Piperacillin/Tazobactam Flashcards

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Questions and Answers

What is the Zosyn dose for most infections?

  • 5.5 g q6h
  • 4.5 g q6h
  • 3.375 g q6h (correct)
  • 2.5 g q6h

What is the Zosyn dose for nosocomial pneumonia?

  • 4.5 g q6h (correct)
  • 6 g q6h
  • 5 g q6h
  • 3.375 g q6h

What is the therapeutic classification of Zosyn?

Anti-infective

What pharmacologic classification does Zosyn belong to?

<p>Extended spectrum penicillins</p> Signup and view all the answers

What are the actions of piperacillin in Zosyn?

<p>Binds to bacterial cell wall membrane, causing cell death (B)</p> Signup and view all the answers

What are some uses of Zosyn?

<p>Appendicitis, peritonitis, skin infections, gynecological infections, community-acquired and nosocomial pneumonia.</p> Signup and view all the answers

What are contraindications for Zosyn?

<p>Hypersensitivity to penicillins, beta-lactams, cephalosporins, renal impairment, sodium restriction.</p> Signup and view all the answers

What are some side effects of Zosyn?

<p>Diarrhea, rashes, pain/phlebitis at IV site (B)</p> Signup and view all the answers

What nursing implications are important for Zosyn?

<p>Evaluate renal and hepatic function, monitor signs and symptoms of infection and anaphylaxis, and infuse over 30 minutes.</p> Signup and view all the answers

What should patients be taught about Zosyn?

<p>Report rash and notify healthcare provider if fever, diarrhea, or blood/pus/mucus stool occurs.</p> Signup and view all the answers

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Study Notes

Zosyn Dosage

  • Administer IV for most infections at a dosage of 3.375 g every 6 hours.
  • For nosocomial pneumonia, increase dosage to 4.5 g every 6 hours.

Zosyn Classification

  • Therapeutic classification: anti-infective.
  • Pharmacologic classification: extended spectrum penicillins.

Zosyn Actions

  • Causes death of susceptible bacteria by binding to bacterial cell wall membranes, leading to cell death.
  • Piperacillin has an extended spectrum compared to other penicillins.
  • Tazobactam inhibits the enzyme beta-lactamase, which can inactivate penicillins.
  • Effective against piperacillin-resistant, beta-lactamase-producing organisms including:
    • Bacteroides fragilis
    • E. coli
    • Acinetobacter baumannii
    • Klebsiella pneumoniae
    • Pseudomonas aeruginosa
    • Staphylococcus aureus
    • Haemophilus influenzae

Zosyn Uses

  • Indicated for treatment of:
    • Appendicitis
    • Peritonitis
    • Skin infections
    • Gynecological infections
    • Community-acquired and nosocomial pneumonia caused by piperacillin-resistant, beta-lactamase-producing bacteria.

Zosyn Contraindications

  • Contraindicated in patients with hypersensitivity to penicillins, beta-lactams, or cephalosporins.
  • Use with caution in patients with renal impairment and sodium restriction.

Zosyn Side Effects

  • Common side effects:
    • Diarrhea
    • Rashes
    • Pain or phlebitis at the IV site.
  • Less common but serious side effects may include:
    • Anaphylaxis
    • Serum sickness
    • Seizures
    • Clostridioides difficile-associated diarrhea (CDAD)
    • Stevens-Johnson syndrome
    • Toxic epidermal necrolysis
    • Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).

Zosyn Nursing Implications

  • Evaluate renal and hepatic function, CBC, serum potassium levels, and bleeding times.
  • Collect specimen for culture and sensitivity before therapy.
  • Assess patient's history for reactions to penicillins.
  • Monitor for signs and symptoms of infection and anaphylaxis.
  • Regularly check bowel function and skin reactions.
  • Be vigilant for signs of DRESS: fever, rash, swelling, lymphadenopathy.
  • Administer infusion over 30 minutes.

Zosyn Patient Teaching

  • Advise patients to report rash or any skin reactions immediately.
  • Instruct to notify healthcare provider if experiencing fever, diarrhea, or blood/pus/mucus in stool.

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