Podcast
Questions and Answers
Which of the following is NOT a criterion for prescribing Paxlovid or Molnupiravir?
Which of the following is NOT a criterion for prescribing Paxlovid or Molnupiravir?
- Patient has severe COVID-19 symptoms. (correct)
- Treatment can be started within 5 days of symptom onset.
- Patient is at risk for severe illness.
- Patient is over the age of 12.
A patient is admitted to the non-ICU setting with community-acquired pneumonia (CAP). Initial treatment options include all EXCEPT which of the following?
A patient is admitted to the non-ICU setting with community-acquired pneumonia (CAP). Initial treatment options include all EXCEPT which of the following?
- Respiratory fluoroquinolone
- Vancomycin monotherapy (correct)
- Beta-lactam plus doxycycline
- Beta-lactam plus a macrolide
A patient with a known penicillin allergy requires inpatient treatment for community-acquired pneumonia (CAP) in the ICU. Which of the following antibiotic regimens is most appropriate?
A patient with a known penicillin allergy requires inpatient treatment for community-acquired pneumonia (CAP) in the ICU. Which of the following antibiotic regimens is most appropriate?
- Piperacillin/tazobactam plus vancomycin
- Ceftriaxone plus azithromycin
- Ampicillin/sulbactam plus doxycycline
- Aztreonam plus a respiratory fluoroquinolone (correct)
Which beta-lactam antibiotic provides Pseudomonas coverage?
Which beta-lactam antibiotic provides Pseudomonas coverage?
A patient is being treated for community-acquired pneumonia and is not responding to initial antibiotic therapy after 60 hours. What is the most appropriate next step in management?
A patient is being treated for community-acquired pneumonia and is not responding to initial antibiotic therapy after 60 hours. What is the most appropriate next step in management?
For uncomplicated pneumonia patients, what is the typical duration of antibiotic treatment, assuming they respond well to the therapy?
For uncomplicated pneumonia patients, what is the typical duration of antibiotic treatment, assuming they respond well to the therapy?
Which antibiotic regimen is most appropriate for an adult outpatient with community-acquired pneumonia (CAP) and no comorbidities or risk factors for drug-resistant Streptococcus pneumoniae?
Which antibiotic regimen is most appropriate for an adult outpatient with community-acquired pneumonia (CAP) and no comorbidities or risk factors for drug-resistant Streptococcus pneumoniae?
Before discontinuing antibiotic therapy for pneumonia, a patient should be afebrile for how long?
Before discontinuing antibiotic therapy for pneumonia, a patient should be afebrile for how long?
Which of the following is a recommended preventative measure for high-risk pneumonia patients?
Which of the following is a recommended preventative measure for high-risk pneumonia patients?
An adult outpatient presents with CAP and has a history of antimicrobial use within the past 90 days. Which empiric treatment would be most appropriate?
An adult outpatient presents with CAP and has a history of antimicrobial use within the past 90 days. Which empiric treatment would be most appropriate?
What is the recommended first-line antibiotic agent for children under 5 years old with uncomplicated community-acquired pneumonia?
What is the recommended first-line antibiotic agent for children under 5 years old with uncomplicated community-acquired pneumonia?
Which of the following is the most common microbiological finding in lung abscesses?
Which of the following is the most common microbiological finding in lung abscesses?
A patient with a history of alcoholism is diagnosed with a lung abscess. Which of the following contributing factors is most likely associated with this condition?
A patient with a history of alcoholism is diagnosed with a lung abscess. Which of the following contributing factors is most likely associated with this condition?
In children aged 5-16 years with community-acquired pneumonia, which class of antibiotics is typically preferred to cover atypical pathogens like Mycoplasma pneumoniae?
In children aged 5-16 years with community-acquired pneumonia, which class of antibiotics is typically preferred to cover atypical pathogens like Mycoplasma pneumoniae?
Which of the following antibiotic classes is typically used to treat lung abscesses to ensure coverage against anaerobic bacteria?
Which of the following antibiotic classes is typically used to treat lung abscesses to ensure coverage against anaerobic bacteria?
Why are tetracyclines and fluoroquinolones generally avoided in pediatric patients with community-acquired pneumonia?
Why are tetracyclines and fluoroquinolones generally avoided in pediatric patients with community-acquired pneumonia?
During influenza season, which antiviral medication is LEAST likely to be considered as an initial treatment for an outpatient presenting with pneumonia and flu-like symptoms?
