Podcast
Questions and Answers
What is absolute polycythemia primarily characterized by?
What is absolute polycythemia primarily characterized by?
- Increased plasma volume
- Decreased total red blood cell mass
- Normal hematocrit levels
- Elevated total red blood cell mass (correct)
Which condition would lead to secondary polycythemia with appropriately elevated EPO production?
Which condition would lead to secondary polycythemia with appropriately elevated EPO production?
- Dehydration
- High altitude (correct)
- Shock
- Renal carcinoma
In relative polycythemia, what is the primary reason for the increased hematocrit?
In relative polycythemia, what is the primary reason for the increased hematocrit?
- Increased oxygen saturation
- Increased red blood cell mass
- Decreased total hemoglobin
- Decreased plasma volume (correct)
Which of the following is NOT associated with secondary polycythemia?
Which of the following is NOT associated with secondary polycythemia?
What distinguishes secondary polycythemia with inappropriately elevated EPO production?
What distinguishes secondary polycythemia with inappropriately elevated EPO production?
Flashcards
MCV
MCV
Mean Corpuscular Volume, average volume of red blood cells (RBCs).
MCH
MCH
Mean Corpuscular Hemoglobin, average amount of hemoglobin in each RBC.
MCHC
MCHC
Mean Corpuscular Hemoglobin Concentration, average concentration of hemoglobin in each RBC.
Polycythemia
Polycythemia
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Absolute Polycythemia
Absolute Polycythemia
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Relative Polycythemia
Relative Polycythemia
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Secondary Polycythemia (with appropriately EPO production)
Secondary Polycythemia (with appropriately EPO production)
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Secondary Polycythemia (with inappropriately EPO production)
Secondary Polycythemia (with inappropriately EPO production)
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RBC count
RBC count
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Hematocrit
Hematocrit
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Hemoglobin (Hb)
Hemoglobin (Hb)
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Study Notes
Polycythemia
- Defined clinically as an increased hematocrit level above normal
- Occurs when hemoglobin and RBC count are elevated (reflecting an increase in total erythrocyte volume)
- Two main types: absolute and relative
Absolute Polycythemia
- Elevated total red blood cell mass
- Subtypes:
- Secondary polycythemia with appropriately EPO production
- Causes: decreased oxygen loading (e.g., hypoxia, high altitude, certain diseases), decreased oxygen unloading (high oxygen affinity hemoglobinopathy, etc.),
- Secondary polycythemia with inappropriately elevated EPO production
- Causes: neoplasms (e.g., Wilms' tumor, renal carcinoma), localized tissue hypoxia (e.g., polycystic kidney disease), post-renal transplant, or acute hepatitis
- Secondary polycythemia with appropriately EPO production
Relative Polycythemia
- Normal total red blood cell mass
- Decreased plasma volume
- Causes: dehydration, or shock
- Spurious polycythemia (stress polycythemia, Gaisböck's syndrome)
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