Questions and Answers
What is the Zosyn dose for most infections?
What is the Zosyn dose for nosocomial pneumonia?
What is the therapeutic classification of Zosyn?
Anti-infective
What pharmacologic classification does Zosyn belong to?
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What are the actions of piperacillin in Zosyn?
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What are some uses of Zosyn?
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What are contraindications for Zosyn?
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What are some side effects of Zosyn?
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What nursing implications are important for Zosyn?
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What should patients be taught about Zosyn?
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Study Notes
Zosyn Dosage
- Administer IV for most infections at a dosage of 3.375 g every 6 hours.
- For nosocomial pneumonia, increase dosage to 4.5 g every 6 hours.
Zosyn Classification
- Therapeutic classification: anti-infective.
- Pharmacologic classification: extended spectrum penicillins.
Zosyn Actions
- Causes death of susceptible bacteria by binding to bacterial cell wall membranes, leading to cell death.
- Piperacillin has an extended spectrum compared to other penicillins.
- Tazobactam inhibits the enzyme beta-lactamase, which can inactivate penicillins.
- Effective against piperacillin-resistant, beta-lactamase-producing organisms including:
- Bacteroides fragilis
- E. coli
- Acinetobacter baumannii
- Klebsiella pneumoniae
- Pseudomonas aeruginosa
- Staphylococcus aureus
- Haemophilus influenzae
Zosyn Uses
- Indicated for treatment of:
- Appendicitis
- Peritonitis
- Skin infections
- Gynecological infections
- Community-acquired and nosocomial pneumonia caused by piperacillin-resistant, beta-lactamase-producing bacteria.
Zosyn Contraindications
- Contraindicated in patients with hypersensitivity to penicillins, beta-lactams, or cephalosporins.
- Use with caution in patients with renal impairment and sodium restriction.
Zosyn Side Effects
- Common side effects:
- Diarrhea
- Rashes
- Pain or phlebitis at the IV site.
- Less common but serious side effects may include:
- Anaphylaxis
- Serum sickness
- Seizures
- Clostridioides difficile-associated diarrhea (CDAD)
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).
Zosyn Nursing Implications
- Evaluate renal and hepatic function, CBC, serum potassium levels, and bleeding times.
- Collect specimen for culture and sensitivity before therapy.
- Assess patient's history for reactions to penicillins.
- Monitor for signs and symptoms of infection and anaphylaxis.
- Regularly check bowel function and skin reactions.
- Be vigilant for signs of DRESS: fever, rash, swelling, lymphadenopathy.
- Administer infusion over 30 minutes.
Zosyn Patient Teaching
- Advise patients to report rash or any skin reactions immediately.
- Instruct to notify healthcare provider if experiencing fever, diarrhea, or blood/pus/mucus in stool.
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Description
Test your knowledge on Piperacillin/Tazobactam (Zosyn) with this set of flashcards. Covering key topics such as dosing, classifications, and actions, this quiz is perfect for students and healthcare professionals looking to strengthen their understanding of this important antibiotic.
