Podcast
Questions and Answers
What is the function of alpha granules in platelets?
What is the function of alpha granules in platelets?
- Absorb different components and substances (correct)
- Respond to hemostatic stimuli
- Facilitate clot retraction after activation
- Provide platelets with a negative charge
Which organelle zone of platelets is responsible for modulating platelet adhesion and clot retraction after activation?
Which organelle zone of platelets is responsible for modulating platelet adhesion and clot retraction after activation?
- Mitochondria
- Surface-Connected Canalicular System
- Submembrane region (correct)
- Golgi bodies
Why do platelets need to change shape when they are active?
Why do platelets need to change shape when they are active?
- To reduce their size
- To produce more platelets
- To increase their lifespan
- To release more granules and form a clot (correct)
Which organelle is responsible for producing and providing energy in platelets?
Which organelle is responsible for producing and providing energy in platelets?
What is the function of thrombostenin in platelets?
What is the function of thrombostenin in platelets?
Which organelle in platelets sequesters calcium and supports platelet activation?
Which organelle in platelets sequesters calcium and supports platelet activation?
What is the role of alpha granules in platelets?
What is the role of alpha granules in platelets?
How do microfilaments (actin-myosin) contribute to platelet function?
How do microfilaments (actin-myosin) contribute to platelet function?
What is the role of calcium in clot formation?
What is the role of calcium in clot formation?
Which organelle zone of platelets contains lysosomes that digest vessel wall matrix?
Which organelle zone of platelets contains lysosomes that digest vessel wall matrix?
What is the function of dense granules in platelets?
What is the function of dense granules in platelets?
What substances are stored in alpha granules of platelets?
What substances are stored in alpha granules of platelets?
Which of the following is a function of PDGF and BTG stored in platelet alpha granules?
Which of the following is a function of PDGF and BTG stored in platelet alpha granules?
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Study Notes
Platelet Granules and Organelles
- Alpha granules store and release proteins important for clotting, wound healing, and tissue repair, including PDGF and BTG.
- Dense granules contain substances like ADP, ATP, calcium, and serotonin, which are crucial for platelet activation and aggregation.
Platelet Activation and Shape Change
- Platelets must change shape from disc to spread out to enhance surface area for better adhesion to the site of injury and facilitate clot retraction.
- Thrombostenin, a contractile protein, aids in the contraction of the platelet cytoskeleton, promoting clot retraction after activation.
Energy and Calcium in Platelets
- Mitochondria are the organelles responsible for energy production, providing ATP needed for platelet activation and function.
- The dense tubular system in platelets sequesters calcium, which is essential for activating clotting factors and enabling platelet aggregation.
Microfilaments and Clot Formation
- Actin and myosin microfilaments play a significant role in the contraction of platelets, aiding in shape change and strengthening the formed clot by contracting and pulling back tissue.
Lysosomes and Vessel Matrix
- The lysosomal zone of platelets contains enzymes that digest the vessel wall matrix, facilitating the remodeling of the surrounding tissue during healing.
Role of Calcium
- Calcium ions act as signaling molecules in clot formation, essential for enzymatic reactions and the binding of platelets to each other and to the injury site.
Summary of Key Functions
- PDGF and BTG from alpha granules promote cell growth and tissue repair, playing vital roles in the healing process following vascular injury.
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