Pneumonia Treatment Options
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Questions and Answers

Which of the following is NOT a criterion for prescribing Paxlovid or Molnupiravir?

  • Patient has severe COVID-19 symptoms. (correct)
  • Treatment can be started within 5 days of symptom onset.
  • Patient is at risk for severe illness.
  • Patient is over the age of 12.

A patient is admitted to the non-ICU setting with community-acquired pneumonia (CAP). Initial treatment options include all EXCEPT which of the following?

  • Respiratory fluoroquinolone
  • Vancomycin monotherapy (correct)
  • Beta-lactam plus doxycycline
  • Beta-lactam plus a macrolide

A patient with a known penicillin allergy requires inpatient treatment for community-acquired pneumonia (CAP) in the ICU. Which of the following antibiotic regimens is most appropriate?

  • Piperacillin/tazobactam plus vancomycin
  • Ceftriaxone plus azithromycin
  • Ampicillin/sulbactam plus doxycycline
  • Aztreonam plus a respiratory fluoroquinolone (correct)

Which beta-lactam antibiotic provides Pseudomonas coverage?

<p>Ceftazidime (A)</p> Signup and view all the answers

A patient is being treated for community-acquired pneumonia and is not responding to initial antibiotic therapy after 60 hours. What is the most appropriate next step in management?

<p>Re-evaluate the patient, considering alternative diagnoses or complications. (D)</p> Signup and view all the answers

For uncomplicated pneumonia patients, what is the typical duration of antibiotic treatment, assuming they respond well to the therapy?

<p>5 days (D)</p> Signup and view all the answers

Which antibiotic regimen is most appropriate for an adult outpatient with community-acquired pneumonia (CAP) and no comorbidities or risk factors for drug-resistant Streptococcus pneumoniae?

<p>Amoxicillin 1 g three times a day. (A)</p> Signup and view all the answers

Before discontinuing antibiotic therapy for pneumonia, a patient should be afebrile for how long?

<p>48-72 hours (A)</p> Signup and view all the answers

Which of the following is a recommended preventative measure for high-risk pneumonia patients?

<p>Pneumococcal vaccine (A)</p> Signup and view all the answers

An adult outpatient presents with CAP and has a history of antimicrobial use within the past 90 days. Which empiric treatment would be most appropriate?

<p>Levofloxacin 750 mg daily. (D)</p> Signup and view all the answers

What is the recommended first-line antibiotic agent for children under 5 years old with uncomplicated community-acquired pneumonia?

<p>High-dose amoxicillin (A)</p> Signup and view all the answers

Which of the following is the most common microbiological finding in lung abscesses?

<p>Mixed anaerobic bacteria (D)</p> Signup and view all the answers

A patient with a history of alcoholism is diagnosed with a lung abscess. Which of the following contributing factors is most likely associated with this condition?

<p>Compromised gag reflex (D)</p> Signup and view all the answers

In children aged 5-16 years with community-acquired pneumonia, which class of antibiotics is typically preferred to cover atypical pathogens like Mycoplasma pneumoniae?

<p>Macrolides (D)</p> Signup and view all the answers

Which of the following antibiotic classes is typically used to treat lung abscesses to ensure coverage against anaerobic bacteria?

<p>Beta-lactam or beta-lactamase inhibitor (C)</p> Signup and view all the answers

Why are tetracyclines and fluoroquinolones generally avoided in pediatric patients with community-acquired pneumonia?

<p>Risk of tendon rupture and teeth staining, respectively (B)</p> Signup and view all the answers

During influenza season, which antiviral medication is LEAST likely to be considered as an initial treatment for an outpatient presenting with pneumonia and flu-like symptoms?

<p>Ciprofloxacin (A)</p> Signup and view all the answers

What is the primary mechanism by which cystic fibrosis leads to bronchiectasis?

<p>Excessive mucus production and impaired mucociliary clearance (D)</p> Signup and view all the answers

A patient with bronchiectasis presents with hemoptysis and recurrent lower respiratory tract infections. Bronchiectasis results in abnormal and permanent dilation of the bronchi. Which of the following mechanisms is least likely to contribute directly to the pathogenesis of bronchiectasis?

<p>Impaired T-cell function (D)</p> Signup and view all the answers

A non-hospitalized patient tests positive for COVID-19 and is at high risk for severe disease. Which treatment option directly targets the virus to reduce the risk of hospitalization?

<p>Monoclonal antibody bebtelovimab (C)</p> Signup and view all the answers

A previously healthy 6-year-old child presents with a 2-day history of fever, cough, and mild shortness of breath. Auscultation reveals decreased breath sounds in the left lower lobe. The child is up-to-date on all vaccinations. Considering the likely causative organisms and current guidelines, what is an appropriate empiric treatment approach?

