KPE264 Formulas/Calculations

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Questions and Answers

A patient has an end-diastolic volume (EDV) of 120 ml and an end-systolic volume (ESV) of 50 ml. What is the patient's stroke volume?

  • 120 ml
  • 70 ml (correct)
  • 50 ml
  • 170 ml

If a person has a heart rate of 75 beats per minute and a stroke volume of 80 ml, what is their cardiac output?

  • 6000 L/min
  • 6.0 L/min (correct)
  • 0.94 L/min
  • 93.75 L/min

During exercise, if a person's minute ventilation increases from 6 L/min to 18 L/min and their respiratory rate increases from 12 breaths/min to 30 breaths/min, what is the change in their tidal volume?

  • Increases by 0.1 L
  • Decreases by 0.1 L
  • Increases by 0.4 L (correct)
  • No change

Which of the following would cause an increase in resistance to blood flow, assuming all other factors remain constant?

<p>Increased blood viscosity (A)</p> Signup and view all the answers

A patient has a systolic blood pressure of 130 mmHg and a diastolic blood pressure of 80 mmHg. Calculate the Mean Arterial Pressure (MAP).

<p>96.67 mmHg (A)</p> Signup and view all the answers

If a 60-year-old man has a heart rate of 130 bpm during exercise, what percentage of his predicted maximum heart rate is he achieving?

<p>Approximately 85% (C)</p> Signup and view all the answers

What happens to Total Peripheral Resistance (TPR) during exercise, assuming cardiac output increases significantly while Mean Arterial Pressure (MAP) sees a smaller increase?

<p>TPR decreases (D)</p> Signup and view all the answers

If arterial O2 content (CaO2) is 20 ml O2/dL of blood, and venous O2 content (CvO2) is 15 ml O2/dL of blood, what is the arterial-venous O2 difference?

<p>5 ml O2/dL (B)</p> Signup and view all the answers

According to the Fick equation, if VO2 increases and the (a-v)O2 difference remains constant, what must happen to cardiac output (Q)?

<p>Cardiac output must increase. (D)</p> Signup and view all the answers

How would you calculate the rate-pressure product (RPP)?

<p>HR * SBP (D)</p> Signup and view all the answers

What is the formula for calculating minute ventilation?

<p>Tidal Volume x Respiratory Rate (A)</p> Signup and view all the answers

How is alveolar ventilation calculated?

<p>(Tidal volume - Dead space) x Respiratory rate (A)</p> Signup and view all the answers

What is the formula to estimate maximum heart rate?

<p>220 - age (D)</p> Signup and view all the answers

Which formula correctly calculates stroke volume?

<p>End-diastolic volume - End-systolic volume (B)</p> Signup and view all the answers

What determines the arterial-venous oxygen difference?

<p>CaO2 - CvO2 (D)</p> Signup and view all the answers

According to the simplified Fick equation, what is the relationship between VO2, cardiac output (Q), and the a-v O2 difference?

<p>VO2 = Q x (a-v O2 difference) (A)</p> Signup and view all the answers

What is the formula for the Respiratory Exchange Ratio (RER)?

<p>VCO2 / VO2 (C)</p> Signup and view all the answers

What factors determine blood oxygen content (CaO2 or CvO2)?

<p>Hemoglobin, % saturation, 1.34 (C)</p> Signup and view all the answers

How is blood flow related to pressure change and resistance?

<p>Flow = Pressure change / Resistance (D)</p> Signup and view all the answers

What is the formula for calculating Rate Pressure Product?

<p>HR x SBP (C)</p> Signup and view all the answers

If a patient's blood viscosity increases due to dehydration, and assuming all other factors remain constant, what is the expected change in resistance to blood flow?

<p>Resistance will increase linearly with the increase in viscosity. (C)</p> Signup and view all the answers

During high-intensity exercise, if an individual's cardiac output increases by a factor of 5 while their mean arterial pressure (MAP) increases by a factor of 1.5, what is the approximate change in their total peripheral resistance (TPR)?

<p>TPR decreases by a factor of approximately 0.3 (D)</p> Signup and view all the answers

A subject has a minute ventilation of 12 L/min with a respiratory rate of 15 breaths/min. If their anatomical dead space is estimated to be 150 ml, what is their alveolar ventilation?

