Physiology of Blood Functions

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Questions and Answers

What is a potential cause of anaemia related to erythropoiesis?

  • Increased red blood cell lifespan
  • Excessive erythropoietin production
  • Iron deficiency (correct)
  • Hemolysis of red blood cells

Which additional test is recommended to diagnose the underlying cause of anaemia?

  • Complete blood count (CBC)
  • Liver function tests
  • Iron studies (correct)
  • Thyroid function tests

What do elevated troponin levels indicate in a patient presenting with chest pain?

  • Myocardial injury (correct)
  • Peripheral artery disease
  • Respiratory failure
  • A normal heart function

Which test is essential to assess heart function in a patient suspected of having a heart attack?

<p>ECG (A)</p> Signup and view all the answers

What is a common additional test to determine the severity of coronary artery blockage in a heart attack patient?

<p>Coronary angiography (C)</p> Signup and view all the answers

What is one of the primary roles of blood in nutrient transport?

<p>Delivering carbon dioxide to the lungs (C)</p> Signup and view all the answers

Which component of blood is responsible for maintaining pH balance?

<p>Plasma proteins (B)</p> Signup and view all the answers

How does blood contribute to temperature regulation in the body?

<p>By dilating blood vessels in the skin to release heat (A)</p> Signup and view all the answers

What role do white blood cells play in blood?

<p>Defending against infections (D)</p> Signup and view all the answers

Which of the following accurately describes plasma?

<p>It helps maintain blood pressure through its protein content. (B)</p> Signup and view all the answers

What initiates the clotting process when a blood vessel is injured?

<p>Platelets and clotting factors (B)</p> Signup and view all the answers

Which of the following nutrients is NOT transported by blood?

<p>Cellulose (C)</p> Signup and view all the answers

In what way does blood regulate water content in the body?

<p>By redistributing fluids across different compartments (B)</p> Signup and view all the answers

What is the main function of basophils in the immune response?

<p>Releasing enzymes to enhance inflammation (C)</p> Signup and view all the answers

Which blood type is known as the universal recipient in the ABO blood group system?

<p>Group AB (D)</p> Signup and view all the answers

What type of antibodies does Group A blood contain?

<p>Anti-B antibodies (D)</p> Signup and view all the answers

What is indicated by a faster Erythrocyte Sedimentation Rate (ESR)?

<p>Potential infection or inflammation (D)</p> Signup and view all the answers

What is the significance of O RhD Negative blood type in transfusions?

<p>It can safely be donated to any blood type (B)</p> Signup and view all the answers

What does a CRP (C-Reactive Protein) test measure?

<p>Levels of inflammation in the body (A)</p> Signup and view all the answers

Which of the following statements about eosinophils is correct?

<p>They counteract histamine and reduce inflammation (C)</p> Signup and view all the answers

Which blood group has no antigens on red blood cells and contains both anti-A and anti-B antibodies?

<p>Group O (C)</p> Signup and view all the answers

What does an elevated level of troponin in the blood indicate?

<p>Myocardial damage (C)</p> Signup and view all the answers

Which component does a lipid profile primarily assess?

<p>Cholesterol and triglycerides (A)</p> Signup and view all the answers

Why are high levels of LDL cholesterol considered risky?

<p>They are linked to atherosclerosis. (C)</p> Signup and view all the answers

What do abnormal levels in a urea and electrolytes test primarily indicate?

<p>Potential kidney impairment (A)</p> Signup and view all the answers

What is the primary function of thrombopoietin in thrombopoiesis?

<p>Stimulates the production and maturation of megakaryocytes (D)</p> Signup and view all the answers

What is the primary purpose of a Full Blood Count (FBC)?

<p>To diagnose blood cell conditions (A)</p> Signup and view all the answers

How many molecules of haemoglobin does each red blood cell approximately contain?

<p>270 million (A)</p> Signup and view all the answers

In individuals with diabetes, what does the HbA1c test measure?

<p>Long-term blood sugar control (A)</p> Signup and view all the answers

Which type of white blood cell is most associated with combating allergic reactions?

