28 Questions
What is the initial event for thrombus formation in primary hemostasis?
Platelet adhesion
Which factor is the convergence point and common for both intrinsic and extrinsic pathways of coagulation?
Factor X
What catalyzes the formation of thrombin in the prothrombin complex?
Platelet factor 3
In the intrinsic pathway, what is activated first after exposed collagen?
Factor XII
Which pathway involves tissue factor from injured cells and factor VII?
Extrinsic pathway
What is the final product of the conversion of fibrinogen by thrombin?
Fibrin
Which of the following is NOT one of the three initial responses to vascular injury?
Thrombin generation
Which of the following is NOT a characteristic of heparin-induced thrombocytopenia (HIT)?
Forms a red clot
What is the recommended initial screen for diagnosing heparin-induced thrombocytopenia?
ELISA for heparin antibodies
Which disorder is characterized by resistance to activated protein C?
Factor V Leiden mutation
What is the primary treatment for anti-phospholipid antibody syndrome?
Both heparin and warfarin
Which factor is NOT a common cause of acquired hypercoagulability?
Sickle cell anemia
Which factor has the shortest half-life?
Factor VII
What is the key factor that helps in the crosslinking of fibrin?
Factor XIII
Which substance is released from endothelium and converts plasminogen to plasmin?
Tissue plasminogen activator
What is found in cryoprecipitate and used in von Willebrand's disease and hemophilia A?
von Willebrand factor and factor VIII
Which coagulation measurement is best for assessing heparin anticoagulation?
PTT
What is the most common cause of surgical bleeding due to incomplete hemostasis?
von Willebrand's disease
Which bleeding disorder leads to prolonged PTT and normal PT?
Hemophilia B
Which drug inhibits fibrinolysis by inhibiting plasmin?
ε-Aminocaproic acid
Which drug is a direct thrombin inhibitor with a half-life of 12 hours?
Dabigatran
What is the reversal agent for Pradaxa?
Praxbind
Which drug binds and activates anti-thrombin III and increases neutralization of factors IIa and Xa?
Heparin
Which drug is cleared by the reticuloendothelial system and has a half-life of 60–90 minutes?
Heparin
Which drug has a lower risk of heparin-induced thrombocytopenia (HIT) compared to unfractionated heparin?
Enoxaparin
Which drug is metabolized in the liver, has a half-life of 50 minutes, and is often used in patients with heparin-induced thrombocytopenia (HITT)?
Argatroban
Which drug is the most potent direct inhibitor of thrombin and has a high risk for bleeding complications?
Hirudin
Which drugs activate plasminogen to break down fibrinogen?
tPA and streptokinase
Test your knowledge of platelet disorders and their treatments with this quiz. Learn about conditions like thrombocytopenia and heparin-induced thrombocytopenia, as well as the appropriate treatments for these disorders.
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