Physiology Week 2: Muscle Function and Structure

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Questions and Answers

What is the resting potential of a nerve fiber in millivolts?

  • -50mV
  • -55mV
  • -70mV (correct)
  • -60mV

What is the primary reason for the diffusion of potassium ions out of the cell?

  • The leak channels in the nerve cell membrane
  • The high concentration of potassium ions in the extracellular fluid
  • The operation of the membrane pump
  • The negative charge of the proteins inside the cell (correct)

During the depolarization state, what ions are allowed to flow into the cell?

  • Potassium ions only
  • Sodium ions only (correct)
  • Chloride ions only
  • Sodium and potassium ions

What is the main function of the voltage-gated potassium channels during the repolarization state?

<p>To open slowly to allow potassium ions to flow out of the cell (B)</p> Signup and view all the answers

What is the term for the diffusion potential level across a membrane that exactly opposes the membrane becoming positively charged?

<p>Nernst potential (B)</p> Signup and view all the answers

What is the primary reason for the hyperpolarization state?

<p>The slow closure of potassium channels (C)</p> Signup and view all the answers

What is the absolute refractory period?

<p>The time needed for sodium channels to revert from inactivated to resting (B)</p> Signup and view all the answers

What is the consequence of the differential permeability of the membrane to ions?

<p>Ionic differences (B)</p> Signup and view all the answers

What is the primary reason for the high concentration of potassium ions in the cytosol?

<p>The operation of the membrane pump (D)</p> Signup and view all the answers

What is the primary function of the Na-K Pump in nerve cells?

<p>To transport 3 Na+ out and 2 K+ in (B)</p> Signup and view all the answers

What type of ion channels are opened during the local depolarization of the muscle fiber membrane?

<p>Nicotinic receptors (A)</p> Signup and view all the answers

What is the primary function of acetylcholinesterase in the neuromuscular junction?

<p>To remove acetylcholine from the synaptic cleft (D)</p> Signup and view all the answers

What is the term for the rapid removal of acetylcholine from the synaptic cleft?

<p>Hydrolysis (A)</p> Signup and view all the answers

What is the term for the process by which an action potential in a motor neuron triggers muscle contraction?

<p>Excitation-contraction coupling (D)</p> Signup and view all the answers

What is the primary cause of Myasthenia Gravis?

<p>Abnormal reduction in acetylcholine receptors (D)</p> Signup and view all the answers

What is the primary function of the active zone in the presynaptic terminal?

<p>To hold synaptic vesicles in place (B)</p> Signup and view all the answers

What type of channels are opened in the muscle fiber membrane during the local depolarization?

<p>Ligand-gated ion channels (B)</p> Signup and view all the answers

What is the primary function of the SNARE proteins in the synaptic vesicles?

<p>To hold synaptic vesicles in place (D)</p> Signup and view all the answers

Which of the following muscle properties is responsible for the ability to return to its original shape after being stretched?

<p>Elasticity (B)</p> Signup and view all the answers

What is the function of the T-tubules in skeletal muscle fibers?

<p>To allow plasma membrane of muscle fiber to carry depolarization of action potential to interior of the fiber (D)</p> Signup and view all the answers

What is the primary function of myoglobin in skeletal muscles?

<p>To serve as a local oxygen reservoir that can temporarily provide oxygen (C)</p> Signup and view all the answers

What is the primary function of the RYR channel in the sarcoplasmic reticulum?

<p>To release a pulse of Ca2+ into the cytosol (B)</p> Signup and view all the answers

What is the effect of Ca2+ binding to troponin?

<p>It causes the tropomyosin to move away from the myosin-binding sites (A)</p> Signup and view all the answers

What is the term for the ability of a muscle to be stimulated by a motor nerve?

<p>Excitability (B)</p> Signup and view all the answers

What is the type of muscle fiber that is rich in mitochondria and relies on oxidative metabolism?

<p>Type 1 (Red Fibers) (B)</p> Signup and view all the answers

What is the significance of the transverse tubules (T-tubules) in muscle contraction?

<p>They help to propagate action potentials to the interior of the cell (D)</p> Signup and view all the answers

What is the role of Na+ channels in the generation of an action potential?

<p>They generate and propagate action potentials (D)</p> Signup and view all the answers

What is the term for the potential difference generated across a membrane when a charged solute (ion) diffuses down its concentration gradient?

<p>Diffusion potential (C)</p> Signup and view all the answers

What is the role of the sarcoplasmic reticulum in skeletal muscle fibers?

<p>To regulate calcium storage and release (D)</p> Signup and view all the answers

What is the result of the binding of ATP to the myosin head?

<p>The myosin head becomes 'cocked' and ready to bind to the actin filament (A)</p> Signup and view all the answers

What is the function of the DHPR in the neuromuscular junction?

<p>To sense membrane depolarization and open the RYR channel (C)</p> Signup and view all the answers

What is the term for the bundle or cluster of muscle fibers that are surrounded by perimysium?

<p>Fascicle (D)</p> Signup and view all the answers

What is the effect of the myosin head bending towards the center of the sarcomeres?

<p>It causes the actin filaments to slide towards the M-line (C)</p> Signup and view all the answers

What is the term for the thin membrane that encloses a skeletal muscle cell?

<p>Sarcolemma (B)</p> Signup and view all the answers

What is the role of the voltage-gated K+ channels in the repolarization of the sarcolemma?

<p>They help to restore the sarcolemma to its initial polarized state (C)</p> Signup and view all the answers

What is the result of the action potential propagating down the T-tubules?

<p>The RYR channel opens briefly (D)</p> Signup and view all the answers

What is the primary function of the Ca 2+ active transport pump?

<p>To remove Ca 2+ ions from the myofibrillar fluid after contraction (C)</p> Signup and view all the answers

What is the term for a single contraction and relaxation cycle produced by an action potential within a muscle fiber?

<p>Twitch (D)</p> Signup and view all the answers

What is the primary source of energy for muscle contraction, accounting for 95% of energy used?

<p>Oxidative Metabolism (D)</p> Signup and view all the answers

What is the term for the phenomenon where successive muscle contractions fuse together at a critical frequency, resulting in a smooth and continuous contraction?

<p>Tetanus (D)</p> Signup and view all the answers

What is the term for the relationship between muscle length and contraction strength?

<p>Length-tension relationship (C)</p> Signup and view all the answers

What is the primary role of creatine phosphokinase in muscle contraction?

<p>To phosphorylate creatine to produce phosphocreatine (D)</p> Signup and view all the answers

What is the term for the decrease in muscle contraction strength that occurs when the muscle is shortened or stretched?

<p>Length-tension relationship (D)</p> Signup and view all the answers

What is the term for the region of the sarcomere where only thick filaments are present?

<p>H zone (D)</p> Signup and view all the answers

What is the term for the contraction of a whole muscle that appears to be completely smooth and continuous due to the rapid fusion of successive muscle twitches?

<p>Tetanus (D)</p> Signup and view all the answers

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