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Polygenic Inheritance of Schizophrenia

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Questions and Answers

Which of the following best describes the inheritance pattern of schizophrenia?

Schizophrenia is not influenced by genetic factors.

Schizophrenia is caused by a single gene with dominant inheritance.

Schizophrenia involves polygenic inheritance with additive effects. (correct)

Schizophrenia is caused by a single gene with recessive inheritance.

What do genes cause in relation to schizophrenia?

Genes only cause schizophrenia in combination with environmental factors.

Genes cause subtle molecular changes in proteins and cells that may bias the individual towards psychosis. (correct)

Genes cause schizophrenia and its symptoms directly.

Genes do not have any effect on schizophrenia.

Which of the following is a frequent endophenotype in schizophrenia?

Enlarged lateral ventricles (correct)

Enlarged frontal lobes

Increased white matter connectivity

Reduced gray matter volume

Study Notes

Schizophrenia Inheritance Pattern

Schizophrenia exhibits a complex inheritance pattern, influenced by multiple genetic and environmental factors.

Genetic Role in Schizophrenia

Genes contribute to the development of schizophrenia, but do not solely cause the disorder.
Genetic factors increase the risk of developing schizophrenia, but do not guarantee its onset.

Endophenotypes in Schizophrenia

A frequent endophenotype in schizophrenia is smooth pursuit eye movement abnormality, which is characterized by difficulties in tracking moving objects smoothly.

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Description

Test your knowledge of the polygenic inheritance of schizophrenia and its role in determining the phenotype. Explore the cumulative effects of multiple genes and the influence of the environment on vulnerability for this complex disorder.