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Polymyositis Diagnosis

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Questions and Answers

What is the percentage of patients with normal serum creatine kinase levels in dermatomyositis?

30%

40%

20%

10% (correct)

What is the characteristic feature of muscle biopsy in dermatomyositis?

Fibrosis is the primary feature

Perifascicular atrophy is present in all patients

Perifascicular atrophy is present in only 50% of patients (correct)

Muscle inflammation is absent

What is the specific antibody associated with amyopathic dermatomyositis?

Anti-Mi2

Anti-MDA5 (correct)

Anti-NXP2

Anti-TIF1

What is the most common inflammatory cell found in muscle biopsy in dermatomyositis?

Macrophages Signup and view all the answers

What is the prognosis of dermatomyositis in the absence of malignancy?

Favorable Signup and view all the answers

What is the primary goal of exercise therapy in dermatomyositis?

To improve muscle function Signup and view all the answers

What is the primary mechanism by which dermatomyositis is mediated?

Complement activation Signup and view all the answers

What is the characteristic rash of dermatomyositis that is pathognomonic for the disease?

Gottron sign Signup and view all the answers

What is the primary pattern of muscle weakness in dermatomyositis?

Symmetric proximal weakness Signup and view all the answers

What is the role of creatine kinase in the diagnosis of dermatomyositis?

It is a sensitive laboratory marker for muscle destruction Signup and view all the answers

What is the main characteristic of Dermatomyositis?

An immune-mediated disease that attacks the muscles in the body Signup and view all the answers

Which of the following is a characteristic feature of Dermatomyositis?

Symmetric proximal weakness without cutaneous lesion Signup and view all the answers

What is the underlying pathogenesis of dermatomyositis?

Autoimmune disease Signup and view all the answers

What is the characteristic skin rash that occurs over the extensor surfaces of joints in dermatomyositis?

Gottron papules Signup and view all the answers

What is the significance of increased CK levels in Dermatomyositis?

It is an indication of muscle damage and inflammation Signup and view all the answers

What is the percentage of cancer risk associated with Dermatomyositis?

15% within the first 2-3 years Signup and view all the answers

What is the significance of Gottron papules in Dermatomyositis?

It is a characteristic skin lesion of Dermatomyositis Signup and view all the answers

What is the main reason for screening for cancer in patients with Dermatomyositis?

Because Dermatomyositis can be paraneoplastic Signup and view all the answers