10 Questions
What are some examples of drugs that are substrates for CYP2C9 isoenzyme?
Ibuprofen, warfarin, tolbutamide
Which enzyme is responsible for the metabolism of codeine, metoprolol, and debrisoquine?
CYP2D6
Name an example of an inhibitor of CYP2C9 isoenzyme.
Amiodarone
What is the main location of cytochrome P450 (CYP450) oxidase enzymes?
Inner membrane of mitochondria, Smooth endoplasmic reticulum (SER), Mucosa of the GI tract, The liver
Which phase of metabolism involves oxidations, reductions, hydrolysis, and glucuronide conjugation?
Phase II
What are some examples of nonmicrosomal drug metabolizing enzymes?
Flavoprotein oxidases, esterases, amidases, conjugases
Which P450 isoenzyme is responsible for metabolizing ciclosporin, nifedipine, indinavir, and simvastatin?
CYP3A4
What is the genetic variation that leads to different acetylation rates in acetyl transferase?
Genetic polymorphism
Name an example of an inducer of CYP2D6 isoenzyme.
None known
Which drug is a substrate for CYP2C9 isoenzyme and also for CYP3A4 isoenzyme?
Simvastatin
Test your knowledge on metabolism, drug metabolizing enzymes, metabolic reactions, and drug excretion routes like through milk, lungs, and enterohepatic pathway.
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