<p>Eosinophils (B)</p> Signup and view all the answers

Which type of haemoglobin is the most common in adults?

<p>HbA (C)</p> Signup and view all the answers

Which blood test is specifically used to assess kidney function?

<p>Urea and electrolytes (A)</p> Signup and view all the answers

What is the function of neutrophils in the immune response?

<p>Engulf and destroy pathogens (A)</p> Signup and view all the answers

What is the function of cytokines in the body?

<p>Coordinate the immune response (C)</p> Signup and view all the answers

What percentage of white blood cells do eosinophils typically account for?

<p>2-4% (B)</p> Signup and view all the answers

Which type of haemoglobin has a higher affinity for oxygen?

<p>HbF (C)</p> Signup and view all the answers

Which of the following best describes the role of granules in neutrophils?

<p>Contain enzymes for breaking down pathogens (D)</p> Signup and view all the answers

What is the primary component of plasma?

<p>90% water (A)</p> Signup and view all the answers

Which type of blood cell is primarily involved in carrying oxygen?

<p>Erythrocytes (B)</p> Signup and view all the answers

What is the role of platelets in the blood?

<p>Blood clotting (A)</p> Signup and view all the answers

Which hormone is primarily responsible for regulating red blood cell production?

<p>Erythropoietin (EPO) (C)</p> Signup and view all the answers

Which pH range is considered normal for blood?

<p>7.35 to 7.45 (C)</p> Signup and view all the answers

What process involves the production of white blood cells?

<p>Leukopoiesis (C)</p> Signup and view all the answers

Which type of cells are involved in the immune response?

<p>Leukocytes (A)</p> Signup and view all the answers

What is the average temperature of blood in the human body?

<p>38°C (C)</p> Signup and view all the answers

Flashcards

Nutrient and Gas Transport

The process where blood carries oxygen from the lungs to the body's tissues and carbon dioxide from the tissues back to the lungs for exhalation.

Hormone Transport

Blood acts as a messenger, carrying hormones produced by endocrine glands to their target organs or cells.

Temperature Regulation

Blood helps maintain a stable body temperature by distributing heat throughout the body. It can expand blood vessels to cool down or constrict them to warm up.

pH Regulation

Blood contains buffer systems that neutralize excess acids or bases, keeping the pH within 7.35-7.45, essential for cell function.

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Immune Response

Blood carries white blood cells (leukocytes) and antibodies that fight infections and foreign invaders.

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Clotting Mechanism

When a blood vessel is injured, blood platelets and clotting factors work together to form a clot, sealing the wound to prevent excessive blood loss.

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Plasma

The liquid portion of blood, making up about 55% of its volume.

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Anaemia

A condition marked by a lower than normal red blood cell count or haemoglobin concentration. Different causes like iron deficiency, chronic illness, or issues with the production of red blood cells (erythropoiesis) can lead to this.

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Erythropoiesis

The process responsible for generating red blood cells within the bone marrow. Regulated by erythropoietin, a hormone produced by the kidneys.

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Troponin Levels

Elevated levels of this protein indicate damage to the heart muscle, often associated with a heart attack.

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Coronary Angiography

A medical procedure that uses a special dye injected into the blood vessels to visualize the blood flow in the heart. It is used to identify blockages in the coronary arteries.

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Echocardiogram

A painless, non-invasive test that uses sound waves to create images of the heart's structure and function. It is useful for assessing the severity of heart damage caused by a heart attack.

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What is troponin?

A protein released into the blood during a heart attack, indicating myocardial damage.

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What is a lipid profile?

A blood test that measures levels of cholesterol and triglycerides to assess cardiovascular disease risk.

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What are urea and electrolytes?

Tests assessing kidney function by measuring waste products like urea and electrolyte levels.

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What is a full blood count (FBC)?

A test that provides overall blood cell information, including red blood cells, white blood cells, and platelets.

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What is HbA1c?

A test measuring average blood glucose levels over 2-3 months, indicating long-term blood sugar control in people with diabetes.

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What is the function of red blood cells?

Red blood cells are responsible for carrying oxygen throughout the body.