<p>High-dose amoxicillin, targeting <em>Streptococcus pneumoniae</em> as the most likely pathogen. (C)</p> Signup and view all the answers

Which of the following radiographic findings might be observed on a chest X-ray (CXR) of a patient with a pulmonary fungal infection?

<p>All of the above (D)</p> Signup and view all the answers

In which patient population are fungal pulmonary infections most commonly observed?

<p>Immunocompromised patients (A)</p> Signup and view all the answers

A patient presents with dyspnea, fever, a non-productive cough, hypoxemia, and elevated LDH. A CXR shows diffuse, bilateral, symmetrical interstitial infiltrates. Which opportunistic infection is most likely?

<p>Pneumocystis pneumonia (PCP) (A)</p> Signup and view all the answers

For which of the following conditions would prophylactic PO Bactrim (TMP-SMX) typically be prescribed, and at what CD4+ count threshold?

<p>Pneumocystis pneumonia (PCP), CD4+ count &lt; 200 cells/µL (D)</p> Signup and view all the answers

A patient with HIV-associated aspergillosis is most likely to present with which of the following CD4+ counts, and what specific clinical manifestation might also be observed if their CD4 count declines below 250 cells/μL?

<p>CD4+ counts &lt;200 cells/μL; systemic disease (e.g., meningitis) (A)</p> Signup and view all the answers

Which of the following antibiotics is NOT recommended for outpatient treatment of CAP in a patient with no comorbidities?

<p>Ciprofloxacin 500 mg twice daily (B)</p> Signup and view all the answers

Which of the following regimens is appropriate for outpatient treatment of CAP in a patient with comorbidities?

<p>Amoxicillin/clavulanate 875 mg twice daily plus doxycycline 100 mg twice daily (B)</p> Signup and view all the answers

Which antibiotic is the first-line treatment for CAP in children under 5 years old?

<p>High-dose amoxicillin (C)</p> Signup and view all the answers

Which antiviral should be initiated in outpatients presenting with influenza-like illness and pneumonia during influenza season?

<p>Oseltamivir (Tamiflu) (C)</p> Signup and view all the answers

Which of the following treatments reduces the risk of severe COVID-19 or hospitalization in non-hospitalized patients?

<p>Molnupiravir (B)</p> Signup and view all the answers

What is the recommended duration of antibiotic therapy for uncomplicated CAP?

<p>5 days</p> Signup and view all the answers

Which of the following regimens is appropriate for inpatient, non-ICU treatment of CAP?

<p>Ceftriaxone plus azithromycin (A)</p> Signup and view all the answers

Which of the following is indicated for CAP treatment in ICU patients with a penicillin allergy?

<p>Respiratory fluoroquinolone plus aztreonam (D)</p> Signup and view all the answers

Which antibiotic should be added if Pseudomonas is suspected in a patient with CAP?

<p>Piperacillin/tazobactam (B)</p> Signup and view all the answers

Which of the following is recommended for treating pulmonary abscess due to anaerobic bacteria?

<p>Clindamycin (D)</p> Signup and view all the answers

Which of the following pathogens is LEAST likely to cause hospital-acquired pneumonia (HAP)?

<p>Streptococcus pneumoniae (A)</p> Signup and view all the answers

Which of the following combinations is appropriate empiric therapy for HAP in a patient at high risk of mortality?

<p>Piperacillin/tazobactam plus vancomycin and amikacin (C)</p> Signup and view all the answers

Which clinical feature is more suggestive of viral pneumonia compared to bacterial pneumonia?

<p>Diffuse bilateral infiltrates on chest X-ray (D)</p> Signup and view all the answers

Which of the following pathogens is MOST likely to cause atypical pneumonia?

<p>Legionella pneumophila (B)</p> Signup and view all the answers

Which of the following mechanisms primarily leads to hypoxemia in pneumonia?

<p>Ventilation-perfusion (V/Q) mismatch (C)</p> Signup and view all the answers

Which of the following factors is NOT included in the Pneumonia Severity Index (PSI)?

<p>Blood glucose level (B)</p> Signup and view all the answers

Which of the following is NOT a common risk factor for aspiration pneumonia?

<p>History of asthma (A)</p> Signup and view all the answers

Which imaging finding is MOST characteristic of Klebsiella pneumoniae pneumonia?

<p>Cavitary lesions with air-fluid levels (A)</p> Signup and view all the answers

Which chest CT finding is most commonly associated with COVID-19 pneumonia?

