Physiology of Menstruation

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Questions and Answers

What is the role of the basal layer during menstruation?

  • It becomes hypervascularized to increase oxygen supply.
  • It thickens to prepare for pregnancy.
  • It remains intact to support regeneration. (correct)
  • It is shed along with the other layers.

What characterized the luteal phase of the endometrium?

  • Loss of hypoechoic halo. (correct)
  • Hypoechoic endometrium thickness of 1-3 mm.
  • The presence of a triple line sign.
  • Increased activity of the basal layer.

During early menses, what does the endometrial echo resemble?

  • A thick hypoechoic central echo. (correct)
  • Three distinct echogenic lines.
  • A uniform hyperechoic area.
  • A single hyperechoic line.

What does the anteroposterior thickness of the endometrium measure during late menses?

<p>1-3 mm. (D)</p> Signup and view all the answers

Which Greek term is associated with the definition of estrogen?

<p>Oistros. (C)</p> Signup and view all the answers

What happens to the hypoechoic central echo during the late menses phase?

<p>It completely disappears. (A)</p> Signup and view all the answers

Which phase shows the maximum endometrial thickness?

<p>Luteal phase. (A)</p> Signup and view all the answers

What occurs to the endometrial echo during the early follicular phase?

<p>A halo is present. (B)</p> Signup and view all the answers

Which structure is primarily responsible for the secretion of progesterone during pregnancy?

<p>Corpus Luteum (D)</p> Signup and view all the answers

What is the primary hormone present in the bloodstream during the time of ovulation?

<p>Estrogen (C)</p> Signup and view all the answers

Which cell type predominates in the vaginal maturation index during the pre-ovulatory phase?

<p>Superficial cells (D)</p> Signup and view all the answers

What percentage of progesterone is typically protein-bound in the bloodstream?

<p>99% (D)</p> Signup and view all the answers

What causes the shift in the vaginal maturation index towards acidophilic cells?

<p>Increased estrogen levels (A)</p> Signup and view all the answers

What is the primary role of syncytiotrophoblast cells during pregnancy?

<p>Establishment of placental attachment (D)</p> Signup and view all the answers

What happens to the cervical mucous during the progestational phase?

<p>It increases in amount and viscosity (A)</p> Signup and view all the answers

How is most progesterone excreted from the body during pregnancy?

<p>In urine as pregnandiol (A)</p> Signup and view all the answers

What is defined as the absence of menstruation?

<p>Amenorrhea (C)</p> Signup and view all the answers

Which of the following is NOT a physiological cause of amenorrhea?

<p>Hypothyroidism (C)</p> Signup and view all the answers

At what age is primary amenorrhea defined if secondary sexual characteristics are present?

<p>16 years (C)</p> Signup and view all the answers

What best characterizes secondary amenorrhea?

<p>Absence of menstruation for 6 months (B)</p> Signup and view all the answers

Which of the following conditions is associated with cryptomenorrhea?

<p>Structural abnormalities (B)</p> Signup and view all the answers

What component is essential for normal menstruation according to the four-compartment approach?

<p>Healthy uterine cavity (D)</p> Signup and view all the answers

Which of the following indicates primary amenorrhea if no secondary characteristics are present?

<p>By age 14 (A)</p> Signup and view all the answers

Which of the following options is an accurate definition of cryptomenorrhea?

<p>Absence of bleeding despite an intact reproductive system (C)</p> Signup and view all the answers

What is primarily responsible for the cyclic production of hormones that regulate the menstrual cycle?

<p>Ovarian follicles and corpus luteum (C)</p> Signup and view all the answers

Which hormone is secreted by the hypothalamus to control the release of FSH and LH from the pituitary?

<p>Gonadotropin-releasing hormone (B)</p> Signup and view all the answers

Which of the following conditions is considered a disorder of the outflow tract related to primary amenorrhea?

<p>Androgen insensitivity syndrome (B)</p> Signup and view all the answers

What role do the thyroid and adrenal glands play in menstruation?

<p>They provide necessary support hormones. (C)</p> Signup and view all the answers

What is the most common cause of primary amenorrhea listed in the document?

