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Questions and Answers
Which plasma protein has the highest concentration?
Which plasma protein has the highest concentration?
- Prothrombin
- Albumin (correct)
- Globulin
- Fibrinogen
What is the primary site of production for fibrinogen?
What is the primary site of production for fibrinogen?
- Lymph nodes
- Spleen
- Liver (correct)
- Bone Marrow
What is the approximate molecular weight range of Globulins?
What is the approximate molecular weight range of Globulins?
- 68,700
- 69,000
- 90,000-156,000 (correct)
- 340,000
What does a decrease in the Albumin/Globulin (A/G) ratio suggest?
What does a decrease in the Albumin/Globulin (A/G) ratio suggest?
Which plasma protein has the smallest molecular weight?
Which plasma protein has the smallest molecular weight?
Flashcards
Albumin
Albumin
A major plasma protein, synthesized in the liver, with the highest concentration and smallest molecular weight. It maintains blood volume and pressure, transports hormones, and helps with drug delivery.
Globulins
Globulins
A group of plasma proteins that are divided into alpha (α), beta (β), and gamma (γ) types.
Albumin/Globulin Ratio (A/G)
Albumin/Globulin Ratio (A/G)
The ratio of albumin to globulin protein levels in the blood, normally ranging from 1.2 to 1.6.
Fibrinogen
Fibrinogen
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Prothrombin
Prothrombin
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Study Notes
Plasma Protein Concentration
- Plasma proteins concentration ranges from 7.2 to 7.4 g/dL (grams per deciliter), equivalent to 72-74 g/L (grams per liter).
Plasma Protein Types
- Albumin: Concentration of 3.5-5 g/dL; Molecular weight of 69,000; Highest concentration, lowest molecular weight.
- Globulins: (α, β, γ); Concentration of ~ 2.5 g/dL; Molecular weight of 90,000-156,000.
- Fibrinogen: Concentration of ~0.4 g/dL; Molecular weight of 340,000.
- Prothrombin: Concentration of ~0.01 g/dL; Molecular Weight of 68,700.
Sites of Formation
- Albumin, fibrinogen, prothrombin: Primarily produced in the liver.
- Globulins: 50% produced in the liver; 50% produced by plasma cells within the reticuloendothelial system (RES).
Albumin/Globulin Ratio (A/G)
- Normal A/G ratio is 1.2-1.6.
- A decreased A/G ratio can indicate liver diseases (e.g., cirrhosis, hepatitis), kidney diseases (e.g., nephrosis), or infection.
- This decrease is often due to reduced albumin production or increased albumin loss in urine.
Additional Notes
- RES: Refers to a diffuse system of cells (macrophages) located in various organs including the liver, spleen, lymph nodes, and bone marrow.
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