<p>Bilateral ground-glass opacities (C)</p> Signup and view all the answers

Which of the following indicates a parapneumonic effusion that requires drainage?

<p>Purulent fluid with positive Gram stain (A)</p> Signup and view all the answers

Which of the following findings is LEAST likely to be associated with pneumonia on physical examination?

<p>Hyperresonance to percussion (A)</p> Signup and view all the answers

Which of the following antibiotics is preferred for treating aspiration pneumonia with suspected anaerobic infection?

<p>Clindamycin (D)</p> Signup and view all the answers

Which of the following characteristics differentiates hospital-acquired pneumonia (HAP) from community-acquired pneumonia (CAP)?

<p>Higher likelihood of multidrug-resistant pathogens (C)</p> Signup and view all the answers

Which of the following laboratory findings is MOST characteristic of Legionella pneumophila infection?

<p>Hyponatremia and elevated liver enzymes (C)</p> Signup and view all the answers

Which of the following factors contributes MOST to the development of ventilator-associated pneumonia (VAP)?

<p>Microaspiration of oropharyngeal secretions (C)</p> Signup and view all the answers

Which of the following scenarios is classified as healthcare-associated pneumonia (HCAP)?

<p>Pneumonia diagnosed in a resident of a long-term care facility (C)</p> Signup and view all the answers

Which of the following fungal pathogens is LEAST likely to cause pneumonia in an immunocompromised patient?

<p>Candida albicans (C)</p> Signup and view all the answers

Which of the following findings is MOST suggestive of Pneumocystis jirovecii pneumonia (PJP) in an HIV-positive patient?

<p>Progressive dyspnea with bilateral ground-glass opacities (C)</p> Signup and view all the answers

Which antibiotic is recommended for treating MRSA pneumonia in hospitalized patients?

<p>Linezolid (B)</p> Signup and view all the answers

Which of the following measures is MOST effective in preventing ventilator-associated pneumonia (VAP)?

<p>Daily sedation interruption and spontaneous breathing trials (C)</p> Signup and view all the answers

Flashcards

Outpatient CAP Treatment (No Comorbidities)

Amoxicillin 1g three times daily, a macrolide, or doxycycline.

Outpatient CAP Treatment (With Comorbidities)

Beta-lactam plus a macrolide or doxycycline, OR a respiratory fluoroquinolone.

CAP treatment for children <5

High-dose amoxicillin.

CAP treatment for children 5-16

Macrolides.

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Antibiotics to AVOID in children

Because they can cause teeth staining and tendon rupture, respectively.

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Treatment during influenza season

Oseltamivir, zanamivir, peramivir, or baloxavir.

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COVID-19 treatment for non-hospitalized patients

Monoclonal antibody bebtelovimab IV.

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Paxlovid & Molnupiravir

Antiviral medications that reduce the risk of COVID-related hospitalization or death in those over 12 with mild-moderate symptoms.

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48-72 Hours

Recommended reevaluation timeframe for patients not responding to CAP therapy.

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Beta-Lactams

Common antibiotic class used in inpatient, non-ICU treatment of community-acquired pneumonia (CAP).

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Anti-pseudomonal beta-lactam

Antibiotic considerations if Pseudomonas is suspected in CAP

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Add vancomycin or linezolid

Antibiotic considerations if CA-MRSA is suspected in CAP

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CXR findings in fungal infections

Increased lung markings, honeycombing, atelectasis, or pleural changes visible on chest X-ray.

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Risk factors for fungal pulmonary infections

More common in immunocompromised patients, such as those with neutropenia, on immunosuppressants, or with HIV.

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Pneumocystis pneumonia (PCP)

Caused by Pneumocystis Jirovecii, presenting with dyspnea, fever, non-productive cough, hypoxemia, and elevated LDH.

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CXR findings in PCP

Diffuse, bilateral, symmetrical interstitial infiltrates (or normal appearance) on chest X-ray.

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PCP Treatment & Prophylaxis

Treat with PO Bactrim (TMZ-SMX). Prophylaxis with PO Bactrim daily for patients with CD4 count < 200 cells/µL.

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When to Stop Antibiotics

Fever should be absent for 48-72 hours and the patient should be stable before stopping antibiotics.

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Pneumococcal Vaccine

Recommended for all high-risk patients.

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Influenza Vaccine

Recommended annually for all patients and healthcare workers at high risk.

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Risk Factors for Lung Abscess

Often seen in patients with altered consciousness (e.g., alcoholism) and periodontal disease.