<p>Gonadal dysgenesis (B)</p> Signup and view all the answers

Which hormone primarily promotes follicular development in the ovarian cycle?

<p>Follicle-stimulating hormone (D)</p> Signup and view all the answers

What is the role of luteinizing hormone in the menstrual cycle?

<p>Stimulates ovulation (A)</p> Signup and view all the answers

Which compartment is primarily concerned with the disorders of the ovary that cause primary amenorrhea?

<p>Compartment II (D)</p> Signup and view all the answers

Which syndrome is characterized by the presence of a 45X karyotype?

<p>Turner's syndrome (C)</p> Signup and view all the answers

What condition is associated with androgen insensitivity?

<p>Müllerian agenesis (C)</p> Signup and view all the answers

Which of the following conditions is categorized under disorders of the anterior pituitary?

<p>Hypopituitary states (A)</p> Signup and view all the answers

Which condition does NOT contribute to the dual pathologies leading to amenorrhea?

<p>Frohlich's syndrome (D)</p> Signup and view all the answers

What condition is specifically associated with secondary sexual characteristics being absent?

<p>Turner's syndrome (C)</p> Signup and view all the answers

Which of these would be classified under disorders of the CNS contributing to amenorrhea?

<p>Kallman syndrome (A)</p> Signup and view all the answers

What is the most likely diagnosis if a pelvic ultrasound shows an absent uterus and reduced serum gonadotropin levels?

<p>Müllerian agenesis (C)</p> Signup and view all the answers

Which condition can occur after excessive curettage and may lead to secondary amenorrhea?

<p>Asherman's syndrome (B)</p> Signup and view all the answers

In a case of hypergonadotropic hypogonadism, what laboratory finding is expected?

<p>Increased FSH and LH (A)</p> Signup and view all the answers

What type of obstruction might be evaluated for if there is amenorrhea and a normal uterus is found?

<p>Transverse vaginal septum (A)</p> Signup and view all the answers

What is the most common cause of Asherman's syndrome?

<p>Vigorous postpartum uterine curettage (C)</p> Signup and view all the answers

Which symptom is not typically associated with Sheehan's syndrome?

<p>Increased sensitivity to heat (D)</p> Signup and view all the answers

What is the primary treatment method for Asherman's syndrome?

<p>Hysteroscopic lysis of adhesions (C)</p> Signup and view all the answers

Which condition is characterized by hypogonadotropic hypogonadism and anosmia?

<p>Kallman's syndrome (A)</p> Signup and view all the answers

What happens to the anterior pituitary gland in Sheehan's syndrome?

<p>It experiences ischemic necrosis (C)</p> Signup and view all the answers

What is the prognosis for individuals with amenorrhea caused by Asherman's syndrome?

<p>Poor in cases of amenorrhea (D)</p> Signup and view all the answers

Which hormone levels are typically low in Sheehan's syndrome?

<p>Luteinizing hormone (LH) (D)</p> Signup and view all the answers

What appearance can be seen in hysterosalpingography for diagnosing Asherman's syndrome?

<p>Honey-comb appearance (D)</p> Signup and view all the answers

Flashcards

Secretory phase basilar arteries

Basilar arteries remain straight during the secretory phase, maintaining blood supply to the basal layer of the endometrium.

Endometrial Necrosis

Cell death in endometrial layers, causing tissue shedding.

Menstrual Layer Shedding

Superficial endometrial layers are shed during menstruation because of compromised blood supply affecting other layers.

Early Menses

Early phase of menstruation (days 1-4) characterized by blood, a thick hypoechoic central echo with a hyperechoic endometrial echo and posterior enhancement.

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Late Menses

Late phase of menstruation (days 3-7), featuring a single hyperechoic thin line (central endometrial echo) and a hypoechoic halo.

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Luteal Phase

Phase during menstrual cycle characterized by maximum endometrial thickness, hyperechoic endometrium, loss of halo, and maximum posterior enhancement.

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Early Follicular Phase

Phase of the menstrual cycle (days 5-9) with a halo present, a relatively thin endometrium, and 6mm thickness.

