Plummer-Vinson Syndrome (PVS)

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Questions and Answers

What is the primary characteristic of Plummer-Vinson syndrome?

  • Vitamin B12 deficiency causing neurological symptoms
  • Difficulty swallowing and iron deficiency anemia (correct)
  • Folate deficiency leading to megaloblastic anemia
  • Excessive production of red blood cells

Which of the following is NOT a common physical finding associated with iron deficiency?

  • Weakness, fatigue, and shortness of breath
  • Yellowing of the skin and eyes (jaundice) (correct)
  • Spoon-shaped nails (koilonychia)
  • Shiny red tongue due to atrophy of lingual papillae

What is the primary treatment for Plummer-Vinson syndrome?

  • Erythropoietin injections
  • Filgrastim (granulocyte colony-stimulating factor)
  • Vitamin B12 and folate supplementation
  • Iron supplementation (correct)

Which of the following statements about Plummer-Vinson syndrome is correct?

<p>It is a rare disease involving difficulty swallowing and iron deficiency anemia. (B)</p> Signup and view all the answers

Which of the following vitamins or minerals is NOT directly involved in the pathogenesis or treatment of Plummer-Vinson syndrome?

<p>Erythropoietin (B)</p> Signup and view all the answers

Which of the following statements about Plummer-Vinson syndrome is FALSE?

<p>It is caused by a deficiency in vitamin B12 and folate. (D)</p> Signup and view all the answers

What characteristic of the myeloblasts is described in the passage?

<p>They have coarse rod-shaped intracytoplasmic granules. (B)</p> Signup and view all the answers

What do Auer rods indicate about the myeloblasts?

<p>They indicate myeloid differentiation. (D)</p> Signup and view all the answers

What is the primary cause of the clinical manifestations of acute myelogenous leukemia (AML) described in the passage?

<p>All of the above. (D)</p> Signup and view all the answers

Which of the following is a marker of immature lymphocytes in acute lymphoblastic leukemia (ALL)?

<p>Terminal deoxynucleotidyl transferase (TdT) (A)</p> Signup and view all the answers

Which of the following is a characteristic of hairy cell leukemia?

<p>Positive for tartrate resistant acid phosphatase (TRAP) (A)</p> Signup and view all the answers

What is the primary cell type affected in hairy cell leukemia?

<p>B-lymphocyte precursors (D)</p> Signup and view all the answers

Which of the following is a common clinical presentation of hairy cell leukemia?

<p>Splenomegaly, fatigue, and pancytopenia (C)</p> Signup and view all the answers

What is the primary function of major basic protein found in eosinophil granules?

<p>It helps defend against parasites. (A)</p> Signup and view all the answers

Which of the following statements about acute lymphoblastic leukemia (ALL) is correct?

<p>It is characterized by the presence of terminal deoxynucleotidyl transferase (TdT) in the neoplastic cells. (B)</p> Signup and view all the answers

What is the primary cell type affected in acute myelogenous leukemia (AML)?

<p>Myeloid precursors (A)</p> Signup and view all the answers

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