Planning a Study: Data Collection & Random Sampling

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Questions and Answers

Considering a scenario where a sample is selected from a population with replacement, and given the complexities introduced by non-constant probabilities of selection, which of the following methods is MOST effective for minimizing bias in statistical inference?

  • Employing a Horvitz-Thompson estimator, appropriately weighted by the inverse of inclusion probabilities, especially when dealing with unequal selection probabilities to ensure unbiased estimation of population parameters. (correct)
  • Applying a stratified sampling technique to create homogeneous subgroups to reduce variability, followed by equal probability sampling within each stratum, and then aggregating the results.
  • Using a cluster sampling approach with a large number of small, heterogeneous clusters to mimic the population's variability and minimize the impact of intra-cluster correlation.
  • Implementing a systematic sampling method with a randomly selected starting point to ensure uniform coverage across the population and reduce the risk of selection bias.

In experimental design, the deliberate introduction of a confounding variable post hoc is an acceptable strategy to discern causal relationships more accurately, especially when initial analyses are inconclusive.

False (B)

Describe a sophisticated methodology beyond simple random sampling that significantly improves the precision of estimating population parameters in a heterogeneous population, justifying its effectiveness through the lens of variance reduction. How do you ensure that your choice avoids introducing bias related to cluster effects or stratification?

Employ stratified sampling with optimal allocation, where strata are formed based on auxiliary information highly correlated with the outcome variable. Allocate sample sizes to each stratum inversely proportional to the square root of the within-stratum variance and proportional to stratum size, minimizing the overall variance of the estimator. In order to avoid bias, perform appropriate weighting based on sampling fractions. Furthermore, this needs to be compared to other methods, such as simple random sampling.

In the context of experimental design, the process of ________ is employed to mitigate the effects of unknown confounding variables by ensuring that, on average, treatment groups are balanced with respect to these variables, thereby strengthening causal inferences.

<p>random assignment</p> Signup and view all the answers

Match the following statistical study types with their appropriate definitions:

<p>Observational Study = A study in which individuals are observed, and variables of interest are measured, without any attempt to influence the responses; treatments are not imposed. Experimental Study = A study in which a treatment is deliberately imposed on individuals in order to observe their responses. Retrospective Study = An observational study that examines existing data for a sample of individuals. Prospective Study = An observational study that tracks individuals into the future to collect data as it unfolds.</p> Signup and view all the answers

In the realm of probabilistic inference, consider a scenario where the occurrence of event A provides absolutely no incremental information regarding the likelihood of event B, and vice versa. Given this condition, and assuming that both events A and B have non-zero probabilities, which of the following statements MUST invariably hold true?

<p>$P(A \cup B) = P(A) + P(B) - P(A) \times P(B)$ and $P(A \cap B) = P(A) \times P(B)$, satisfying both the addition rule for the union of independent events and the multiplication rule for their intersection. (D)</p> Signup and view all the answers

In the context of statistical simulations designed to approximate complex stochastic processes, augmenting the number of iterations ad infinitum reliably guarantees convergence to the true probability, irrespective of the inherent biases embedded within the generative model itself.

<p>False (B)</p> Signup and view all the answers

Propose a stratified sampling strategy that optimizes estimation precision given a fixed budget and a population with known auxiliary variables correlated with the outcome, detailing how to balance stratum sizes and sample allocation to minimize variance while accounting for sampling costs and potential non-response bias.

<p>Implement Neyman allocation within strata defined by auxiliary variables highly correlated with the outcome. Adjust sample sizes in each stratum proportional to stratum size and inversely proportional to the square root of within-stratum variance, factoring in stratum-specific sampling costs. Furthermore, address potential non-response by oversampling in strata with higher non-response rates and implement weighting adjustments using propensity scores.</p> Signup and view all the answers

In hypothesis testing, the ________ represents the probability of observing a test statistic as extreme as, or more extreme than, the statistic obtained from a sample, assuming that the null hypothesis is true.

<p>p-value</p> Signup and view all the answers

Match the following statistical biases with their definitions:

<p>Voluntary Response Bias = Bias arising when individuals self-select to participate in a study, leading to a sample that is not representative of the population. Undercoverage Bias = Bias resulting from some members of the population being inadequately represented in the sample. Non-response Bias = Bias that occurs when a significant number of people in the selected sample do not respond to the survey, and these non-respondents differ in important ways from those who do respond. Response Bias = Bias resulting from inaccurate or untruthful answers provided by respondents.</p> Signup and view all the answers

Flashcards

Population

The entire group of individuals about which we want information.

Sample

A subset of individuals selected from a population to collect data.

Observational Study

Observing individuals and measuring variables without influencing responses or imposing treatments.

Simple Random Sample (SRS)

Selecting a sample of size n where every set of n elements has an equal chance of being chosen.

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Stratified Random Sample

A sampling technique where the population is divided into subgroups (strata), and random samples are taken from each subgroup.

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Cluster Sample

A sampling approach where entire groups (clusters) are chosen at random.

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Systematic Sample

Selecting individuals systematically from a sampling frame (e.g., every 10th person).

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Census

Examination of information from all items, subjects, or people in a population.

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Random Assignment

Assigning experimental units to treatments using a chance process.

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Placebo

A 'fake' treatment with no active ingredients; provides a control for the experiment.

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Study Notes

  • Data collection methods not relying on chance can lead to untrustworthy conclusions.

Introduction to Planning a Study

  • Population refers to the entire group of individuals for the desired information.
  • Sample refers to a subset of individuals from the population.
  • Observational study involves observing individuals and measuring variables without influencing responses or imposing treatments.
  • Retrospective observational studies examine existing data from a sample.
  • Prospective observational studies track individuals into the future.
  • Sample Survey is a type of observational study using an organized plan to choose a sample representing a specific population.
  • Experimental Study involves deliberately imposing a treatment to observe responses.
  • Samples should fairly represent the population and provide information specifically for that the population.
  • Observational studies do not demonstrate cause-and-effect relationships.

