Pharmacy: Solubility and Solutions

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What is the primary reason for determining the solubility of a drug in pharmacy practice?

To establish the purity of the drug
To determine the quantitative definition of solubility
To identify the state of subdivision of the solute
To choose the best solvent medium for the drug (correct)

What is the term for a solution that contains the maximum amount of solute that the solvent can hold at a given temperature?

Homogeneous solution
Unsaturated solution
Supersaturated solution
Saturated solution (correct)

What is the unit of measurement for solubility as defined by the USP and NF?

Number of mL of solvent in which 1 mL of solute will dissolve
Number of grams of solvent in which 1 mL of solute will dissolve
Number of mL of solvent in which 1 g of solute will dissolve (correct)
Number of grams of solute in 1 mL of solvent

What is the term for a solution that contains more solute than it can hold at a given temperature?

Supersaturated solution (C) Signup and view all the answers

What is the qualitative definition of solubility?

The spontaneous interaction of 2 or more substances to form a homogeneous molecular dispersion (A) Signup and view all the answers

What is the approximate solubility term for a substance that dissolves in 18 ml of water?

Freely soluble (D) Signup and view all the answers

What is the equivalent weight of HNO3?

63 (A) Signup and view all the answers

What is the normality of a solution made by dissolving 8.5 g of H2SO4 in enough water to make 500 ml solution?

0.34 (C) Signup and view all the answers

What is the ratio of solute to solvent in a saturated solution that contains 100 g of solute and 300 g of solvent?

1:3 (A) Signup and view all the answers

What is the relationship between the normality and molarity of a solution?

The normality is never less than the molarity (D) Signup and view all the answers

What is the normality of a 3 M H2SO4 solution?

6 N (B) Signup and view all the answers

If 100 g of a saturated aqueous solution leaves a residue of 25 g after evaporation, what is the solubility of the anhydrous chemical?

1:3 (B) Signup and view all the answers

What is the normality of a 0.01 M H2SO4 solution?

0.02 N (C) Signup and view all the answers

What is the weight of 100 mL of a saturated aqueous solution with a specific gravity of 1.15?

115 g (B) Signup and view all the answers

If a saturated aqueous solution has a strength of 20% (w/w), what is the solubility of the active ingredient?

1:4 (B) Signup and view all the answers

What is the amount of solvent in a saturated solution that contains 25 g of solute and has a solubility of 1:3.6?

90 g (B) Signup and view all the answers

What is the solubility of a substance if 100 mL of a saturated aqueous solution contains 25 g of the substance?

1:3.6 (B) Signup and view all the answers

What is the solubility of boric acid in water?

1 g in 4 g of water (A) Signup and view all the answers

What is the percentage strength (w/w) of a saturated aqueous solution of boric acid?

5.26% (A) Signup and view all the answers

What is the molar weight of Benzoic acid?

122 dalton (D) Signup and view all the answers

What is the purpose of adding phenolphthalein indicator in the procedure?

To detect the end point of the titration (D) Signup and view all the answers

What is the equivalent weight of salicylic acid in terms of 0.1 N NaOH?

0.0138 gm (D) Signup and view all the answers

What is the formula to calculate the solubility (%) of an acid?

mls of titrant X F X 20 (B) Signup and view all the answers