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What is hematopoiesis?

The process by which blood cells are produced, primarily in the bone marrow.

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What is the function of white blood cells?

White blood cells are the body's defense against infection.

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What is erythropoiesis?

The production of red blood cells, starting from hematopoietic stem cells in the bone marrow and culminating in the release of mature erythrocytes.

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What is the function of platelets?

Platelets help in blood clotting to stop bleeding.

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What is erythropoietin (EPO)?

A hormone primarily produced by the kidneys that stimulates the bone marrow to produce more red blood cells in response to low oxygen levels (hypoxia).

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What is leukopoiesis?

The production of white blood cells, involving the differentiation of hematopoietic stem cells into various types of leukocytes.

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What are platelets (thrombocytes)?

Small cell fragments that play a crucial role in blood clotting by adhering to damaged vessel walls and forming temporary plugs.

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What are red blood cells (erythrocytes)?

These cells are responsible for carrying oxygen from the lungs to the tissues and returning carbon dioxide from the tissues back to the lungs. They contain hemoglobin, a protein that binds oxygen.

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What are white blood cells (leukocytes)?

These cells are involved in the immune response, protecting the body from infections and foreign invaders. They come in different types, each with a unique function.

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What is the pH of blood?

The pH of blood is slightly alkaline, with a range of 7.35 to 7.45, and is tightly regulated by buffer systems.

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Basophils

A type of white blood cell that plays a key role in allergic reactions and inflammation. They release chemicals like histamine, heparin, and serotonin from their granules to enhance the inflammatory response.

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Eosinophils

A type of white blood cell that helps combat parasitic infections and modulate inflammation. They contain granules with enzymes that counteract histamine, reducing inflammation.

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ABO Blood Group System

A system that classifies blood types based on the presence or absence of specific antigens (A and B) on the surface of red blood cells.

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What is thrombopoiesis?

The process by which platelets are produced in the bone marrow. It involves the differentiation of hematopoietic stem cells into megakaryocytes, which then release cytoplasmic fragments into the bloodstream.

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Blood Type A

Individuals with A antigens on red blood cells and anti-B antibodies in their plasma.

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Blood Type B

Individuals with B antigens on red blood cells and anti-A antibodies in their plasma.

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What is thrombopoietin?

A hormone primarily produced by the liver and kidneys. It stimulates the production and maturation of megakaryocytes, ultimately regulating the production of platelets.

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What are cytokines?

Signaling molecules involved in mediating and regulating immunity, inflammation, and hematopoiesis. They act as messengers between cells, coordinating immune responses and influencing blood cell production.

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Blood Type AB

Individuals with both A and B antigens on red blood cells and no antibodies in their plasma. They can receive blood from all ABO blood types, making them the 'universal recipient' in the ABO system.

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Blood Type O

Individuals with no antigens on red blood cells but have both anti-A and anti-B antibodies in their plasma. They can donate blood to all ABO blood types, making them the 'universal donor' in the ABO system.

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What is hemoglobin?

The protein responsible for oxygen transport in red blood cells. It consists of four polypeptide chains, each with an iron-containing heme group that binds oxygen.

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What are neutrophils?

The most abundant type of white blood cell in the body. They are the first responders to infection and perform phagocytosis, engulfing and destroying pathogens.

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Rh Blood Group System

A system that classifies blood types based on the presence or absence of the RhD antigen on the surface of red blood cells.

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What are eosinophils?

These white blood cells fight parasitic infections and allergic reactions. They account for about 2-4% of white blood cells.

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What is HbA (adult haemoglobin)?

This type of haemoglobin comprises about 97% of the haemoglobin in adults and consists of two alpha and two beta chains.

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What is HbF (fetal haemoglobin)?

This primary haemoglobin during fetal development consists of two alpha and two gamma chains. It has a higher affinity for oxygen than HbA, facilitating oxygen transfer from the mother to the fetus.

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Study Notes

Physiology of Blood

  • Blood is a vital fluid, essential for life.
  • It transports nutrients and gases.
  • It regulates physiological processes.
  • Provides protection against diseases and injury.

