PLGA Nanoparticles and Alginate in Drug Delivery

The Freundlich-Ostwald equation is used to calculate the dissolution pressure.

Amoxicillin is an example of a poorly soluble drug with a dissolution time greater than GI transit time.

Lyophilization is used to improve the re-dispersibility of solid dosage forms.

Nanoparticles are used for targeted delivery with a longer time frame.

Lipid-based mRNA delivery systems are a recent example of nanodelivery for vaccination.

Ciprofloxacin is an example of a poorly soluble drug with a dissolution time greater than GI transit time.

Albumin-PTX-complex binds to SPLARC, which is overexpressed in many tumors.

Abraxane has a higher Cmax than Taxol.

Abraxane and Taxol have the same AUC.

The typically applied dose for Abraxane is 260 mg/m², which is better tolerated by patients.

One of the methods used to produce nanoparticles is high-pressure homogenization.

The problems to be addressed in nanoparticle production are low drug solubility and fast dissolution.

PLGA nanoparticles and alginate have good solubility and permeability for drug delivery.

Drug delivery techniques primarily focus on improving the aesthetic appearance of pharmaceuticals.

Nanomedicine is a field that combines nanotechnology with medicine to develop targeted and personalized treatments.

The article by Zhang et al. in ACS Nano in 2012 has the DOI number 175, 713.

The circulation time of cGNPs in blood is primarily determined by membrane properties.

Nano, in the context of nanomedicine, means a factor of 10 to the power of -12.

Nanomedicine is primarily used for cosmetic applications in medicine.

The force spectroscopy results indicate a Fmax baseline of 0 adhesion piezo extension.

Regulatory aspects are crucial in nanomedicine to maintain quality, safety, and efficacy.

The preparation of gelatin solution involves the use of crosslinking for defined times.

Young's modulus increases linearly with crosslinking time, with a correlation coefficient r² = 0.98692.

Loading a drug into the matrix impacts the Young's modulus if the drug is crosslinked.

Nanomedicine is defined as the application of 'nano' particles in medicine.

According to the EU cosmetics guideline, a nanomaterial is insoluble or biologically persistent.

The EU (EG) Nr 1223/2009 guideline defines a particle as any piece of matter without defined physical boundaries.

An agglomerate is a strongly bound or fused particle, according to EU (2011) Commission Recommendation.

The Commission Recommendation of 18 October 2011 defines a nanomaterial as containing particles between 1-100 nm.

The document mentions the application of 'nano' in areas other than medicine.