PK: Metabolism and Excretion Quiz
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Questions and Answers

What are some examples of drugs that are substrates for CYP2C9 isoenzyme?

Ibuprofen, warfarin, tolbutamide

Which enzyme is responsible for the metabolism of codeine, metoprolol, and debrisoquine?

CYP2D6

Name an example of an inhibitor of CYP2C9 isoenzyme.

Amiodarone

What is the main location of cytochrome P450 (CYP450) oxidase enzymes?

<p>Inner membrane of mitochondria, Smooth endoplasmic reticulum (SER), Mucosa of the GI tract, The liver</p> Signup and view all the answers

Which phase of metabolism involves oxidations, reductions, hydrolysis, and glucuronide conjugation?

<p>Phase II</p> Signup and view all the answers

What are some examples of nonmicrosomal drug metabolizing enzymes?

<p>Flavoprotein oxidases, esterases, amidases, conjugases</p> Signup and view all the answers

Which P450 isoenzyme is responsible for metabolizing ciclosporin, nifedipine, indinavir, and simvastatin?

<p>CYP3A4</p> Signup and view all the answers

What is the genetic variation that leads to different acetylation rates in acetyl transferase?

<p>Genetic polymorphism</p> Signup and view all the answers

Name an example of an inducer of CYP2D6 isoenzyme.

<p>None known</p> Signup and view all the answers

Which drug is a substrate for CYP2C9 isoenzyme and also for CYP3A4 isoenzyme?

<p>Simvastatin</p> Signup and view all the answers

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