Pituitary and Adrenal Hormones

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Questions and Answers

A patient with suspected Cushing's syndrome is undergoing initial diagnostic testing. If the syndrome is caused by a pituitary adenoma, what pattern of ACTH and cortisol levels would be expected?

  • Elevated ACTH, low cortisol
  • Low ACTH, low cortisol
  • Low ACTH, elevated cortisol
  • Elevated ACTH, elevated cortisol (correct)

Following a thyroidectomy, a patient reports tingling around their mouth and fingertips. What electrolyte imbalance is the MOST likely cause of these symptoms, and what immediate intervention is indicated?

  • Hypokalemia; administer IV potassium chloride
  • Hypocalcemia; administer IV calcium gluconate (correct)
  • Hypernatremia; restrict sodium intake
  • Hypermagnesemia; administer IV loop diuretics

A patient with known diabetes insipidus (DI) is scheduled for a water deprivation test to assess the severity of their condition. Before initiating the test, which of the following conditions must be ruled out to ensure patient safety?

  • Hypovolemia (correct)
  • Hyperglycemia
  • Hypokalemia
  • Hyponatremia

A patient with a history of hyperthyroidism is admitted with fever, tachycardia, and altered mental status, suggesting thyroid storm. Which initial nursing intervention is MOST crucial for this condition?

<p>Administering supplemental oxygen and cooling measures (A)</p>
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A patient with Addison's disease is admitted to the hospital for an elective hip replacement surgery. The patient's home medication is hydrocortisone 20mg in the morning and 10mg in the afternoon. Which of the following orders from the provider should the nurse clarify prior to surgery?

<p>Administer hydrocortisone 100mg IV pre-operatively, then 50mg IV every 8 hours for 24 hours, tapering to home dose (C)</p>
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A patient with acromegaly is scheduled for a transsphenoidal hypophysectomy. Preoperatively, the nurse emphasizes the importance of avoiding activities that increase intracranial pressure (ICP). Which instruction below is MOST appropriate?

<p>&quot;Avoid bending at the waist or straining during bowel movements.&quot; (D)</p>
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A type 1 diabetic patient who has been diligently managing their diabetes presents at their annual wellness check-up. The patients most recent A1C is 9.8%. Despite having a good understanding of nutrition principles, using appropriate insulin administration technique, and monitoring blood glucose levels four times per day, the patient's glycemic control is consistently poor. What condition may contribute to this patient's poor glycemic control?

<p>Celiac disease (A)</p>
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What key difference differentiates the action of sulfonylureas and metformin in managing type 2 diabetes mellitus?

<p>Sulfonylureas stimulate insulin release from pancreatic beta cells, while metformin decreases liver glucose production and increases insulin sensitivity (D)</p>
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A patient with severe diabetic ketoacidosis (DKA) has been receiving IV insulin and fluids for several hours. The laboratory results now show a blood glucose of 210 mg/dL, pH of 7.32, bicarbonate of 16 mEq/L, and serum potassium of 3.1 mEq/L. Which intervention is the MOST appropriate at this time?

<p>Add dextrose to the IV fluids and continue the insulin infusion while administering IV potassium (D)</p>
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A patient is prescribed desmopressin for the treatment of central diabetes insipidus. What adverse effect would warrant immediate discontinuation of the medication?

<p>Weight gain of 3 lbs in one day and development of muscle cramps (D)</p>
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A patient with a history of Graves' disease is scheduled to receive radioactive iodine (RAI) therapy. The patient expresses concern about potential long-term effects. What is the MOST appropriate response?

<p>&quot;RAI therapy may lead to hypothyroidism, requiring lifelong thyroid hormone replacement. We will monitor you closely.&quot; (D)</p>
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What specific recommendation should a nurse provide to a patient scheduled for an oral glucose tolerance test (OGTT) to ensure accurate results?

<p>&quot;Consume a high-carbohydrate diet (at least 150 grams) for three days prior to the test.&quot; (A)</p>
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A patient with a known pituitary tumor is being evaluated for hypopituitarism. Which of the following clinical manifestations would require the MOST immediate intervention?

