Pioneers in Science: Jocelyn Bell Burnell & Tak Wah Mak

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Questions and Answers

In which year did Jocelyn Bell Burnell observe her first pulsar?

  • 1970
  • 1967 (correct)
  • 1965
  • 1968

What was a significant outcome of Tak Wah Mak's research on T-cells published in 1984?

  • Isolation of antigens associated with immune response
  • Development of a vaccine for Hodgkin's Lymphoma
  • Discovery of T-cell genetic encoding (correct)
  • Identification of cancer-specific T-cells

Which prestigious title was awarded to Jocelyn Bell Burnell in 2007?

  • Royal Astronomical Society Gold Medal
  • Dame Commander of the British Empire (correct)
  • Fellow of the Royal Society
  • Nobel Prize

What chemical compound did Tak Wah Mak identify in 1999 that could block the fuel supply of Hodgkin's Lymphoma?

<p>Monoclonal antibody (C)</p> Signup and view all the answers

Which area of study did Jocelyn Bell Burnell focus on while completing her PhD thesis?

<p>Quasars (C)</p> Signup and view all the answers

What was Tak Wah Mak's country of birth?

<p>China (B)</p> Signup and view all the answers

What novel aspect of pulsars was discovered by Jocelyn Bell Burnell and Antony Hewish?

<p>They emit radio waves at periodic intervals (C)</p> Signup and view all the answers

What did Tak Wah Mak receive in 1972 that marked the beginning of his research career?

<p>Fellowship at the Ontario Cancer Institute (C)</p> Signup and view all the answers

Flashcards

Jocelyn Bell Burnell's Contribution

Discovered pulsars, rapidly rotating neutron stars emitting radio waves. Her discovery lead to a new branch of astrophysics.

Pulsar

A rapidly rotating, strongly magnetized neutron star that emits pulses of radio waves.

T-cell receptor

Protein on the surface of immune cells (T-cells) that recognizes antigens (foreign substances).

Tak Wah Mak's Research

Focused on how T-cell receptors recognize and bind to antigens, ultimately solving a major immunology problem.

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Human T-cell receptor genetic encoding

Unique genetic sequence of receptors on T cells identified by Tak Wah Mak; vital to how they recognize and act against germs.

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Antony Hewish

Jocelyn Bell Burnell's supervisor who reported her pulsar discovery.

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Hodgkin's Lymphoma

A rare cancer that originates in the lymphatic system.

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T-cell receptor antigens

Foreign substances (e.g., bacteria, viruses) that trigger an immune response.

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Study Notes

Jocelyn Bell Burnell

  • Young postgraduate student
  • First scientist to detect pulsars
  • Opened new branch of astrophysics
  • Born in Northern Ireland
  • Developed interest in science in boarding school
  • Graduated from Glasgow University in 1965
  • Completed PhD thesis on quasars at Cambridge University
  • Worked under Antony Hewish
  • Designed and built radio telescope array
  • Discovered pulsars in 1967; radio waves pulsating every 1.337 seconds
  • Concluded pulsars were from rapidly rotating neutron stars emitting pulses
  • Given nickname "pulsar" in 1968
  • Awarded Dame Commander of the British Empire (DBE) in 2007
  • Supervisor received Nobel Prize in 1974

Tak Wah Mak

  • Immunologist and molecular biologist
  • Born in southern China in 1946
  • Studied at University of Wisconsin and University of Alberta
  • Discovered how T-cells recognize antigens (immune system)
  • PhD in biochemistry
  • Solved long-standing immunology problem
  • Discovered T-cell receptors' genetic sequence and origin in 1983
  • Opened new chapter in immune-system diseases study and treatment
  • Applied molecular techniques to study cancer
  • Quote: "We can never give up the fight against cancer" (2011)

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