During influenza season, which antiviral medication is LEAST likely to be considered as an initial treatment for an outpatient presenting with pneumonia and flu-like symptoms?
What is the primary mechanism by which cystic fibrosis leads to bronchiectasis?
What is the primary mechanism by which cystic fibrosis leads to bronchiectasis?
A patient with bronchiectasis presents with hemoptysis and recurrent lower respiratory tract infections. Bronchiectasis results in abnormal and permanent dilation of the bronchi. Which of the following mechanisms is least likely to contribute directly to the pathogenesis of bronchiectasis?
A patient with bronchiectasis presents with hemoptysis and recurrent lower respiratory tract infections. Bronchiectasis results in abnormal and permanent dilation of the bronchi. Which of the following mechanisms is least likely to contribute directly to the pathogenesis of bronchiectasis?
A non-hospitalized patient tests positive for COVID-19 and is at high risk for severe disease. Which treatment option directly targets the virus to reduce the risk of hospitalization?
A non-hospitalized patient tests positive for COVID-19 and is at high risk for severe disease. Which treatment option directly targets the virus to reduce the risk of hospitalization?
A previously healthy 6-year-old child presents with a 2-day history of fever, cough, and mild shortness of breath. Auscultation reveals decreased breath sounds in the left lower lobe. The child is up-to-date on all vaccinations. Considering the likely causative organisms and current guidelines, what is an appropriate empiric treatment approach?
A previously healthy 6-year-old child presents with a 2-day history of fever, cough, and mild shortness of breath. Auscultation reveals decreased breath sounds in the left lower lobe. The child is up-to-date on all vaccinations. Considering the likely causative organisms and current guidelines, what is an appropriate empiric treatment approach?
Which of the following radiographic findings might be observed on a chest X-ray (CXR) of a patient with a pulmonary fungal infection?
Which of the following radiographic findings might be observed on a chest X-ray (CXR) of a patient with a pulmonary fungal infection?
In which patient population are fungal pulmonary infections most commonly observed?
In which patient population are fungal pulmonary infections most commonly observed?
A patient presents with dyspnea, fever, a non-productive cough, hypoxemia, and elevated LDH. A CXR shows diffuse, bilateral, symmetrical interstitial infiltrates. Which opportunistic infection is most likely?
A patient presents with dyspnea, fever, a non-productive cough, hypoxemia, and elevated LDH. A CXR shows diffuse, bilateral, symmetrical interstitial infiltrates. Which opportunistic infection is most likely?
For which of the following conditions would prophylactic PO Bactrim (TMP-SMX) typically be prescribed, and at what CD4+ count threshold?
For which of the following conditions would prophylactic PO Bactrim (TMP-SMX) typically be prescribed, and at what CD4+ count threshold?
A patient with HIV-associated aspergillosis is most likely to present with which of the following CD4+ counts, and what specific clinical manifestation might also be observed if their CD4 count declines below 250 cells/μL?
A patient with HIV-associated aspergillosis is most likely to present with which of the following CD4+ counts, and what specific clinical manifestation might also be observed if their CD4 count declines below 250 cells/μL?
Which of the following antibiotics is NOT recommended for outpatient treatment of CAP in a patient with no comorbidities?
Which of the following antibiotics is NOT recommended for outpatient treatment of CAP in a patient with no comorbidities?
Which of the following regimens is appropriate for outpatient treatment of CAP in a patient with comorbidities?
Which of the following regimens is appropriate for outpatient treatment of CAP in a patient with comorbidities?
Which antibiotic is the first-line treatment for CAP in children under 5 years old?
Which antibiotic is the first-line treatment for CAP in children under 5 years old?
Which antiviral should be initiated in outpatients presenting with influenza-like illness and pneumonia during influenza season?
Which antiviral should be initiated in outpatients presenting with influenza-like illness and pneumonia during influenza season?
Which of the following treatments reduces the risk of severe COVID-19 or hospitalization in non-hospitalized patients?
Which of the following treatments reduces the risk of severe COVID-19 or hospitalization in non-hospitalized patients?
What is the recommended duration of antibiotic therapy for uncomplicated CAP?
What is the recommended duration of antibiotic therapy for uncomplicated CAP?
Which of the following regimens is appropriate for inpatient, non-ICU treatment of CAP?
Which of the following regimens is appropriate for inpatient, non-ICU treatment of CAP?
Which of the following is indicated for CAP treatment in ICU patients with a penicillin allergy?
Which of the following is indicated for CAP treatment in ICU patients with a penicillin allergy?
