation curve in the Bohr effect?
What happens to the oxygen dissociation curve in the Bohr effect?
What is the effect of 2,3-bisphosphoglycerate (2,3 BPG) on the oxygen affinity of hemoglobin?
What is the effect of 2,3-bisphosphoglycerate (2,3 BPG) on the oxygen affinity of hemoglobin?
What is the purpose of 2,3-BPG in the RBCs?
What is the purpose of 2,3-BPG in the RBCs?
What is the primary difference in oxygen binding between myoglobin and hemoglobin?
What is the primary difference in oxygen binding between myoglobin and hemoglobin?
What happens to the oxygen affinity of hemoglobin in the absence of 2,3-BPG?
What happens to the oxygen affinity of hemoglobin in the absence of 2,3-BPG?
What is the function of the heme group in myoglobin?
What is the function of the heme group in myoglobin?
What is the function of Hb A2?
What is the function of Hb A2?
What can happen to Hb A?
What can happen to Hb A?
What occurs due to an imbalance in the synthesis of globin chains in thalassemias?
What occurs due to an imbalance in the synthesis of globin chains in thalassemias?
What leads to the formation of α2β2 (Hb A) in normal conditions?
What leads to the formation of α2β2 (Hb A) in normal conditions?
Which enzyme catalyzes the first step in the degradation of heme?
Which enzyme catalyzes the first step in the degradation of heme?
What pigment is produced as a result of the first step in the degradation of heme?
What pigment is produced as a result of the first step in the degradation of heme?
How is bilirubin transported to the liver?
How is bilirubin transported to the liver?
What increases the solubility of bilirubin in the hepatocyte?
What increases the solubility of bilirubin in the hepatocyte?
What is formed when bilirubin diglucuronide is hydrolyzed and reduced by bacteria in the gut?
What is formed when bilirubin diglucuronide is hydrolyzed and reduced by bacteria in the gut?
What is the primary location where red blood cells are degraded after approximately 120 days in circulation?
What is the primary location where red blood cells are degraded after approximately 120 days in circulation?
What pigment gives feces its characteristic brown color?
What pigment gives feces its characteristic brown color?
What is the main cause of hemolytic jaundice?
What is the main cause of hemolytic jaundice?
What is the fate of reabsorbed urobilinogen in the portal blood?
What is the fate of reabsorbed urobilinogen in the portal blood?
Which type of jaundice involves an obstruction of the bile duct?
Which type of jaundice involves an obstruction of the bile duct?
What causes the urine to turn dark in hepatocellular jaundice?
What causes the urine to turn dark in hepatocellular jaundice?
Why do newborns often develop jaundice?
Why do newborns often develop jaundice?
What enzyme's activity is low at birth, contributing to jaundice in newborns?
What enzyme's activity is low at birth, contributing to jaundice in newborns?
What is the end product of heme catabolism?
What is the end product of heme catabolism?