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Necrotizing Pneumonia Causes

S. aureus, K. pneumoniae, and other gram-negative bacilli can cause necrotizing pneumonias leading to lung abscesses.

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Bronchial Obstruction & Abscess

Tumors, foreign bodies, or bronchial stenosis can obstruct airways, leading to lung abscess.

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Antibiotic Coverage for Lung Abscess

Beta-lactam/beta-lactamase inhibitor or clindamycin.

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Bronchiectasis

Acquired disease causing abnormal and permanent dilation of the bronchi, leading to secretion pooling and recurrent infections. Often from neglected infections.

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Ciprofloxacin in CAP

An antibiotic not typically recommended for outpatient CAP due to inadequate Streptococcus pneumoniae coverage.

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CAP Treatment with comorbidities

A beta-lactam (like amoxicillin/clavulanate) plus a macrolide or doxycycline, or a respiratory fluoroquinolone.

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High-dose amoxicillin (Pediatrics)

Preferred antibiotic for CAP in children under 5 years old because it is effective against Streptococcus pneumoniae.

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Oseltamivir (Tamiflu)

Antiviral commonly used to reduce the severity and duration of influenza-associated pneumonia.

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Molnupiravir

An antiviral authorized to reduce COVID-19-related hospitalization and death, especially when started early.

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CAP Treatment Duration

The minimum recommended duration of antibiotic therapy for uncomplicated CAP, assuming the patient is afebrile for 48-72 hours.

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Ceftriaxone

A drug used for beta-lactam coverage for inpatient, non-ICU CAP treatment.

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Respiratory fluoroquinolone plus aztreonam

A treatment for penicillin-allergic ICU patients with CAP.

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Piperacillin/tazobactam

An antibiotic to add when Pseudomonas is suspected in a patient with CAP.

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Clindamycin

An antibiotic recommended for treating pulmonary abscesses due to anaerobic bacteria.

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Streptococcus pneumoniae in HAP

Pathogen LEAST likely to cause hospital-acquired pneumonia (HAP).

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Piperacillin/tazobactam, vancomycin, and amikacin

An appropriate empiric therapy for HAP in a patient at high risk of mortality, covering Pseudomonas and MRSA.

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Diffuse bilateral infiltrates on chest X-ray

A clinical feature more suggestive of viral pneumonia compared to bacterial pneumonia.

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Legionella pneumophila

A pathogen most likely to cause atypical pneumonia.

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Ventilation-perfusion (V/Q) mismatch

The primary mechanism leading to hypoxemia in pneumonia.

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Blood glucose level (PSI)

A factor NOT included in the Pneumonia Severity Index (PSI).

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History of asthma (Aspiration)

A risk factor NOT commonly associated with aspiration pneumonia.

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Cavitary lesions with air-fluid levels

Imaging finding most characteristic of Klebsiella pneumoniae pneumonia.

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Bilateral ground-glass opacities (COVID-19)

A chest CT finding most commonly associated with COVID-19 pneumonia.

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Purulent fluid with positive Gram stain

Indication of a parapneumonic effusion that requires drainage.

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Hyperresonance to percussion

A physical exam finding LEAST likely to be associated with pneumonia.

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Clindamycin (Aspiration Pneumonia)

Preferred antibiotic for treating aspiration pneumonia with suspected anaerobic infection.

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Higher likelihood of multidrug-resistant pathogens

Characteristic that differentiates hospital-acquired pneumonia (HAP) from community-acquired pneumonia (CAP).

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Hyponatremia and elevated liver enzymes (Legionella)

Laboratory finding most characteristic of Legionella pneumophila infection.

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Microaspiration of oropharyngeal secretions

Factor that contributes MOST to the development of ventilator-associated pneumonia (VAP).

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Pneumonia diagnosed in a resident of a long-term care facility

Scenario classified as healthcare-associated pneumonia (HCAP).

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Candida albicans (Pneumonia)

Fungal pathogen LEAST likely to cause pneumonia in an immunocompromised patient.

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Progressive dyspnea with bilateral ground-glass opacities

Finding MOST suggestive of Pneumocystis jirovecii pneumonia (PJP) in an HIV-positive patient

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CAP Patient Afebrile

Duration of antibiotic after patient becomes afebrile.

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Diagnosing Pulmonary Aspergillosis

Pulmonary aspergillosis is a lung infection caused by Aspergillus, a common mold.