Which antibiotic should be added if Pseudomonas is suspected in a patient with CAP?
Which antibiotic should be added if Pseudomonas is suspected in a patient with CAP?
Which of the following is recommended for treating pulmonary abscess due to anaerobic bacteria?
Which of the following is recommended for treating pulmonary abscess due to anaerobic bacteria?
Which of the following pathogens is LEAST likely to cause hospital-acquired pneumonia (HAP)?
Which of the following pathogens is LEAST likely to cause hospital-acquired pneumonia (HAP)?
Which of the following combinations is appropriate empiric therapy for HAP in a patient at high risk of mortality?
Which of the following combinations is appropriate empiric therapy for HAP in a patient at high risk of mortality?
Which clinical feature is more suggestive of viral pneumonia compared to bacterial pneumonia?
Which clinical feature is more suggestive of viral pneumonia compared to bacterial pneumonia?
Which of the following pathogens is MOST likely to cause atypical pneumonia?
Which of the following pathogens is MOST likely to cause atypical pneumonia?
Which of the following mechanisms primarily leads to hypoxemia in pneumonia?
Which of the following mechanisms primarily leads to hypoxemia in pneumonia?
Which of the following factors is NOT included in the Pneumonia Severity Index (PSI)?
Which of the following factors is NOT included in the Pneumonia Severity Index (PSI)?
Which of the following is NOT a common risk factor for aspiration pneumonia?
Which of the following is NOT a common risk factor for aspiration pneumonia?
Which imaging finding is MOST characteristic of Klebsiella pneumoniae pneumonia?
Which imaging finding is MOST characteristic of Klebsiella pneumoniae pneumonia?
Which chest CT finding is most commonly associated with COVID-19 pneumonia?
Which chest CT finding is most commonly associated with COVID-19 pneumonia?
Which of the following indicates a parapneumonic effusion that requires drainage?
Which of the following indicates a parapneumonic effusion that requires drainage?
Which of the following findings is LEAST likely to be associated with pneumonia on physical examination?
Which of the following findings is LEAST likely to be associated with pneumonia on physical examination?
Which of the following antibiotics is preferred for treating aspiration pneumonia with suspected anaerobic infection?
Which of the following antibiotics is preferred for treating aspiration pneumonia with suspected anaerobic infection?
Which of the following characteristics differentiates hospital-acquired pneumonia (HAP) from community-acquired pneumonia (CAP)?
Which of the following characteristics differentiates hospital-acquired pneumonia (HAP) from community-acquired pneumonia (CAP)?
Which of the following laboratory findings is MOST characteristic of Legionella pneumophila infection?
Which of the following laboratory findings is MOST characteristic of Legionella pneumophila infection?
Which of the following factors contributes MOST to the development of ventilator-associated pneumonia (VAP)?
Which of the following factors contributes MOST to the development of ventilator-associated pneumonia (VAP)?
Which of the following scenarios is classified as healthcare-associated pneumonia (HCAP)?
Which of the following scenarios is classified as healthcare-associated pneumonia (HCAP)?
Which of the following fungal pathogens is LEAST likely to cause pneumonia in an immunocompromised patient?
Which of the following fungal pathogens is LEAST likely to cause pneumonia in an immunocompromised patient?
Which of the following findings is MOST suggestive of Pneumocystis jirovecii pneumonia (PJP) in an HIV-positive patient?
Which of the following findings is MOST suggestive of Pneumocystis jirovecii pneumonia (PJP) in an HIV-positive patient?
Which antibiotic is recommended for treating MRSA pneumonia in hospitalized patients?
Which antibiotic is recommended for treating MRSA pneumonia in hospitalized patients?
Which of the following measures is MOST effective in preventing ventilator-associated pneumonia (VAP)?
Which of the following measures is MOST effective in preventing ventilator-associated pneumonia (VAP)?
Flashcards
Outpatient CAP Treatment (No Comorbidities)
Outpatient CAP Treatment (No Comorbidities)
Amoxicillin 1g three times daily, a macrolide, or doxycycline.
Outpatient CAP Treatment (With Comorbidities)
Outpatient CAP Treatment (With Comorbidities)
Beta-lactam plus a macrolide or doxycycline, OR a respiratory fluoroquinolone.
CAP treatment for children <5
CAP treatment for children <5
High-dose amoxicillin.
