Podcast
Questions and Answers
What is the primary reason why the resting membrane potential of a neuron is different from the potassium equilibrium potential?
What is the primary reason why the resting membrane potential of a neuron is different from the potassium equilibrium potential?
Which statement accurately describes the equilibrium potential for an ion?
Which statement accurately describes the equilibrium potential for an ion?
What is the role of the sodium-potassium pump in maintaining the resting membrane potential?
What is the role of the sodium-potassium pump in maintaining the resting membrane potential?
How does the permeability of the cell membrane to different ions affect the resting membrane potential?
How does the permeability of the cell membrane to different ions affect the resting membrane potential?
Signup and view all the answers
Consider a neuron with a resting membrane potential of -70mV. How would increasing the permeability of the membrane to Na+ affect the resting membrane potential?
Consider a neuron with a resting membrane potential of -70mV. How would increasing the permeability of the membrane to Na+ affect the resting membrane potential?
Signup and view all the answers
If the concentration of K+ outside the cell is increased, how would this affect the potassium equilibrium potential?
If the concentration of K+ outside the cell is increased, how would this affect the potassium equilibrium potential?
Signup and view all the answers
The Goldman equation is used to calculate the resting membrane potential. What makes this equation different from simply calculating the Nernst equation for each ion?
The Goldman equation is used to calculate the resting membrane potential. What makes this equation different from simply calculating the Nernst equation for each ion?
Signup and view all the answers
Which of the following statements about the resting membrane potential is TRUE?
Which of the following statements about the resting membrane potential is TRUE?
Signup and view all the answers
What is the relationship between the viscosity of blood and the viscosity of plasma?
What is the relationship between the viscosity of blood and the viscosity of plasma?
Signup and view all the answers
What is the approximate range of resistivity for the plasma membrane at physiological temperatures?
What is the approximate range of resistivity for the plasma membrane at physiological temperatures?
Signup and view all the answers
Which of these is NOT a factor influencing the viscosity of blood?
Which of these is NOT a factor influencing the viscosity of blood?
Signup and view all the answers
What is the relation between specific resistance (resistivity) and the resistance of a conductor?
What is the relation between specific resistance (resistivity) and the resistance of a conductor?
Signup and view all the answers
Why does the plasma membrane offer a higher resistance than the internal and external fluids?
Why does the plasma membrane offer a higher resistance than the internal and external fluids?
Signup and view all the answers
Which of the following best describes the principle underlying the concept of a dielectric material in relation to a capacitor.
Which of the following best describes the principle underlying the concept of a dielectric material in relation to a capacitor.
Signup and view all the answers
Which of the following is NOT a characteristic of the liquid-crystalline state of the cell membrane, as described in the text?
Which of the following is NOT a characteristic of the liquid-crystalline state of the cell membrane, as described in the text?
Signup and view all the answers
Based on the text, which of these statements about body fluids and their conductivity is CORRECT?
Based on the text, which of these statements about body fluids and their conductivity is CORRECT?
Signup and view all the answers
During the repolarization phase of an action potential, the membrane potential is primarily influenced by the movement of which ion?
During the repolarization phase of an action potential, the membrane potential is primarily influenced by the movement of which ion?
Signup and view all the answers
Which of the following statements accurately describes the role of the sodium-potassium pump in the action potential cycle?
Which of the following statements accurately describes the role of the sodium-potassium pump in the action potential cycle?
Signup and view all the answers
At what point in the action potential cycle is the membrane most permeable to sodium ions?
At what point in the action potential cycle is the membrane most permeable to sodium ions?
Signup and view all the answers
Which of the following is TRUE regarding the absolute refractory period?
Which of the following is TRUE regarding the absolute refractory period?
Signup and view all the answers
What is the main factor that determines the firing level or threshold of an action potential?
What is the main factor that determines the firing level or threshold of an action potential?
Signup and view all the answers
The standard waveform of an action potential is a graphical representation of what?
The standard waveform of an action potential is a graphical representation of what?
Signup and view all the answers
What is the significance of the sodium-potassium pump in maintaining the resting potential?
What is the significance of the sodium-potassium pump in maintaining the resting potential?
Signup and view all the answers
During the relative refractory period, it is possible for another action potential to be generated, but under what specific condition?
During the relative refractory period, it is possible for another action potential to be generated, but under what specific condition?