<p>Postural hypotension and hyponatremia (B)</p>
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During a follow-up appointment, a patient with type 2 diabetes reports experiencing frequent episodes of hypoglycemia, despite adhering to their prescribed medication regimen of metformin and a sulfonylurea. What is the MOST appropriate INITIAL intervention to address this issue?

<p>Educate the patient on the importance of consuming a bedtime snack containing protein and complex carbohydrates. (D)</p>
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A patient being treated for SIADH (syndrome of inappropriate antidiuretic hormone) develops confusion, muscle twitching, and has a serum sodium level of 118 mEq/L. What is the MOSTappropriate intervention the nurse should anticipate?

<p>Administering hypertonic saline (3% NaCl) with close monitoring in an intensive care setting (D)</p>
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What is the underlying cause of the Somogyi effect in a type 1 diabetic patient, and how is it typically managed?

<p>Nocturnal hypoglycemia triggering a counterregulatory hormone response, resulting in morning hyperglycemia; managed by reducing the evening insulin dose or providing a bedtime snack. (B)</p>
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A patient with long-standing type 2 diabetes develops nephropathy. The provider prescribes a sodium-glucose cotransporter 2 (SGLT2) inhibitor. What additional benefit, besides glucose control, can this medication class provide for this patient?

<p>Weight loss and cardiovascular protection (B)</p>
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Prior to initiating metformin therapy, what laboratory assessment is MOST critical to evaluate for patient safety?

<p>Renal function tests (A)</p>
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A patient with Hashimoto's thyroiditis is started on levothyroxine. What specific symptom, if reported by the patient, requires the MOST urgent follow-up with the provider?

<p>Palpitations and chest pain (D)</p>
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A patient with hyperparathyroidism is undergoing preoperative teaching for a parathyroidectomy. What crucial information should the nurse include regarding potential postoperative complications?

<p>The possibility of developing hypocalcemia and signs of tetany (A)</p>
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A 45-year-old female presents with a constellation of symptoms including central obesity, easy bruising, thin skin, and elevated blood pressure. Initial laboratory findings reveal hyperglycemia and hypokalemia. Which of the following hormonal imbalances is the MOST likely underlying cause of these manifestations?

<p>Overproduction of cortisol due to an adrenal adenoma. (A)</p>
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A 30-year-old patient is being evaluated for possible acromegaly. An initial test reveals elevated levels of Insulin-like Growth Factor-1 (IGF-1). Which of the following is the MOST reliable confirmatory test to definitively diagnose acromegaly?

<p>Oral glucose tolerance test (OGTT) with growth hormone (GH) measurement. (A)</p>
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A 55-year-old male with a history of type 2 diabetes mellitus presents to the emergency department with altered mental status, severe dehydration, and a serum glucose level of 950 mg/dL. Arterial blood gas analysis reveals a normal pH and bicarbonate level. Which of the following is the MOST likely diagnosis?

<p>Hyperosmolar hyperglycemic state (HHS). (C)</p>
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A 62-year-old female with longstanding type 2 diabetes mellitus and known cardiovascular disease is started on canagliflozin, an SGLT2 inhibitor. Which of the following potential adverse effects should the nurse prioritize in patient education due to the patient's comorbidities?

<p>Increased risk of bone fractures and lower limb amputations. (B)</p>
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A 28-year-old female presents with secondary amenorrhea and galactorrhea. Her serum prolactin level is significantly elevated. After ruling out pregnancy and medication-induced hyperprolactinemia, what is the MOST appropriate next step in the evaluation of this patient?

<p>Order a brain MRI with a focus on the pituitary gland. (A)</p>
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A 34-year-old male presents with symptoms of fatigue, weight gain, constipation, and cold intolerance. Laboratory results show a low free T4 level and a normal TSH level. Which of the statements MOST accurately reflects the underlying etiology and appropriate management?

<p>This patient has central (secondary) hypothyroidism and requires further evaluation of the pituitary gland. (A)</p>
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A 68-year-old male with a history of hyperparathyroidism presents with fatigue, bone pain, and constipation. Serum calcium is elevated at 12.5 mg/dL. Which of the following interventions is MOST critical in the immediate management of this patient?