CAP treatment for children 5-16
CAP treatment for children 5-16
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Antibiotics to AVOID in children
Antibiotics to AVOID in children
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Treatment during influenza season
Treatment during influenza season
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COVID-19 treatment for non-hospitalized patients
COVID-19 treatment for non-hospitalized patients
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Paxlovid & Molnupiravir
Paxlovid & Molnupiravir
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48-72 Hours
48-72 Hours
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Beta-Lactams
Beta-Lactams
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Anti-pseudomonal beta-lactam
Anti-pseudomonal beta-lactam
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Add vancomycin or linezolid
Add vancomycin or linezolid
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CXR findings in fungal infections
CXR findings in fungal infections
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Risk factors for fungal pulmonary infections
Risk factors for fungal pulmonary infections
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Pneumocystis pneumonia (PCP)
Pneumocystis pneumonia (PCP)
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CXR findings in PCP
CXR findings in PCP
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PCP Treatment & Prophylaxis
PCP Treatment & Prophylaxis
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When to Stop Antibiotics
When to Stop Antibiotics
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Pneumococcal Vaccine
Pneumococcal Vaccine
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Influenza Vaccine
Influenza Vaccine
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Risk Factors for Lung Abscess
Risk Factors for Lung Abscess
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Necrotizing Pneumonia Causes
Necrotizing Pneumonia Causes
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Bronchial Obstruction & Abscess
Bronchial Obstruction & Abscess
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Antibiotic Coverage for Lung Abscess
Antibiotic Coverage for Lung Abscess
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Bronchiectasis
Bronchiectasis
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Ciprofloxacin in CAP
Ciprofloxacin in CAP
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CAP Treatment with comorbidities
CAP Treatment with comorbidities
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High-dose amoxicillin (Pediatrics)
High-dose amoxicillin (Pediatrics)
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Oseltamivir (Tamiflu)
Oseltamivir (Tamiflu)
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Molnupiravir
Molnupiravir
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CAP Treatment Duration
CAP Treatment Duration
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Ceftriaxone
Ceftriaxone
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Respiratory fluoroquinolone plus aztreonam
Respiratory fluoroquinolone plus aztreonam
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Piperacillin/tazobactam
Piperacillin/tazobactam
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Clindamycin
Clindamycin
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Streptococcus pneumoniae in HAP
Streptococcus pneumoniae in HAP
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Piperacillin/tazobactam, vancomycin, and amikacin
Piperacillin/tazobactam, vancomycin, and amikacin
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Diffuse bilateral infiltrates on chest X-ray
Diffuse bilateral infiltrates on chest X-ray
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Legionella pneumophila
Legionella pneumophila
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Ventilation-perfusion (V/Q) mismatch
Ventilation-perfusion (V/Q) mismatch
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Blood glucose level (PSI)
Blood glucose level (PSI)
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History of asthma (Aspiration)
History of asthma (Aspiration)
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Cavitary lesions with air-fluid levels
Cavitary lesions with air-fluid levels
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Bilateral ground-glass opacities (COVID-19)
Bilateral ground-glass opacities (COVID-19)
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Purulent fluid with positive Gram stain
Purulent fluid with positive Gram stain
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Hyperresonance to percussion
Hyperresonance to percussion
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Clindamycin (Aspiration Pneumonia)
Clindamycin (Aspiration Pneumonia)
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Higher likelihood of multidrug-resistant pathogens
Higher likelihood of multidrug-resistant pathogens
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Hyponatremia and elevated liver enzymes (Legionella)
Hyponatremia and elevated liver enzymes (Legionella)
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Microaspiration of oropharyngeal secretions
Microaspiration of oropharyngeal secretions
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Pneumonia diagnosed in a resident of a long-term care facility
Pneumonia diagnosed in a resident of a long-term care facility
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Candida albicans (Pneumonia)
Candida albicans (Pneumonia)
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Progressive dyspnea with bilateral ground-glass opacities
Progressive dyspnea with bilateral ground-glass opacities
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CAP Patient Afebrile
CAP Patient Afebrile
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Diagnosing Pulmonary Aspergillosis
Diagnosing Pulmonary Aspergillosis
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Study Notes
- Ciprofoxacin doesn't have enough coverage of Streptococcus pneumoniae, respiratory fluoroquinolones like levofloxacin or moxifloxacin should be used instead.
- Patients with comorbidities require a beta-lactam like amoxicillin/clavulanate plus a macrolide or doxycycline, or a respiratory fluoroquinolone for CAP.
- High-dose amoxicillin is preferred for children under 5 due to its effectiveness against Streptococcus pneumoniae.