Signup and view all the answers
What is the value of the membrane potential, $V_m$, calculated using the Goldman equation, given the following concentrations and permeabilities?| Ion | Concentration (Inside) | Concentration (Outside) | Permeability |---|---|---|---| | K+ | 145 | 5 | 60 | | Na+ | 10 | 140 | 1 |
What is the value of the membrane potential, $V_m$, calculated using the Goldman equation, given the following concentrations and permeabilities?| Ion | Concentration (Inside) | Concentration (Outside) | Permeability |---|---|---|---| | K+ | 145 | 5 | 60 | | Na+ | 10 | 140 | 1 |
Signup and view all the answers
What is the approximate value of $RT/F$ at human body temperature (37 °C)?
What is the approximate value of $RT/F$ at human body temperature (37 °C)?
Signup and view all the answers
Which of these statements is true about the relationship between stimulus intensity and action potential size?
Which of these statements is true about the relationship between stimulus intensity and action potential size?
Signup and view all the answers
What is the term used for a change in the membrane potential that cannot spread far from the site of stimulation?
What is the term used for a change in the membrane potential that cannot spread far from the site of stimulation?
Signup and view all the answers
What is the term used for the state of the cell membrane with a positive charge on the outside and a negative charge on the inside?
What is the term used for the state of the cell membrane with a positive charge on the outside and a negative charge on the inside?
Signup and view all the answers
What is the threshold value that is required for the excitation of a nerve or muscle cell to exceed and generate an action potential?
What is the threshold value that is required for the excitation of a nerve or muscle cell to exceed and generate an action potential?
Signup and view all the answers
What are the main types of stimuli?
What are the main types of stimuli?
Signup and view all the answers
Considering examples of internal and external stimuli - which one of these will be considered an internal stimulus?
Considering examples of internal and external stimuli - which one of these will be considered an internal stimulus?
Signup and view all the answers
What is the primary factor responsible for maintaining the high capacitance of the cell membrane?
What is the primary factor responsible for maintaining the high capacitance of the cell membrane?
Signup and view all the answers
Which of the following best describes the role of ion pumps in cell polarization?
Which of the following best describes the role of ion pumps in cell polarization?
Signup and view all the answers
What is the primary reason why the cell membrane is considered an imperfect dielectric?
What is the primary reason why the cell membrane is considered an imperfect dielectric?
Signup and view all the answers
What is the consequence of the low conductivity of the cell membrane?
What is the consequence of the low conductivity of the cell membrane?
Signup and view all the answers
How does the capacitance per unit area of the cell membrane compare to a typical capacitor?
How does the capacitance per unit area of the cell membrane compare to a typical capacitor?
Signup and view all the answers
Which of the following scenarios would most likely lead to a decrease in the capacitance of the cell membrane?
Which of the following scenarios would most likely lead to a decrease in the capacitance of the cell membrane?
Signup and view all the answers
What is the significance of the intracellular and extracellular fluids being electrolytes?
What is the significance of the intracellular and extracellular fluids being electrolytes?
Signup and view all the answers
Which of the following statements correctly describes the role of active membrane transport in maintaining cell polarization?
Which of the following statements correctly describes the role of active membrane transport in maintaining cell polarization?
Signup and view all the answers
Why does the concentration gradient for K+ facilitate its movement out of the cell via K+ channels?
Why does the concentration gradient for K+ facilitate its movement out of the cell via K+ channels?
Signup and view all the answers
What is the primary reason for the establishment of a resting membrane potential?
What is the primary reason for the establishment of a resting membrane potential?
Signup and view all the answers
Why are leak channels considered important for maintaining the resting membrane potential?
Why are leak channels considered important for maintaining the resting membrane potential?
Signup and view all the answers
How does the sodium-potassium pump contribute to the resting membrane potential?
How does the sodium-potassium pump contribute to the resting membrane potential?
Signup and view all the answers
Which of the following is NOT a condition required for establishing potentials across cell membranes?
Which of the following is NOT a condition required for establishing potentials across cell membranes?
Signup and view all the answers
How is the resting membrane potential (RMP) determined?
How is the resting membrane potential (RMP) determined?
Signup and view all the answers
Which of the following is NOT a function of the sodium-potassium pump in establishing the resting membrane potential?
Which of the following is NOT a function of the sodium-potassium pump in establishing the resting membrane potential?
Signup and view all the answers
Which of the following scenarios would directly contribute to a more negative resting membrane potential?
Which of the following scenarios would directly contribute to a more negative resting membrane potential?
Signup and view all the answers
Flashcards
Dielectric constant
Dielectric constant
A measure of a material's ability to store electric energy in an electric field.
Capacitance
Capacitance
The ability of a capacitor to store electric charge, measured in microfarads (µF).
Capacitor structure
Capacitor structure
Consists of two conducting plates separated by an insulator (dielectric).
Membrane capacitance
Membrane capacitance
Signup and view all the flashcards
Ion pumps
Ion pumps
Signup and view all the flashcards
Cell polarization
Cell polarization
Signup and view all the flashcards
Dielectric loss
Dielectric loss
Signup and view all the flashcards
Electrolyte solutions
Electrolyte solutions
Signup and view all the flashcards
Membrane Viscosity
Membrane Viscosity
Signup and view all the flashcards
Blood Viscosity
Blood Viscosity
Signup and view all the flashcards
Ohm's Law
Ohm's Law
Signup and view all the flashcards
Resistance (R)
Resistance (R)
Signup and view all the flashcards
Conductors
Conductors
Signup and view all the flashcards
Insulators
Insulators
Signup and view all the flashcards
Dielectric
Dielectric
Signup and view all the flashcards
Lipid Matrix
Lipid Matrix
Signup and view all the flashcards
Ideal Gas Constant (R)
Ideal Gas Constant (R)
Signup and view all the flashcards
Membrane Potential (V_m)
Membrane Potential (V_m)
Signup and view all the flashcards
Goldman Equation
Goldman Equation
Signup and view all the flashcards
External Stimulus
External Stimulus
Signup and view all the flashcards
Internal Stimulus
Internal Stimulus
Signup and view all the flashcards
Action Potential
Action Potential
Signup and view all the flashcards
Threshold Value
Threshold Value
Signup and view all the flashcards
Graded Potential
Graded Potential
Signup and view all the flashcards
Cell Membrane Permeability
Cell Membrane Permeability
Signup and view all the flashcards
Conditions for Membrane Potential
Conditions for Membrane Potential
Signup and view all the flashcards
Concentration Gradient
Concentration Gradient
Signup and view all the flashcards
Leak Channels
Leak Channels
Signup and view all the flashcards
Potassium Channels
Potassium Channels
Signup and view all the flashcards
Resting Membrane Potential
Resting Membrane Potential
Signup and view all the flashcards
Na+-K+ Pump
Na+-K+ Pump
Signup and view all the flashcards
Equilibrium of K+
Equilibrium of K+
Signup and view all the flashcards
K+ movement and equilibrium
K+ movement and equilibrium
Signup and view all the flashcards
Charge imbalance
Charge imbalance
Signup and view all the flashcards
Electrical vs. chemical force
Electrical vs. chemical force
Signup and view all the flashcards
Equilibrium potential
Equilibrium potential
Signup and view all the flashcards
Sodium equilibrium potential
Sodium equilibrium potential
Signup and view all the flashcards
Sodium-potassium pump
Sodium-potassium pump
Signup and view all the flashcards
Depolarization Phase
Depolarization Phase
Signup and view all the flashcards
Repolarization Phase
Repolarization Phase
Signup and view all the flashcards
Resting Potential
Resting Potential
Signup and view all the flashcards
Absolute Refractory Period
Absolute Refractory Period
Signup and view all the flashcards
Relative Refractory Period
Relative Refractory Period
Signup and view all the flashcards
Firing Level (Threshold)
Firing Level (Threshold)
Signup and view all the flashcards
Study Notes
Physics of Biological Membrane
- Electrolytes are inorganic compounds often needing water for ionization (molecule splitting). Dissolved compounds in liquid (water) break down into ions (atoms with extra or fewer electrons). Solid NaCl dissolved in water forms Na+ and Cl- ions, thus creating an electrolyte solution. Ions in an electrolyte solution are generally more mobile than in solids.
- Living tissue acts as an electrolytic conductor with both intracellular and extracellular fluids containing mobile ions.
- Electrolyte solutions have positive and negative ions. If electrodes with a potential difference are introduced, positive ions move toward the cathode and negative ions toward the anode. This ion movement creates an electric current through the electrolyte solution.
Electrical Properties of Cell Membrane
- Cell membranes are crucial for separating the cell interior from its surroundings. They are a bi-layered lipid membrane with channels, ion pumps, and other embedded proteins.
- Membrane viscosity is constant when temperature and density remain unchanged. Fluids with small molecules (like air or water) have lower viscosity than blood.
- Blood viscosity varies with temperature. At 37°C, blood viscosity ranges from 3x10⁻³ to 4x10⁻³ Pa-s.
- Materials with very low resistance to current flow are called conductors, and those with high resistance are insulators.
- In bodily fluids, salts and other molecules dissociate into positive and negative ions, making them relatively good conductors of electricity, although not as conductive as metals.
- The internal fluid has higher resistivity than external fluids due to lower volume, narrow cross-sectional area, and plasma membrane resistance.
Dielectric
- A dielectric is an insulating material preventing charge movement between conductive plates within a capacitor.
- Perfect dielectrics have no free charges, reducing electric field intensity between the plates. A high dielectric constant enhances the capacitor's capacitance.
- Cell membranes act like dielectrics, having a high capacitance due to their thinness, and despite their conductivity being low.
Capacitance
- Capacitors store electric charges; the simplest form consists of two conducting plates separated by a dielectric.
- In cells, intracellular and extracellular fluids act as conducting plates, and the cell membrane is the dielectric, resulting in significant capacitance.
- Membrane capacitance is high due to the thin cell membrane (7 nm), high dielectric constant (3-10), and large surface area of the conductive fluids, although ions can diffuse across, affecting dielectric loss.
Cell Polarization (Resting State)
- Cell polarization happens due to ion pumps that move ions against electrochemical gradients.
- Excitation in nerve or muscle cells leads to a membrane potential of roughly -90 mV relative to the extracellular fluid.
- The Na+-K+ pump maintains this membrane potential by pumping 3 Na+ ions out and 2 K+ ions in for each cycle.
- The cell membrane is fairly permeable to potassium ions (K+), less permeable to sodium ions (Na+), and quite permeable to chloride ions (Cl⁻).
Concentration Gradient
- In neurons, K+ and organic anions are highly concentrated inside the cell, whereas Na+ and Cl⁻ are higher outside.
- These concentration gradients across the membrane are vital for establishing membrane potential.
Types of Channels
- Leak channels are always open in resting neurons, allowing ion flow. Ion channels' selectivity varies; some let various ions pass, others are highly selective.
- Potassium channels mostly allow potassium ions to pass, and sodium channels mostly allow sodium ions.
- Differences in ion concentrations and permeabilities are crucial in establishing the cell's resting membrane potential.
Resting Membrane Potential
-
Resting membrane potential is caused by the unequal distribution of ions across the cell membrane and the different permeability of the membrane to various ions.
-
The concentration gradient for potassium and its corresponding electrical gradient are balanced to create an equilibrium potential.
-
The relative permeability of the membrane to different ions affects this equilibrium state of the resting potential.
-
The Goldman equation calculates membrane potential, considering ion concentrations and relative permeabilities (of ions).
Action Potential
- The action potential occurs when a stimulus raises the membrane potential above a threshold, causing a sequence of rapid changes.
- The membrane potential transiently reverses from negative to positive (+40 mV) during depolarization due to rapid Na⁺ influx, followed by repolarization due to K⁺ efflux.
- Na⁺ and K⁺ channels opening and closing, and the active transport mechanism (Na⁺-K⁺ pump) control the process.
Local Response
- Local response is a change in membrane potential that occurs as a result of stimulation, but it does not spread far from its source.
- It's not strong enough to cause a full action potential.
Latent Period
- The latent period is the time between the stimulus and the start of the action potential; it's the time the impulse takes to travel length of the nerve fiber.
Refractory Period
- The refractory period is the time after an action potential where the neuron cannot generate another action potential immediately, preventing repetitive firing.
- Periods include absolute refractory period (cannot produce any stimulus), while relative refractory period requires a strong stimulus.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
This quiz explores the principles behind the physics of biological membranes, focusing on electrolyte solutions and the electrical properties of cell membranes. You'll learn how ions behave in these solutions and how cell membranes play a critical role in separating cellular environments. Test your knowledge of these essential concepts.