<p>Aggressive intravenous hydration with normal saline. (C)</p>
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A 50-year-old female undergoes a total thyroidectomy for papillary thyroid cancer. Postoperatively, she develops muscle spasms, facial twitching, and numbness around her mouth. Which of the following electrolyte abnormalities is the MOST likely cause, and what is the MOST appropriate initial intervention?

<p>Hypocalcemia; administer intravenous calcium gluconate. (D)</p>
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A 40-year-old patient with a known pituitary adenoma presents with worsening visual field deficits, specifically bitemporal hemianopsia. Which of the following mechanisms BEST explains the cause of this visual disturbance?

<p>Compression of the optic nerves at the optic chiasm. (B)</p>
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A patient with known diabetes insipidus (DI) is receiving desmopressin (DDAVP) intranasally. Which assessment finding BEST indicates that the medication is having the desired therapeutic effect?

<p>Decreased urine specific gravity. (B)</p>
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A patient with Addison's disease is admitted to the hospital for an unrelated surgical procedure. The patient reports taking hydrocortisone 20 mg in the morning and 10 mg in the afternoon. The surgical team plans to administer etomidate for anesthesia induction. What is the MOST important consideration regarding the patient's steroid replacement during and after the procedure?

<p>The patient requires stress-dose steroids due to the increased physiological demands of surgery. (C)</p>
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A 25-year-old patient presents to the clinic complaining of heat intolerance, anxiety, and frequent bowel movements. Physical examination reveals a fine tremor and a diffusely enlarged thyroid gland. Which diagnostic test would BEST confirm the suspected diagnosis?

<p>Thyroid-stimulating immunoglobulin (TSI) assay. (A)</p>
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In a patient with suspected pheochromocytoma, which of the following 24-hour urine test results would provide the STRONGEST evidence supporting the diagnosis?

<p>Elevated vanillylmandelic acid (VMA) and metanephrines. (B)</p>
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A patient with a history of panhypopituitarism is being treated with multiple hormone replacement therapies. Which combination of medications requires CAREFUL monitoring for potential drug interactions and overlapping side effects?

<p>Corticosteroids and growth hormone. (C)</p>
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A 22-year-old primigravida develops Sheehan's syndrome following a severe postpartum hemorrhage. Which of the following clinical manifestations would necessitate the MOST urgent intervention?

<p>Hypotension and altered mental status. (A)</p>
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In managing a patient with severe hyperthyroidism (thyroid storm), which of the following medication combinations would be MOST effective in addressing the multiple facets of the condition?

<p>Propylthiouracil (PTU), propranolol, and potassium iodide. (C)</p>
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A patient with type 1 diabetes is started on pramlintide in addition to their insulin regimen. What is the MOST important teaching point regarding the administration of this medication to prevent adverse effects?

<p>Reduce mealtime insulin dose when starting pramlintide. (B)</p>
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A patient with diabetes is prescribed repaglinide. Which instruction is MOST important to provide the patient regarding when to take this medication?

<p>Take it 1 to 30 minutes before each meal. (C)</p>
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Which signs and symptoms indicate to the nurse that the patient's diabetes is worsening?

<p>Breath smells fruity/sweet, client has been nauseous/vomiting, ketones present in blood, BGL 300, Kussmaul respirations. (D)</p>
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A client with mild hypoglycemia is prescribed fruit juice to increase blood levels. Which is the MOST important step?

<p>Follow the rule of 15s, provide 15 grams of carbs, recheck blood sugar in about 15 minutes. (C)</p>
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A client is diagnoses with Addison's disease. Which are important teaching points for this patient?

<p>This requires a life-sustaining medication that must be taken every day, and if someone is vomiting/experiencing diarrhea they should go to the ED to get hydrocortisone IV. (A)</p>
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What are important indicators of fluid overload that must be monitored at least every 2 hours in a client with Cushing's?