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Estrogen Function

Estrogen, from the Greek "Oistros" (frenzy; heat), is one of the key hormones in the menstrual cycle.

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Progesterone Function

Progesterone, from the Greek "Pro" (in favor), "Gestare" (to bear), is another important hormone influencing the menstrual cycle.

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Pregnancy hormone

A hormone crucial for sustaining a pregnancy in animals, present during the period when only coitus is possible.

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Graafian follicle

A structure that produces a critical hormone for pregnancy.

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Corpus Luteum

A structure that plays a crucial role in maintaining pregnancy

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Syncytiotrophoblast

A component of the placenta that produces hormones during pregnancy.

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Adrenal cortex

A source of a small amount of pregnancy hormone.

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Peripheral adipose tissue

A source of a small amount of pregnancy hormone.

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Stromal cells of the ovary

Another source of pregnancy hormones, found in the ovary.

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Pregnancy Hormone Metabolism

The liver metabolizes the pregnancy hormone and excretes it in the bile and urine as preg-nandiol.

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Pregnancy Hormone Blood Levels

Blood levels show 2 peaks (one before and one after ovulation).

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Vagina Maturation Index

Shifting to a predominance of acidophilic cells with pyknotic nuclei on a clear background during pregnancy.

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Cervix during pregnancy

The cervix's mucous membrane changes from estrogenic to progestational during pregnancy.

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Protein Binding of pregnancy hormone

Pregnancy hormone is mainly bound to proteins in the blood (like SHBG and albumin).

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Menstrual blood source

The endometrium, the lining of the uterus.

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Endometrium

The inner lining of the uterus that thickens and sheds during the menstrual cycle.

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Estrogen and Progesterone

Female sex hormones that regulate the endometrium.

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Ovarian Cycle

Cyclic production of hormones (estrogen and progesterone) by the ovaries.

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FSH (Follicle-Stimulating Hormone)

Pituitary hormone stimulating follicle development in the ovaries.

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LH (Luteinizing Hormone)

Pituitary hormone triggering ovulation and corpus luteum formation.

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GnRH (Gonadotropin-Releasing Hormone)

Hormone from the hypothalamus that controls FSH and LH release.

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Primary Amenorrhea Causes (Compartment I)

Disorders of the outflow tract (e.g., Mullerian agenesis, MRKH).

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Primary Amenorrhea Causes (Compartment II)

Disorders of the ovaries (e.g., gonadal dysgenesis).

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Asherman's Syndrome

A condition caused by intrauterine adhesions preventing endometrial proliferation and menstruation.

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Intrauterine Adhesions

Scar tissue within the uterus.

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Causes of Asherman's Syndrome

Postpartum uterine curettage and severe uterine infections (e.g., tuberculosis).

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Sheehan's Syndrome

Ischemic necrosis of the anterior pituitary, often due to severe postpartum hemorrhage.

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Anterior Pituitary

Part of the pituitary gland affected in Sheehan's syndrome.

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Kallman's Syndrome

Genetic condition causing hypogonadotropic hypogonadism and anosmia.

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Hypogonadotropic Hypogonadism

Reduced production of hormones by the gonads.

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Anosmia

Loss of the sense of smell.

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Hormonal Therapy (for Asherman's Syndrome)

Treatment used to stimulate endometrial regeneration.

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Hysteroscopic Lysis of Adhesions

Surgical procedure to break up intrauterine adhesions.

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Turner Syndrome

A genetic condition (45,X) characterized by the absence or malfunction of one X chromosome, often resulting in a lack of ovarian function.

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Pure Gonadal Dysgenesis

A condition (46,XX) characterized by the absence or underdevelopment of the ovarian structures and/or a complete lack of ovarian function.

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Swyer Syndrome

A condition (46,XY) where the gonads are underdeveloped or absent, leading to the development of female secondary sexual characteristics.

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Savage Syndrome

A condition also known as resistant ovary syndrome, characterized by an inability of ovaries to respond to stimulating hormones.