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Study Notes

  • Ciprofoxacin doesn't have enough coverage of Streptococcus pneumoniae, respiratory fluoroquinolones like levofloxacin or moxifloxacin should be used instead.
  • Patients with comorbidities require a beta-lactam like amoxicillin/clavulanate plus a macrolide or doxycycline, or a respiratory fluoroquinolone for CAP.
  • High-dose amoxicillin is preferred for children under 5 due to its effectiveness against Streptococcus pneumoniae.
  • Macrolides are preferred for children aged 5-16 to cover atypical pathogens.
  • Oseltamivir is commonly used to reduce the severity and duration of influenza-associated pneumonia when initiated early.
  • Molnupiravir, along with Paxlovid (nirmatrelvir/ritonavir), is authorized to reduce COVID-19-related hospitalization and death, especially when started within 5 days of symptom onset.
  • Uncomplicated CAP should be treated for at least 5 days, provided the patient is afebrile for 48-72 hours and clinically stable.
  • Non-ICU CAP treatment typically includes a beta-lactam (e.g., ceftriaxone) plus a macrolide (e.g., azithromycin) or a respiratory fluoroquinolone.
  • For ICU patients with a penicillin allergy, a respiratory fluoroquinolone (e.g., levofloxacin or moxifloxacin) plus aztreonam is recommended for CAP.
  • Anti-pseudomonal beta-lactams such as piperacillin/tazobactam are essential when Pseudomonas is suspected.
  • Anaerobic pulmonary abscesses are treated with antibiotics like clindamycin or beta-lactam/beta-lactamase inhibitors.
  • Streptococcus pneumoniae is a common cause of community-acquired pneumonia (CAP), not HAP.
  • Hospital Acquired Pneumonia (HAP) is more commonly caused by multidrug-resistant organisms such as Pseudomonas, MRSA, and Klebsiella.
  • High-risk HAP requires coverage for Pseudomonas and MRSA. This regimen includes an anti-pseudomonal beta-lactam (piperacillin/tazobactam), vancomycin for MRSA, and amikacin for additional Gram-negative coverage.
  • Viral pneumonia often presents with diffuse bilateral infiltrates, while bacterial pneumonia typically shows localized consolidation.
  • Atypical pneumonia is caused by pathogens such as Legionella, Mycoplasma pneumoniae, and Chlamydophila pneumoniae, all of which do not respond to beta-lactams.
  • Inflammatory exudate in alveoli impairs gas exchange, leading to areas of low ventilation with preserved perfusion, causing hypoxemia.
  • The Pneumonia Severity Index (PSI) assesses pneumonia severity using factors such as age, blood pressure, oxygenation, and comorbidities, but blood glucose is not included.
  • Asthma is unrelated to aspiration pneumonia, which is more common in patients with impaired swallowing, altered consciousness, or GERD.
  • Klebsiella pneumoniae often causes necrotizing pneumonia with cavitation and air-fluid levels, particularly in alcoholics and immunocompromised patients.
  • COVID-19 pneumonia typically presents with bilateral ground-glass opacities, often with peripheral and subpleural distribution.
  • Empyema (purulent pleural effusion) requires drainage, especially if fluid is infected or has low pH, low glucose, and high lactate dehydrogenase (LDH).
  • Hyperresonance is more typical of pneumothorax or emphysema. Pneumonia typically presents with dullness to percussion due to alveolar consolidation.
  • Clindamycin is preferred for aspiration pneumonia due to its effectiveness against anaerobes commonly found in oropharyngeal flora.
  • HAP is more likely to involve multidrug-resistant pathogens like Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA) compared to CAP.
  • Legionella pneumophila often causes hyponatremia and elevated liver enzymes, which help differentiate it from other causes of pneumonia.
  • Ventilator Associated Pneumonia (VAP) commonly results from microaspiration of contaminated secretions, leading to infection in mechanically ventilated patients.
  • Healthcare-associated pneumonia (HCAP) refers to pneumonia acquired outside the hospital in individuals with healthcare exposure, such as nursing home residents.
  • Candida albicans rarely causes pneumonia, even in immunocompromised individuals, unlike Pneumocystis, Histoplasma, and Cryptococcus.
  • Pneumocystis jirovecii Pneumonia (PJP) typically presents with progressive dyspnea, nonproductive cough, and bilateral ground-glass opacities on chest imaging, especially in HIV-positive patients with CD4 <200 cells/μL.
  • Linezolid is effective against MRSA pneumonia, particularly in hospitalized patients. Vancomycin is an alternative option.
  • Daily sedation breaks and spontaneous breathing trials reduce ventilator duration and decrease the risk of VAP.

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Description

This quiz focuses on treatment options for pneumonia, covering criteria for prescribing antivirals, initial treatment approaches for community-acquired pneumonia (CAP). It also covers antibiotic choices for patients with penicillin allergies and duration of antibiotic treatment.

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