<p>Bounding pulse, increasing neck vein distention, lung crackles, increasing peripheral edema, and reduced urine output. (E)</p>
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What are important teaching points for patients who require Radioactive Iodine (RAI)?

<p>Use the same toilet for at least 2 weeks after treatment, sit to urinate to avoid splashing is spilled use towels to clean up then seal in plastic bags and take to hospital's radiation therapy department; women with urinary incontinence should use facial tissue layers in their clothing to catch the urine. (E)</p>
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Match the following: 1) Hypoglycemia and 2) Hyperglycemia with A) Cool, clammy, sweaty skin and B) Anxious and irritable mental state.

<p>1A, 2B (B)</p>
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Flashcards

Anterior Pituitary Hormone

ACTH; Stimulates synthesis and adrenal cortical hormones.

Anterior Pituitary Hormone

FSH; Females: Stimulates ovarian follicle growth and ovulation. Males: Stimulates sperm production.

Anterior Pituitary Hormone

GH; Stimulates bone and muscle growth, promotes protein synthesis and fat metabolism, decreases carbohydrate metabolism.

Anterior Pituitary Hormone

LH; Females: Stimulates corpus luteum development, release of oocyte, and estrogen and progesterone production. Males: Stimulates secretion of testosterone and development of the interstitial tissue of the testes.

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Anterior Pituitary Hormone

PRL; Prepares female breasts for lactation.

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Anterior Pituitary Hormone

TSH; Stimulates synthesis and secretion of thyroid hormone.

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Posterior Pituitary Hormone: Vasopressin (ADH)

Increases water reabsorption by the kidneys.

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Posterior Pituitary Hormone: Oxytocin

Stimulates uterine contractions; stimulates milk ejection from the breasts after birth

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Excess cortisol sx

Cushing's disease or syndrome, fat redistribution, thin skin, high blood pressure and hirsutism.

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Deficiency cortisol sx

Addison's disease; postural hypotension, hyperglycemia, malaise, hyponatremia, hyperkalemia, loss of axillary and pubic hair.

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Excess LH, FSH sx

Overstimulation of ovary. Usually asymptomatic.

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GH target hormone deficiency

Men- testicular failure with low T. Sx: low libido, facial and body hair loss, erectile dysfunction, loss of muscle mass; Women- anovulation, amenorrhea, infertility; Low bone density for both genders

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Excess prolactin sx

Galactorrhea, suppression of gonadotrophins (amenorrhea, low testosterone), infertility.

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Hypopituitarism causes

Compression by pituitary tumor, pituitary surgery, malnutrition/rapid loss of body fat, sepsis, head trauma, brain radiation, AIDS, Idiopathic, Sheehan syndrome

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GH target hormone excess

Acromegaly. Enlargement of face, hands, feet, heart, lungs, liver, OSA

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Diabetes insipidus s/sx

Increased urination, hypernatremia, dehydration. Poor skin turgor, dry or cracked mucous membranes. Output 4-30 L.

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SIADH s/sx

Confusion, muscle weakness, nausea, diarrhea, abdominal cramping. GI disturbances, lethargy, change in LOC, bounding pulse, hypothermia.

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Adrenal Insufficiency Pathophysiology

Inadequate secretion of ACTH (central AI), dysfunction of the hypothalamic-pituitary control mechanism, direct problems of adrenal gland tissue (Primary AI).

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Acute adrenal insufficiency crisis expected findings

Anemia, hypotension, hyponatremia, hyperkalemia, hypercalcemia, dehydration, hypoglycemia

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Cushing's diagnostic test

Dexamethasone suppression testing

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Cushing's History

Exogenous glucocorticoid therapy, other health problems (DM, HTN, osteoporosis, amenorrhea, GI ulcers), weight gain, increased appetite.

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Hypothyroidism Treatment

Synthroid, Levoxyl, Tirosint (levothyroxine) PO, IV Synthetic thyroxine (T4).

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Myxedema Coma S/sx

Facial swelling of the lips, eyelids, and tongue in patient with untreated hypothyroidism

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Thyroid storm S/Sx

Elevated temperature, hypertension, tachycardia.