<p>9.75 L/min (D)</p> Signup and view all the answers

An endurance athlete with a maximum heart rate of 190 bpm, a maximum stroke volume of 110 ml, and an arterial-venous oxygen difference of 16 ml O2/dL, what is the athlete's VO2max?

<p>3.3 L/min (D)</p> Signup and view all the answers

Suppose the number of carbons in a fatty acid is 18. How many turns will occur during beta oxidation for this fatty acid?

<p>8 (C)</p> Signup and view all the answers

Flashcards

Minute Ventilation (VE)

Volume of air breathed in one minute.

Alveolar Ventilation (VA)

Volume of fresh air reaching the alveoli per minute. VA = (Tidal Volume - Dead Space) x Respiratory Rate

HRmax

Maximum heart rate.

Cardiac Output (Q)

Volume of blood pumped by the heart per minute. CO = SV x HR

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Stroke Volume (SV)

Volume of blood ejected from the ventricle per beat. SV = End Diastolic Volume - End Systolic Volume

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a-v O2 difference

Difference in oxygen content between arterial and venous blood.

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Fick Equation

VO2 = Cardiac Output x (a-v O2 difference)

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VO2max

Maximal rate of oxygen consumption during exercise.

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Respiratory Exchange Ratio (RER)

Ratio of carbon dioxide produced to oxygen consumed.

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Mean Arterial Pressure (MAP)

MAP = DBP + 1/3(SBP - DBP)

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Rate-Pressure Product

Calculated by multiplying heart rate by systolic blood pressure. Reflects the oxygen demand of the heart.

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Flow

Pressure change divided by resistance.

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Partial Pressure of O2 (PO2)

Refers to oxygen dissolved in blood.

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Total Peripheral Resistance (TPR)

Equal to the Mean Arterial Pressure divided by Cardiac Output.

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Blood O2 content

Equals Hgb x 1.34 x % saturation.

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Resistance Equation

Resistance = (viscosity × length) / radius^4

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Beta Oxidation Turns

Related to the amount of energy required to process fatty acids

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Pressure

Pressure equals Flow times Resistance

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Study Notes

  • Minute Ventilation (V̇i or V̇E) is the product of Tidal Volume (VT) and Respiratory Rate (RR).
  • Alveolar Ventilation (V̇A) is calculated by Alveolar Ventilation (VA) multiplied by frequency, which equals Tidal Volume (VT) minus Dead Space (VD) multiplied by Respiratory Rate (RR).
  • Maximum Heart Rate (HRmax) is estimated by subtracting age from 220.
  • Cardiac Output (Q) is the product of Heart Rate (HR) and Stroke Volume (SV).
  • Stroke Volume (SV) is calculated by End Diastolic Volume (EDV) minus End Systolic Volume (ESV).
  • Arterial-Venous Oxygen Difference (a-v O2 difference) is the difference between Arterial Oxygen Content (CaO2) and Venous Oxygen Content (CvO2).
  • Fick Equation determines VO2 by multiplying Cardiac Output (Q) by the Arterial-Venous Oxygen Difference (a-v O2 diff).
  • VO2max is calculated by multiplying Maximum Heart Rate (HRmax) by Maximum Stroke Volume (SVmax) and the Arterial-Venous Oxygen Difference (a-v O2 diff).
  • Respiratory Exchange Ratio (RER) is the ratio of Carbon Dioxide production (VCO2) to Oxygen consumption (VO2).
  • The number of turns in Beta Oxidation equals the number of carbons divided by 2, then subtract 1.
  • Partial Pressure of Oxygen (PO2) is determined by multiplying the fraction of Oxygen concentration by the total pressure.
  • Blood Oxygen content (CaO2 or CvO2) is calculated by multiplying Hemoglobin (Hgb) by 1.34 and the percentage of saturation (% sat).
  • Flow is equivalent to the change in pressure divided by resistance.
  • Resistance is determined by the viscosity multiplied by the length, divided by the radius to the power of 4.
  • Pressure is the product of Flow and Resistance.
  • Mean Arterial Pressure (MAP) is calculated by adding Diastolic Blood Pressure (DBP) to one-third of the difference between Systolic Blood Pressure (SBP) and Diastolic Blood Pressure (DBP).
  • Total Peripheral Resistance (TPR) is calculated by dividing Mean Arterial Pressure (MAP) by Cardiac Output (Q).
  • Rate-Pressure Product is the product of Heart Rate (HR) and Systolic Blood Pressure (SBP).

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