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Questions and Answers
What is the drug class of Phentermine?
What is the drug class of Phentermine?
What is the route of administration for Phentermine?
What is the route of administration for Phentermine?
Oral
The recommended dosage for simple obesity is ____ mg daily before breakfast or 1 to 2 hours after breakfast.
The recommended dosage for simple obesity is ____ mg daily before breakfast or 1 to 2 hours after breakfast.
37.5
What are some contraindications for Phentermine?
What are some contraindications for Phentermine?
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Which of the following is a precaution when using Phentermine?
Which of the following is a precaution when using Phentermine?
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Which of the following are common adverse effects of Phentermine?
Which of the following are common adverse effects of Phentermine?
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Phentermine can interact with other medications such as ____ and alcohol.
Phentermine can interact with other medications such as ____ and alcohol.
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Phentermine should be administered without regard to meals.
Phentermine should be administered without regard to meals.
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What does the monitoring of Phentermine use involve?
What does the monitoring of Phentermine use involve?
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What is the mechanism of action (MOA) of Phentermine?
What is the mechanism of action (MOA) of Phentermine?
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What is the renal excretion rate for Phentermine?
What is the renal excretion rate for Phentermine?
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What should patients avoid when taking Phentermine?
What should patients avoid when taking Phentermine?
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Study Notes
Drug Class
- Phentermine is classified as an amphetamine and an anti-obesity agent.
Route of Administration
- Administered orally, either as tablets, capsules, or disintegrating tablets.
Dosing Information
- Recommended dosage varies:
- Tablets: 37.5 mg once daily before or 1-2 hours after breakfast; some may need only 18.75 mg daily or split doses.
- Capsules: 15-30 mg daily, taken 2 hours after breakfast.
- Disintegrating tablets: 15-30 mg dissolved on the tongue in the morning with or without food.
- Discontinue if tolerance develops; do not exceed recommended doses.
Administration Guidelines
- Tablets: Take before breakfast or 1-2 hours after.
- Capsules: Take 2 hours after breakfast.
- Disintegrating tablets: Must be placed on the tongue to dissolve and can be taken with or without water.
- Avoid administration in the late evening to prevent insomnia.
Contraindications
- Should not be taken by individuals with:
- Agitated states
- Cardiovascular diseases
- History of drug abuse
- Glaucoma
- Hyperthyroidism
- Hypersensitivity to sympathomimetics
- Pregnant or nursing women
Precautions
- Avoid combination with other weight loss drugs or SSRIs.
- Monitor diabetes patients as insulin requirements may decrease.
- Report any symptoms of primary pulmonary hypertension.
- Sensitivity to tartrazine (FD&C Yellow No. 5) may occur, particularly with aspirin sensitivity.
Adverse Effects
- Common side effects include:
- Xerostomia (dry mouth)
- Nervousness, insomnia, irritability
- Serious potential effects encompass:
- Cardiomyopathy, heart valve disorders
- Cerebral hemorrhage, ischemia
- Psychotic disorders, and primary pulmonary hypertension
Drug Interactions
- Significant interactions with:
- Isoproterenol, dopamine, ephedrine, epinephrine, norepinephrine
- Linezolid, phenylephrine, venlafaxine
- May interact with other stimulants and medications for obesity.
Monitoring Requirements
- Track weight reduction as an indicator of medication effectiveness.
- Assess renal function, especially in elderly patients or those with renal impairment.
Mechanism of Action
- Phentermine functions as a sympathomimetic amine, stimulating the central nervous system and potentially increasing blood pressure.
- Exact actions related to obesity treatment remain unclear.
Pharmacokinetics
- Absorption properties show a Tmax of 3 to 4.4 hours for orally disintegrating tablets.
- Food can slightly decrease Cmax and AUC.
- Renal excretion is significant, with 62 to 85% excreted unchanged.
Medication Counseling
- Advise against taking phentermine during or within 14 days post-MAO inhibitor use.
- Caution advised regarding activities requiring mental alertness.
- Common side effects include dry mouth, gastrointestinal issues, headache, insomnia, and possible changes in libido.
- Encourage reporting of any declining exercise tolerance or significant side effects.
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Description
This quiz covers the classification, administration, and dosing information for Phentermine, an anti-obesity medication. It outlines the recommended dosages for various forms and provides important guidelines for safe administration. Additionally, the quiz highlights contraindications for users.
