Pleuromutilins

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Questions and Answers

What is the ranking of Pleuromutilins in the WHO list of medically important microbial?

Important antimicrobials

What is a key characteristic of pleuromutilin molecules/chemistry/formulations?

They are lipophilic weak organic bases

What is a key characteristic of pleuromutilins in terms of absorption?

  • High oral bioavailability in monogastric animals but inactivated by ruminal flora (correct)
  • Rapid metabolism in the stomach, leading to low bioavailability
  • Poor absorption, requiring IV administration
  • Complete absorption in both ruminants and monogastric species

How are pleuromutilins distributed in the body?

<p>They are widely distributed in most tissues and intracellularly (B)</p> Signup and view all the answers

What is a notable characteristic of pleuromutilins regarding metabolism and elimination?

<p>They are metabolized rapidly, leading to a short half-life (B)</p> Signup and view all the answers

What is an important drug interaction concern with pleuromutilins?

<p>They interact with ionophores, potentially leading to toxicity (A)</p> Signup and view all the answers

What is the mechanism of action of pleuromutilins?

<p>Inhibition of the 50S ribosomal subunit, preventing protein synthesis (C)</p> Signup and view all the answers

What is the spectrum of activity for Pleuromutilins?

<p>Broad spectrum</p> Signup and view all the answers

How does the spectrum of pleuromutilins compare to macrolides?

<p>They are more effective against Mycoplasma and anaerobes than macrolides (B)</p> Signup and view all the answers

How quickly does bacterial resistance develop against pleuromutilins?

<p>Rapidly, with repeated exposure (B)</p> Signup and view all the answers

What is a reported adverse effect of tiamulin in swine?

<p>Dermatitis (A)</p> Signup and view all the answers

How are pleuromutilins primarily administered in veterinary medicine?

<p>Orally for swine (B)</p> Signup and view all the answers

Why is the use of pleuromutilins as growth promoters not considered a rational use?

<p>It increases bacterial resistance, reducing long-term effectiveness (B)</p> Signup and view all the answers

Which condition in swine is commonly treated with pleuromutilins?

<p>Respiratory diseases caused by Mycoplasma hyopneumoniae (A)</p> Signup and view all the answers

The clinical use of Pleuromutilins in swine for growth promotion is deemed an irrational use

<p>True (A)</p> Signup and view all the answers

Flashcards

Pleuromutilins WHO ranking

Important antimicrobials

Pleuromutilin Chemistry

Lipophilic weak organic bases.

Pleuromutilin Absorption

High oral bioavailability in monogastric animals but inactivated by ruminal flora.

Pleuromutilin Distribution

Widely distributed in most tissues and intracellularly.

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Pleuromutilin Metabolism

They are metabolized rapidly, leading to a short half-life.

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Pleuromutilin Interaction

They interact with ionophores, potentially leading to toxicity.

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Pleuromutilin Mechanism

Inhibition of the 50S ribosomal subunit, preventing protein synthesis.

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Pleuromutilin Spectrum

Broad spectrum.

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Pleuromutilin vs Macrolides

More effective against Mycoplasma and anaerobes than macrolides.

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Pleuromutilin Resistance

Rapidly, with repeated exposure.

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Tiamulin Adverse Effect in Swine

Dermatitis

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Pleuromutilin Administration

Orally for swine.

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Growth promoters are irrational

It increases bacterial resistance, reducing long-term effectiveness.

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Pleuromutilin target in Swine

Respiratory diseases caused by Mycoplasma hyopneumoniae.

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Growth promotion is irrational

True

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