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Questions and Answers
Non-sterile compounding is addressed in which chapter of the USP?
Non-sterile compounding is addressed in which chapter of the USP?
Chapter 9
Compounding is the on-demand formulation of a drug preparation according to a physician's prescription for?
Compounding is the on-demand formulation of a drug preparation according to a physician's prescription for?
An individual patient
A drug package states, 'Store at 25°C'. