Physiology: Cell Membrane Transport

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Questions and Answers

What is the primary function of the leaky K+ channel?

  • To generate graded potentials in response to mechanical vibration
  • To regulate the action potential in neurons
  • To control the resting membrane potential in neurons (correct)
  • To facilitate the movement of glucose into the cell

Which type of channel is involved in the neuromuscular junction?

  • Mechanically gated channel
  • Ligand-gated channel (correct)
  • Voltage-gated channel
  • Channel-mediated molecule

What is the primary function of GLUT4 transporter?

  • To facilitate the movement of ions across the membrane
  • To facilitate the movement of water molecules across the membrane
  • To regulate the movement of glucose into the cell (correct)
  • To generate action potentials in neurons

What happens to a cell when it is placed in a hypertonic solution?

<p>Water moves out of the cell, causing it to crenate (B)</p> Signup and view all the answers

What is the primary function of aquaporin protein channels?

<p>To facilitate the movement of water molecules across the membrane (C)</p> Signup and view all the answers

What type of channel is involved in generating graded potentials in response to mechanical vibration?

<p>Mechanically gated channel (C)</p> Signup and view all the answers

What is the term for the movement of water molecules from a solution with a high concentration of water molecules to a solution with a lower concentration of water molecules?

<p>Osmosis (D)</p> Signup and view all the answers

What happens when a cell is placed in an isotonic solution?

<p>There is no net movement of water into or out of the cell (A)</p> Signup and view all the answers

What is the primary function of the Na-K pump in the Na-glucose secondary transport mechanism?

<p>To generate a high Na gradient across the cell membrane (C)</p> Signup and view all the answers

What is the term for the process by which cells take in external solids?

<p>Phagocytosis (B)</p> Signup and view all the answers

What is the primary function of exocytosis?

<p>To export intracellularly synthesized materials from the cell (B)</p> Signup and view all the answers

What is the mechanism by which cholesterol enters cells?

<p>Receptor-mediated endocytosis (D)</p> Signup and view all the answers

What is the term for the uptake of extracellular fluids and dissolved solutes?

<p>Pinocytosis (A)</p> Signup and view all the answers

What is the function of the glucose-Na symport protein in the Na-glucose secondary transport mechanism?

<p>To transport glucose through the Na gradient into the cell (C)</p> Signup and view all the answers

What happens to the overall concentration of solutes on both sides of the cell membrane when there is no net movement of water particles?

<p>The concentration of solutes on both sides remains constant (D)</p> Signup and view all the answers

What type of solution has a lower solute concentration than another solution?

<p>Hypotonic solution (D)</p> Signup and view all the answers

What happens to the red blood cell in a hypertonic solution?

<p>It appears to shrink (B)</p> Signup and view all the answers

What is the primary function of primary active transport?

<p>To move molecules from lower concentration to higher concentration (A)</p> Signup and view all the answers

What is the Na-K pump an example of?

<p>Primary active transport (B)</p> Signup and view all the answers

What is the result of the Na-K pump's action?

<p>Na+ moves from inside the cell to high concentration outside, and K+ moves in opposite direction (A)</p> Signup and view all the answers

What is the role of ATPase in primary active transport?

<p>To create a conformational change in the membrane protein (C)</p> Signup and view all the answers

What is the effect of insulin and thyroid hormones (T3 and T4) on ATPase enzyme?

<p>They increase ATPase enzyme (D)</p> Signup and view all the answers

What is the primary function of the cell membrane?

<p>To regulate the entry and exit of molecules (C)</p> Signup and view all the answers

What is the direction of movement of particles in passive transfusion?

<p>From an area of greater concentration to an area of lesser concentration (D)</p> Signup and view all the answers

What type of molecules can traverse the cell membrane through simple diffusion?

<p>Small and non-polar molecules (B)</p> Signup and view all the answers

What is the role of proteins in facilitated diffusion?

<p>To mediate diffusion through channels or carriers (C)</p> Signup and view all the answers

Why can't glucose diffuse across the cell membrane?

<p>Because it's a large molecule (D)</p> Signup and view all the answers

What is the purpose of facilitated diffusion?

<p>To facilitate the transfer of substances that cannot cross the membrane through simple diffusion (C)</p> Signup and view all the answers

What is an example of facilitated diffusion?

<p>K+ leaky channel in neurons (B)</p> Signup and view all the answers

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Study Notes

Cell Membrane Transport

  • Cell membrane is a phospholipid bilayer that regulates the entry and exit of molecules
  • Cell transport can be classified into passive and active transport

Passive Transport

  • No energy required
  • Movement of particles from an area of higher concentration to an area of lesser concentration
  • Types of passive transport:
    • Simple diffusion
    • Facilitated diffusion
    • Osmosis

Simple Diffusion

  • Movement of small, non-polar molecules (e.g. O2, CO2, steroids, lipid-soluble drugs) from higher to lower concentration
  • No energy required
  • No protein-mediated transport

Facilitated Diffusion

  • Movement of large or charged molecules (e.g. glucose, amino acids, nucleic acids) from higher to lower concentration
  • Proteins required for transport (channel or carrier proteins)
  • No energy required
  • Types of facilitated diffusion:
    • Leaky channels (e.g. K+ leaky channel in neurons)
    • Voltage-gated channels (e.g. Na+ and Ca++ in neurons)
    • Ligand-gated channels (e.g. acetylcholine in neuromuscular junction)
    • Mechanically gated channels (e.g. sound waves or pressure in sensory receptors)

Osmosis

  • Movement of water molecules from higher to lower concentration
  • Depends on solute concentration (e.g. Na+, glucose)
  • Types of solutions:
    • Hypertonic solution (higher solute concentration)
    • Isotonic solution (equal solute concentration)
    • Hypotonic solution (lower solute concentration)
  • Aquaporin protein channels facilitate water movement

Active Transport

  • Movement of molecules from lower to higher concentration
  • Energy required (typically from ATP hydrolysis)
  • Types of active transport:
    • Primary active transport
    • Secondary active transport

Primary Active Transport

  • Directly uses ATP energy
  • Involves conformational change in membrane protein
  • Examples:
    • Na-K pump (antiport that transfers K+ and Na+ into and out of the cell)
    • CaATPase
    • Proton pump (H+)

Secondary Active Transport

  • Uses energy from primary active transport
  • Examples:
    • Na-glucose secondary transport mechanism (uses Na-K pump to generate Na gradient)
    • Glucose-Na symport protein transports glucose into the cell

Endocytosis

  • Cell membrane wraps around external medium, forming endosomes
  • Types of endocytosis:
    • Pinocytosis (small vesicles with fluid)
    • Phagocytosis (larger vesicles with solids)
    • Receptor-mediated endocytosis (substances bind to specific receptors)

Exocytosis

  • Export of intracellularly synthesized materials from the cell
  • Vesicles fuse with the outer membrane
  • Examples:
    • Cell-specific protein products
    • Neurotransmitters
    • Various other molecules

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