Random Sampling and Data Collection

  • Sampling method refers to a technique or plan for selecting a sample.
  • Sampling without replacements: Items can be selected only once
  • Sampling with replacements: Items can be selected more than once
  • Simple Random Sample (SRS) refers to a sample size n where each set of n elements has an equal chance of selection.
    • SRS is easy and unbiased.
    • SRS requires knowledge of the population.
  • Stratified Random Sample: The population is divided into subgroups or strata, and random samples are taken from each stratum.
    • Stratified Sampling is more precise than SRS and can reduce costs where strata is available.
    • Stratified Sampling can be difficult to implement due to complex formulas and the need to know the population.
  • Cluster Sample: Entire groups (clusters) are chosen at random based on location.
    • Cluster Sampling reduces cost, is unbiased, and does not require population knowledge.
    • Cluster Sampling may not be representative and has complex formulas.
  • Systematic Sample: Individuals are selected systematically from a sampling frame.
    • Systematic Samples are unbiased, evenly distributed, and do not require population knowledge.
    • Systematic Samples can be confounded by trends.
  • Census examines information from all items, subjects, or people in a population.
    • Census provides comprehensive and accurate data collection.
    • Census is difficult, expensive, time-consuming, and complex.

Potential Problems with Sampling

  • Bias: Certain values/responses are more likely to be obtained than others.
  • Voluntary Response Bias: People choose to participate.
  • Convenience Sampling: Asking people who are easily accessible or friendly.
  • Under-coverage: Some groups are excluded from the selection process.
  • Non-response: Individuals cannot or do not want to participate.
  • Response Bias: False answers given due to a variety of reasons.
  • Wording of Questions: Leading questions introduce bias.
  • Order of Choice: Leaning towards the first choice.

Introduction to Experimental Design

  • Experimental units: The smallest collection of individuals to which treatments are applied; when units are human beings, they are called subjects.
  • Explanatory variable: The variable being manipulated in an experiment; its different values are called treatments.
  • Response variable: The outcome measured to determine the effects of treatments.
  • Confounding variables: Potential problems that may affect the response and create misleading relationships between explanatory and response variables.
  • A well-designed experiment includes:
    • Comparing multiple groups, including a control group.
    • Randomly assigning treatments.
    • Repeating with multiple units.
    • Controlling other influencing factors.
  • Completely Randomized Design: Each subject has an equal chance of receiving any treatment.
  • Random Assignment: Experimental units are assigned using a chance process.
  • Blinding: A method to keep subjects unaware of the treatment they are receiving.
    • Single Blind: Either subjects or evaluators are blinded, but not both.
    • Double Blinding: Neither subjects nor evaluators know which treatment is given.
  • Control Group: A group used for comparison to assess the effectiveness of a treatment, not necessarily a placebo.
  • Placebo: A "fake" treatment with no active ingredients that provides a baseline for comparison.
  • Placebo Effect: A tendency in human subjects to exhibit a response even to a placebo, often seen in 20%+ of subjects.
  • Blocking: Grouping similar subjects into blocks before the experiment.
  • Matched pairs design: Subjects are arranged into pairs based on similar factors, then randomly split into treatment groups.
  • Each experimental design has its advantages and disadvantages depending on the question of interest, available resources, and nature of the experimental units.
  • Statistical inference draws conclusions from data distribution.
  • Statistically significant: Random treatment assignment showing changes unlikely by chance.
  • Differences in treatment groups suggest treatment effects; results can apply to larger, representative groups if random selection is used.

Probability, Random Variables, and Probability Distributions

  • Law of large numbers: As a chance process is repeated, the proportion of times a specific outcome occurs approaches a single value.
  • The probability of any outcome is a number between 0 and 1.
  • Probability does not allow short-run predictions.

Simulation

  • Simulation is imitating a chance behavior based on a model that reflects the situation.
  • To perform a simulation. Follow these four steps:
    • State
    • Plan
    • Do
    • Conclude

Probability

  • Sample space S: The set of all possible outcomes.
  • Probability model: Description of some chance process that includes a sample space S and a probability for each outcome.
  • Event: Any collection of outcomes from a chance process, a subset of the sample space.
  • If all outcomes are equally likely, probability is found by dividing the number of outcomes corresponding to event A.
  • The probability that an event does not occur is 1 minus the probability that the event does occur.
  • If two events have no outcomes in common, the probability of one or the other occurs is the sum of their probabilities.
  • For any event A, between 0 and 1.
  • If S is the sample space in a probability model, equal to 1.
  • Complement rule: P(A^c) = 1- P(A)
  • Mutually Exclusive: When two outcomes can rarely occur at the same time P(A and B) = O
  • The complement A contains exactly the outcomes that are not in A.
  • Mutually exclusive (disjoint) events A and B do not overlap.
  • The intersection of events A and B is the set of all outcomes in both A and B.
  • The union of events A and B is the set of all outcomes in either event A or B.

Conditional Probability

  • Conditional Probability: When one event happens, given that another event happened.
    • If A has happened, then the probability that B happens given that A happened
  • General Multiplication Rule says that for both of 2 events to occur, first one must occur and then the second event must follow
  • Tree diagram can be used to display a sample space in a sequence of outcomes
  • Two events A and B are independent if the occurrence of one event does not change the probability that the other event will happen.
  • Multiplication rule for independent events: If A and B are an independent event, then the probability that A and B both occur.

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