Phases of Drug Development Overview
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Questions and Answers

What is the primary objective of the drug discovery phase?

  • To identify lead molecules (correct)
  • To conduct animal studies
  • To obtain marketing authorisation
  • To know the key phases of drug discovery and development

What impeded the development of back ups when the lead failed in the historical approach to drug discovery?

  • Lack of structural diversity in lead molecules (correct)
  • Unknown mechanisms of active molecules
  • Toxicity of lead molecules
  • Poor pharmacokinetics of lead molecules

How did pharmaceutical industries' success in drug discovery originate in the 1950s and 1960s?

  • Through accidental discovery and chance (correct)
  • By optimizing lead molecules
  • Through rational structure-based approaches
  • By conducting human studies

What was a major limitation of the historical approach to drug discovery in the 20th century?

<p>Lack of molecules with high structural diversity (B)</p> Signup and view all the answers

What did William Withering discover in 1776 through one of his dying patients?

<p>The use of foxglove to treat dropsy or edema (D)</p> Signup and view all the answers

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