- Macrolides are preferred for children aged 5-16 to cover atypical pathogens.
- Oseltamivir is commonly used to reduce the severity and duration of influenza-associated pneumonia when initiated early.
- Molnupiravir, along with Paxlovid (nirmatrelvir/ritonavir), is authorized to reduce COVID-19-related hospitalization and death, especially when started within 5 days of symptom onset.
- Uncomplicated CAP should be treated for at least 5 days, provided the patient is afebrile for 48-72 hours and clinically stable.
- Non-ICU CAP treatment typically includes a beta-lactam (e.g., ceftriaxone) plus a macrolide (e.g., azithromycin) or a respiratory fluoroquinolone.
- For ICU patients with a penicillin allergy, a respiratory fluoroquinolone (e.g., levofloxacin or moxifloxacin) plus aztreonam is recommended for CAP.
- Anti-pseudomonal beta-lactams such as piperacillin/tazobactam are essential when Pseudomonas is suspected.
- Anaerobic pulmonary abscesses are treated with antibiotics like clindamycin or beta-lactam/beta-lactamase inhibitors.
- Streptococcus pneumoniae is a common cause of community-acquired pneumonia (CAP), not HAP.
- Hospital Acquired Pneumonia (HAP) is more commonly caused by multidrug-resistant organisms such as Pseudomonas, MRSA, and Klebsiella.
- High-risk HAP requires coverage for Pseudomonas and MRSA. This regimen includes an anti-pseudomonal beta-lactam (piperacillin/tazobactam), vancomycin for MRSA, and amikacin for additional Gram-negative coverage.
- Viral pneumonia often presents with diffuse bilateral infiltrates, while bacterial pneumonia typically shows localized consolidation.
- Atypical pneumonia is caused by pathogens such as Legionella, Mycoplasma pneumoniae, and Chlamydophila pneumoniae, all of which do not respond to beta-lactams.
- Inflammatory exudate in alveoli impairs gas exchange, leading to areas of low ventilation with preserved perfusion, causing hypoxemia.
- The Pneumonia Severity Index (PSI) assesses pneumonia severity using factors such as age, blood pressure, oxygenation, and comorbidities, but blood glucose is not included.
- Asthma is unrelated to aspiration pneumonia, which is more common in patients with impaired swallowing, altered consciousness, or GERD.
- Klebsiella pneumoniae often causes necrotizing pneumonia with cavitation and air-fluid levels, particularly in alcoholics and immunocompromised patients.
- COVID-19 pneumonia typically presents with bilateral ground-glass opacities, often with peripheral and subpleural distribution.
- Empyema (purulent pleural effusion) requires drainage, especially if fluid is infected or has low pH, low glucose, and high lactate dehydrogenase (LDH).
- Hyperresonance is more typical of pneumothorax or emphysema. Pneumonia typically presents with dullness to percussion due to alveolar consolidation.
- Clindamycin is preferred for aspiration pneumonia due to its effectiveness against anaerobes commonly found in oropharyngeal flora.
- HAP is more likely to involve multidrug-resistant pathogens like Pseudomonas aeruginosa and Methicillin-resistant Staphylococcus aureus (MRSA) compared to CAP.
- Legionella pneumophila often causes hyponatremia and elevated liver enzymes, which help differentiate it from other causes of pneumonia.
- Ventilator Associated Pneumonia (VAP) commonly results from microaspiration of contaminated secretions, leading to infection in mechanically ventilated patients.
- Healthcare-associated pneumonia (HCAP) refers to pneumonia acquired outside the hospital in individuals with healthcare exposure, such as nursing home residents.
- Candida albicans rarely causes pneumonia, even in immunocompromised individuals, unlike Pneumocystis, Histoplasma, and Cryptococcus.
- Pneumocystis jirovecii Pneumonia (PJP) typically presents with progressive dyspnea, nonproductive cough, and bilateral ground-glass opacities on chest imaging, especially in HIV-positive patients with CD4 <200 cells/μL.
- Linezolid is effective against MRSA pneumonia, particularly in hospitalized patients. Vancomycin is an alternative option.
- Daily sedation breaks and spontaneous breathing trials reduce ventilator duration and decrease the risk of VAP.
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Description
This quiz focuses on treatment options for pneumonia, covering criteria for prescribing antivirals, initial treatment approaches for community-acquired pneumonia (CAP). It also covers antibiotic choices for patients with penicillin allergies and duration of antibiotic treatment.