Podcast
Questions and Answers
Which type of kinases phophorylate tyrosine residues on target proteins?
Which type of kinases phophorylate tyrosine residues on target proteins?
- Binary kinases
- S/T kinases
- Cytokine kinases
- Y kinases (correct)
How common is tyrosine phosphorylation compared to serine and threonine phosphorylation?
How common is tyrosine phosphorylation compared to serine and threonine phosphorylation?
- More common
- Equally common
- Much less common (correct)
- Rarely happens
What percentage of the genome do tyrosine kinases represent?
What percentage of the genome do tyrosine kinases represent?
- 0.3% (correct)
- 30%
- 2%
- 90%
Which type of pockets in kinases determine specificity based on their depth?
Which type of pockets in kinases determine specificity based on their depth?
What distinguishes True receptor tyrosine kinases from Receptors linked to tyrosine kinases?
What distinguishes True receptor tyrosine kinases from Receptors linked to tyrosine kinases?
What role do oncogenes play in cancer development?
What role do oncogenes play in cancer development?
What percentage of cellular proteins are modified by phosphorylation?
What percentage of cellular proteins are modified by phosphorylation?
What is the primary function of protein phosphatases?
What is the primary function of protein phosphatases?
What is the result of phosphorylation on protein activity?
What is the result of phosphorylation on protein activity?
What is the role of kinases in phosphorylation?
What is the role of kinases in phosphorylation?
What is phosphorylation crucial for regulating?
What is phosphorylation crucial for regulating?
What is the result of rapid turnover in phosphorylation?
What is the result of rapid turnover in phosphorylation?
What happens when the tight regulatory control of RTKs is lost?
What happens when the tight regulatory control of RTKs is lost?
How is the insulin receptor (INS-R) activated?
How is the insulin receptor (INS-R) activated?
What is the outcome of tyrosine kinase activation in INS-R signaling?
What is the outcome of tyrosine kinase activation in INS-R signaling?
Which family of RTKs includes EGFR?
Which family of RTKs includes EGFR?
What action is associated with the HER2/ErbB2 receptor?
What action is associated with the HER2/ErbB2 receptor?
What could be a possible consequence of dysregulated EGFR/HER/ERBB signaling?
What could be a possible consequence of dysregulated EGFR/HER/ERBB signaling?
Which of the following best describes the primary function of the extracellular domain in RTKs?
Which of the following best describes the primary function of the extracellular domain in RTKs?
What is the primary cause of the high basal kinase activity in mutated or overexpressed RTKs in human cancers?
What is the primary cause of the high basal kinase activity in mutated or overexpressed RTKs in human cancers?
In the context of RTK activation, what is the primary role of tyrosine residues in intracellular regulatory regions?
In the context of RTK activation, what is the primary role of tyrosine residues in intracellular regulatory regions?
What are the typical ligands responsible for activating RTKs?
What are the typical ligands responsible for activating RTKs?
What is the main outcome of ligand-induced dimerization of RTKs?
What is the main outcome of ligand-induced dimerization of RTKs?
Which of the following is NOT a common example of RTK ligands?
Which of the following is NOT a common example of RTK ligands?
What is the primary mechanism by which tyrosine kinase-linked receptors are activated?
What is the primary mechanism by which tyrosine kinase-linked receptors are activated?
Which of the following is not a substrate of RTKs?
Which of the following is not a substrate of RTKs?
Which of the following protein-protein interaction domains does not mediate RTK-substrate interactions?
Which of the following protein-protein interaction domains does not mediate RTK-substrate interactions?
Which of the following is not a common feature of GF/cytokine receptors that lack an intrinsic kinase domain?
Which of the following is not a common feature of GF/cytokine receptors that lack an intrinsic kinase domain?
What is the role of the tyrosine kinase domain in RTK activation?
What is the role of the tyrosine kinase domain in RTK activation?
Which of the following is not a type of substrate of RTKs?
Which of the following is not a type of substrate of RTKs?