Functions of Blood

  • Transport:
    • Carries oxygen from lungs to tissues, and carbon dioxide from tissues to lungs.
    • Delivers nutrients like glucose, amino acids, and fatty acids to cells.
    • Removes waste products from cells for excretion.
    • Transports hormones to target organs.
  • Regulation:
    • Maintains body temperature by absorbing and distributing heat.
      • Blood vessels in skin dilate to release heat in warm conditions.
    • Regulates pH (7.35-7.45) through buffer systems.
    • Regulates electrolyte and water balance across different body compartments.
  • Protection:
    • Contains white blood cells and antibodies to fight infections.
    • Initiates clotting mechanisms to prevent excessive blood loss during injury.
      • Platelets and clotting factors work together to form a clot.

Components of Blood

  • Plasma: Liquid portion (about 55% of blood volume)
    • Primarily water and dissolved proteins (albumin, globulins, fibrinogen).
    • Contains electrolytes, nutrients, waste products, and hormones.
  • Red Blood Cells (Erythrocytes):
    • Carry oxygen from lungs to tissues.
    • Contain hemoglobin (protein that binds oxygen).
  • White Blood Cells (Leukocytes):
    • Protect against infections and foreign invaders.
    • Divided into various types (neutrophils, eosinophils, basophils, monocytes, lymphocytes).
  • Platelets (Thrombocytes):
    • Important role in blood clotting.
    • Form temporary plug at injury sites.

pH and Temperature

  • Blood pH: Ranges from 7.35 to 7.45 (slightly alkaline).
  • Blood temperature: Slightly higher than the body's average temperature (approximately 38°C).

Haematopoiesis

  • Production of blood cells (red blood cells, white blood cells, and platelets).
  • Primarily occurs in bone marrow.

Erythropoiesis

  • Production of red blood cells.
  • Regulated by erythropoietin (EPO), mainly produced by kidneys.
  • EPO stimulates bone marrow to produce more red blood cells, especially in low-oxygen conditions (hypoxia).

Leukopoiesis

  • Production of white blood cells.
  • Involves differentiation of hematopoietic stem cells into various types of leukocytes.
  • Regulated by cytokines (e.g., interleukins, colony-stimulating factors).
    • Promote the differentiation and proliferation of specific leukocyte lineages.

Thrombopoiesis

  • Production of platelets.
  • Involves differentiation of hematopoietic stem cells into megakaryocytes.
  • Megakaryocytes release platelets into bloodstream.
  • Regulated by thrombopoietin (produced by the liver and kidneys).

Red Blood Cells (Erythrocytes)

  • Contain hemoglobin, crucial for oxygen transport.
  • Hemoglobin consists of four polypeptide chains with iron-containing heme groups.
  • Normal red blood cell counts differ by sex, approximately 4.7 to 6.1 million cells per microliter of blood in men.
  • Different types of haemoglobin exist, particularly fetal hemoglobin (HbF), which has a higher oxygen affinity.

White Blood Cells (Leukocytes)

  • Crucial in body's defense mechanisms.
  • Different types with unique roles in immune responses.
    • Neutrophils are the most abundant type, engulfing and destroying pathogens.

Blood Types

  • ABO and Rh systems are important blood group systems.
  • Blood types determined by antigens on red blood cells.
  • Compatibility is crucial for blood transfusions, as incompatible blood types can lead to serious consequences.

Blood Tests

  • Various blood tests used to diagnose conditions and assess overall health.
    • ESR (Erythrocyte Sedimentation Rate) measures inflammation.
    • CRP (C-Reactive Protein) measures inflammation.
    • Troponin for heart attack diagnosis.
    • Lipid Profile (cholesterol and triglycerides) for cardiovascular risk assessment.
    • Urea and electrolytes for kidney function.
    • Full Blood Count (red blood cells, white blood cells, platelets) for various conditions.
    • HbA1c for long-term blood sugar control in diabetes.

Clinical Cases

  • Examples of anemia (low hemoglobin) and potential causes.
  • Elevated troponin levels in heart attack diagnosis.

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