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Questions and Answers
What is the main function of the tropic hormones of the anterior pituitary?
What is the role of the hypothalamic-hypophysial portal system?
What is the effect of insulin-like growth factor-1 (IGF-1) on growth hormone secretion?
What is the physiological effect of antidiuretic hormone (ADH)?
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What is the main difference between the anterior and posterior pituitary glands?
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What is the primary function of the hormone produced by lactotropes in the anterior pituitary gland?
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What is the name of the bony structure that the pituitary gland resides in?
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What is the term for the hormones produced by the anterior pituitary gland that stimulate other endocrine glands?
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What is the name of the surgical procedure that removes pituitary tumors through the nose?
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What is the primary role of the hypothalamus in the endocrine system?
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What type of hormones does the hypothalamic neurons synthesize?
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What is the function of the hypothalamic-hypophysial portal system?
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What is the effect of releasing hormones on the anterior pituitary?
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What is the function of the hypothalamic-pituitary axis?
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What is the role of the median eminence in the hypothalamic-pituitary axis?
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What is the difference between short-loop and long-loop feedback in the hypothalamic-pituitary axis?
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What is the hypothalamic-neurohypophyseal axis responsible for?
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What is the function of growth hormone-inhibiting hormone (GHIH)?
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Which hormone is predominantly under negative control from the hypothalamus?
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What is the primary function of Growth Hormone in early development?
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Which of the following is a characteristic of the somatotropic axis?
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What is the primary function of Insulin-Like Growth Factor-1 (IGF-1)?
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What is the result of excessive Growth Hormone secretion before the closure of epiphyses?
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What is the effect of Growth Hormone on glucose metabolism?
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Which of the following is a factor that increases Growth Hormone secretion? (2)
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What is the result of Growth Hormone deficiency in childhood?
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What is the primary function of Growth Hormone in adults?
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What is the effect of Insulin-Like Growth Factor-1 (IGF-1) on somatostatin neurons?
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What is the primary function of antidiuretic hormone (ADH) in the body?
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Where are the peptide pre-hormones neurophysins processed into oxytocin and antidiuretic hormone?
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What is the result of a deficiency of antidiuretic hormone (ADH) in the body?
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What is the mechanism of secretion of antidiuretic hormone (ADH) in response to increased osmolality of blood?
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What is the role of oxytocin in labor?
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What is the result of excess antidiuretic hormone (ADH) in the body?
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What is the function of neurophysins in the transport of oxytocin and antidiuretic hormone?
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What is the effect of oxytocin on the lactating breast?
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What is the effect of antidiuretic hormone (ADH) on blood pressure?
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Study Notes
Posterior Pituitary Gland and Its Relation to the Hypothalamus
- The posterior pituitary gland produces two hormones: ADH (antidiuretic hormone) and OT (oxytocin)
- Both hormones are produced in the hypothalamic nuclei, specifically in the supraoptic nucleus (SON) and paraventricular nucleus (PVN)
- ADH (arginine vasopressin) controls water balance in the body, concentrates urine, and promotes vasoconstriction
- Oxytocin (OT) is a maternal hormone involved in parturition, lactation, and natriuretic peptide, and inhibits salt appetite
Hypothalamic Nuclei
- Most cells in the hypothalamic nuclei express ADH or OT, with 2-3% expressing both hormones
- The hormones are transported with neurophysins (carrier proteins) to the axon terminals and stored in the posterior pituitary gland
- Both hormones are secreted by exocytosis
ADH (Antidiuretic Hormone)
- Mechanism of secretion: osmoreceptors in the hypothalamus sense changes in blood osmolality, sending nerve impulses to the posterior pituitary to stimulate ADH secretion
- ADH increases fluid retention in the kidneys, promotes vasoconstriction, and stimulates the insertion of aquaporins into the luminal membranes of the connecting tubule and collecting duct cells
Abnormalities of ADH
- Deficiency: central diabetes insipidus, characterized by the excretion of large volumes of dilute urine (polyuria)
- Excess: nephrogenic diabetes insipidus, characterized by ADH resistance in the kidneys, leading to polyuria
Physiological Effects of Oxytocin
- Potentiates smooth muscle contraction during labor, stimulates milk ejection from the lactating breast, and promotes uterine contractions
- Stimulates the incorporation of gap junctions between uterine smooth muscle cells
Growth Hormone (GH)
- Produced by the anterior pituitary gland, regulates growth and development from infancy to adulthood
- Stimulates the liver to produce insulin-like growth factor-1 (IGF-1), which promotes growth and development
The Somatotropic Axis
- Regulates the release of GH, which stimulates the liver to produce IGF-1
- IGF-1 directly inhibits GH release from the anterior pituitary, creating a negative feedback loop
Negative Feedback Regulation of GH
- GH stimulates IGF-1 secretion, which directly inhibits GH release from the anterior pituitary
- IGF-1 also indirectly inhibits GH secretion by suppressing GHRH secretion and increasing somatostatin secretion
Insulin-Like Growth Factor-1 (IGF-1) and Body Size
- IGF-1 is primarily responsible for the effects of GH on growth and development
- Stimulates cell division and differentiation, promoting linear growth in long bones and bone diameter
Stimulation of Growth by GH
- GH works directly on specific tissues to produce acute metabolic effects that oppose the effects of insulin
- Stimulates cell production, lipolysis, and glucose sparing in various tissues
Age and GH
- GH secretion peaks during puberty and declines with aging
- Effects on protein synthesis are most apparent in children, while in adults, GH helps maintain normal blood glucose and mobilize lipid stores
GH Secretion
- Control of GH secretion is regulated by the hypothalamus, which releases GHRH and somatostatin to stimulate and inhibit GH secretion, respectively
- Factors that increase GH secretion include hypoglycemia, increased plasma concentration of amino acids, deep sleep, acute physical stress, and starvation
- Factors that decrease GH secretion include hyperglycemia, elevated plasma free fatty acids, aging, obesity, and exogenous GH
Abnormalities Related to GH Deficiency
- Alterations in GH lead to panhypopituitarism, a condition characterized by decreased secretion of all anterior pituitary hormones
- Pituitary dwarfism is a result of GH deficiency in childhood, leading to growth cessation and lack of secondary sex characteristics
Abnormalities Related to GH Excess
- Alterations in GH lead to gigantism, a condition characterized by excessive growth and height
- Acromegaly, a condition characterized by excessive bone growth and soft tissue growth after adolescence, leading to enlarged hands and feet, and soft tissue swelling
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