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Hypoparathyroidism physical exam

Chvostek and Trousseau signs

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Type 2 Diabetes Mellitus

Insulin resistant, high sugar and carb intake, hereditary or environmental

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type 2 Diabetes Mellitus complications

Diabetes, retinopathy, nephropathy and neuropathy.

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Type 1 Diabetes Mellitus causes

Decreased insulin and high blood sugar

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Diabetes diagnostic findings

A1C >/=6.5%, Fasting BG > 126 mg/dL, OGTT 2 hr glucose > 200 mg/dL and Random BG > 200 mg/dL in a pt with sx hyperglycemia

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Type 2 Diabetes Mellitus treatment options

Diet, Medications: metformin and Can take insulin

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Sulfonylureas:

Glipizide (Glucotrol), glyburide, glimepiride (Amaryl)

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Metformin (Biguanides)

Decreases liver glucose production and decreases intestinal absorption of glucose; No hypoglycemia

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GLP1s Agonists

Act like natural “gut” hormones that work with insulin to lower blood glucose levels reducing pancreatic glucagon secretion, reducing liver glucose production, and delaying gastric emptying.

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Insulin type

Basal/Bolus: meant for mealtimes and correction

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Mild/ moderate Hypoglycemia

BG < 70 mg/dL follow the rule of 15. 15g carbs and recheck BG in 15 minutes.

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Hypoglycemia S/Sx

Anxious, nervous, *irritable, mental confusion, tachycardia, palpitations

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Hyperglycemic-Hyperosmolar State (HHS)

High serum osmolarity and BG

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Diabetic Ketoacidosis (DKA)

Severe metabolic acidosis and uncontrolled hyperglycemia. Nausea/vomitingRotting citrus fruit odor to the breathHypokalemia, Dehydration

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DKA Treatment

Provide insulin with a normal saline solution, and monitor

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Deficiency of TRH, TSH, T4, or T3

Weight gain, cold intolerance, hair loss, brittle nails, constipation, lethargy, slowed cognition.

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Excess of TRH, TSH, T4, or T3

Tachycardia, heat intolerance, anxiety, weight loss, diarrhea.

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Diabetes insipidus pathophysiology

Often a transient or permanent complication of pituitary surgery or Or Argenine vasopressin (ADH) resistance- inability of kidneys to respond to ADH AKA nephrogenic DI

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SIADH Severe Symptoms

Weight gain, lethargy, headache, hostility, change in LOC

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Acromegaly S/Sx

Thickened lips, Coarse facial features

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ACTH Levels in Adrenal Insufficiency

Primary: Elevated | Secondary: Low

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Acromegaly Diagnostic testing

Elevated IGF-1, Oral glucose tolerance test (OGTT): High levels of blood glucose typically suppress growth hormone

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Addison's Disease S/Sx

Neuromuscular: Muscle weakness, fatigue, joint and/or muscle pain

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Adrenal Insufficiency: Sick day rules & Surgery

For planned medical procedure, patients should double their dose the day before, the day of, and the day after the procedure.

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Cushing's ACTH Levels

In pituitary Cushing's, ACTH will also be high (Hyperpituitarism= negative feedback is lost)

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Hypoglycemic Problems

Hypoglycemic unawareness: pts no longer have early waring sx of hypoglycemia

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Study Notes

Acromegaly: Complications (Screening)

  • Osteoarthritis and Cardiovascular disease and Neuropathy including carpal tunnel

SIADH: Nursing Care

  • Use side rails and other safety measures
  • Fluid restriction & Monitor for fluid overload
  • Medications Use saline instead of water to dilute tube feedings, irrigate GI tubes, and give drugs by GI tube.

Adrenal Insufficiency: Risk Factors

  • Direct problems of adrenal gland tissue (Primary AI) results from Addison's Disease or adrenalectomy as well as metastatic cancer, certain strains of COVID, etc

Hyperthyroidism: Treatment

  • Priorities for nursing care focus on monitoring for complications, reducing stimulation, promoting comfort, teach pt and family therapeutic drugs/ procedures

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