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Prolactinoma

A tumor in the anterior pituitary that produces prolactin, a hormone that can cause irregular menstruation.

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Craniopharyngioma

A tumor that develops near the pituitary gland, which may impact hormone production.

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Hypogonadotropic hypogonadism

A condition where the pituitary gland doesn't produce enough hormones to stimulate the gonads (ovaries/testes).

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Hypergonadotropic hypogonadism

A condition where the ovaries/testes don't respond to hormones that stimulate them.

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Primary Amenorrhea

Absence of menstruation by age 14 with no development of secondary sexual characteristics or by age 16 with secondary characteristics.

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Secondary Amenorrhea

Absence of menstruation for three or more cycles or for 3-6 months.

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Asherman's Syndrome

Scar tissue in the uterus (endometrium) preventing normal menstrual flow.

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Amenorrhea Definition

Absence of menstruation.

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Primary Amenorrhea

Absence of menstruation by age 16 (with normal secondary sex characteristics) or age 14 (without secondary sex characteristics).

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Secondary Amenorrhea

Absence of menstruation for 6 months or more, or equivalent to 3 missed cycles, in a previously menstruating woman.

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Progesterone

Hormone crucial in maintaining a pregnancy.

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Placenta function

The organ sustaining the developing fetus during pregnancy.

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Physiological Amenorrhea

Normal absence of menstruation, e.g., pregnancy, breastfeeding, pre-puberty, menopause.

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Cryptomenorrhea

Hidden menstruation; periods occur but the flow isn't expelled.

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Study Notes

Physiology of Menstruation

  • The menstrual cycle is a complex series of physiological changes in women
  • The ovarian component aims to produce a mature ovum in each cycle
  • The uterine component prepares the uterine environment for fertilization
  • The cycle involves interaction of the hypothalamus, pituitary, and gonads
  • The entire cycle lasts approximately 28 days, beginning with the first day of menstruation
  • Ovulation occurs around day 14

Menstruation

  • Menstruation is the cyclic shedding of the secretory endometrium
  • Associated with blood loss due to a decline in estrogen and progesterone production.
  • This loss occurs if no pregnancy takes place, caused by degeneration of the corpus luteum

The Ovarian Cycle

  • The ovary undergoes a monthly cycle with three phases: follicular, ovulation, and luteal
  • The follicular phase begins with the first day of menstrual blood flow
  • The hypothalamus releases GnRH, which stimulates the pituitary to release FSH
  • FSH stimulates the growth of 10-20 ovarian follicles
  • Estrogen is secreted from the growing follicles
  • Inhibin is also secreted
  • The follicle most sensitive to FSH becomes the dominant Graafian follicle
  • The Graafian follicle produces increasing amounts of estrogen
  • The estrogen inhibits the growth of other follicles
  • The graafian follicle reaches around 20mm in size
  • Theca cells are stimulated by LH to produce androgens which are then converted to estradiol by granulosa cells. This process is known as steroidogenesis

Ovulation

  • Ovulation occurs within 24-48 hours of the LH surge
  • The follicle ruptures, releasing a secondary oocyte.
  • This happens at mid-cycle (approximately day 14)

Luteal Phase

  • The corpus luteum is formed from the ruptured follicle
  • It produces progesterone and estradiol
  • These hormones maintain the uterine lining for potential implantation
  • If pregnancy does not occur, the corpus luteum degenerates and progesterone levels decrease, leading to menstruation

The Endometrial Cycle

  • The uterus has a cycle governed by ovarian hormones
  • The endometrium (uterine lining) has two layers: functional and basal
  • The functional layer thickens in response to estrogen
  • The three phases of the endometrial cycle include: proliferative, secretory, and menstrual
  • The proliferative phase corresponds to the follicular phase of the ovarian cycle
  • Estrogen causes regeneration and proliferation of the functional endometrial layer
  • The secretory phase occurs after ovulation
  • Progesterone causes the endometrium to become secretory, preparing it for possible implantation
  • The menstrual phase occurs if implantation does not occur, involving the loss of the functional layer due to vasoconstriction of the spiral arteries.

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