Podcast
Questions and Answers
What is the main focus of histone modification in normal cells?
What is the main focus of histone modification in normal cells?
- Producing energy for the cell
- Regulating cell division
- Repairing damaged DNA
- Regulating access to genes (correct)
According to the learning outcomes, which of the following is a key aspect of nucleosome structure?
According to the learning outcomes, which of the following is a key aspect of nucleosome structure?
- DNA replication process
- Polycomb and trithorax protein functions
- Cell differentiation mechanisms
- Dynamic nature of chromatin structure (correct)
How do cells differentiate and maintain their identity according to the learning outcomes?
How do cells differentiate and maintain their identity according to the learning outcomes?
- By altering their DNA sequences
- Through epigenetic mechanisms (correct)
- By changing their cell types frequently
- Through metabolic processes
What are histones subjected to in normal cells?
What are histones subjected to in normal cells?
What is the main function of polycomb and trithorax proteins according to the learning outcomes?
What is the main function of polycomb and trithorax proteins according to the learning outcomes?
How can cell differentiation pathways be conceptualized, based on the given information?
How can cell differentiation pathways be conceptualized, based on the given information?
What is the effect of EZH2 inhibition on DLBCL cells?
What is the effect of EZH2 inhibition on DLBCL cells?
Which gene mutation is associated with reduction in the level of H3K27me3 and an increase in H3K27ac?
Which gene mutation is associated with reduction in the level of H3K27me3 and an increase in H3K27ac?
Which inhibitors can block DIPG tumor growth?
Which inhibitors can block DIPG tumor growth?
What is the effect of gain-of-function EZH2 mutations?
What is the effect of gain-of-function EZH2 mutations?
Which histone modifier is implicated in maintaining cell identity and regulating transcription in cancer?
Which histone modifier is implicated in maintaining cell identity and regulating transcription in cancer?
What is the role of BET domain protein inhibitors?
What is the role of BET domain protein inhibitors?
Which genes exhibit increased H3K27me3 despite H3K27M mutations?
Which genes exhibit increased H3K27me3 despite H3K27M mutations?
What is the main function of Polycomb group proteins (PRC2 and PRC1) in the context of cell differentiation?
What is the main function of Polycomb group proteins (PRC2 and PRC1) in the context of cell differentiation?
Which statement about Trithorax (Trx) and MLL1 is true?
Which statement about Trithorax (Trx) and MLL1 is true?
What is the effect of histone acetylation on chromatin structure?
What is the effect of histone acetylation on chromatin structure?
How can alterations to histone mark writers, readers, and erasers cause cancer?
How can alterations to histone mark writers, readers, and erasers cause cancer?
What is the effect of MLL-AF4 fusion protein in leukemic cells?
What is the effect of MLL-AF4 fusion protein in leukemic cells?
Which statement about BRD4 inhibitors is true?
Which statement about BRD4 inhibitors is true?
What is the impact of EZH2-Y641F mutations on gene expression in B cell lymphoma?
What is the impact of EZH2-Y641F mutations on gene expression in B cell lymphoma?
What is the role of EZH2 histone methyltransferase inhibitors in blocking the growth of certain tumor types?
What is the role of EZH2 histone methyltransferase inhibitors in blocking the growth of certain tumor types?
How do alterations to histone mark writers, readers, and erasers contribute to cancer?
How do alterations to histone mark writers, readers, and erasers contribute to cancer?
What is the impact of EZH2 gain-of-function mutations on gene expression in B cell lymphoma?
What is the impact of EZH2 gain-of-function mutations on gene expression in B cell lymphoma?
What is the main function of Polycomb group proteins (PRC2 and PRC1) in maintaining cell identity during differentiation?
What is the main function of Polycomb group proteins (PRC2 and PRC1) in maintaining cell identity during differentiation?
What is the definition of epigenetics?
What is the definition of epigenetics?
What is the main function of chromatin?
What is the main function of chromatin?
What is the composition of a nucleosome?
What is the composition of a nucleosome?
What is the role of closed chromatin (heterochromatin) in gene transcription?
What is the role of closed chromatin (heterochromatin) in gene transcription?
What is the effect of histone acetylation on chromatin structure?
What is the effect of histone acetylation on chromatin structure?
Which enzymes add histone marks to specific lysine residues?
Which enzymes add histone marks to specific lysine residues?
What is the main function of Polycomb group proteins (PRC2 and PRC1) in regulating gene expression?
What is the main function of Polycomb group proteins (PRC2 and PRC1) in regulating gene expression?
What does the balance between Polycomb and Trithorax proteins regulate?
What does the balance between Polycomb and Trithorax proteins regulate?
How does DNA methylation affect transcription?
How does DNA methylation affect transcription?
What is the role of nucleosome remodelling in allowing transcription to proceed?
What is the role of nucleosome remodelling in allowing transcription to proceed?
What is the impact of histone methylation on gene expression?
What is the impact of histone methylation on gene expression?
What are the primary readers of histone modifications?
What are the primary readers of histone modifications?
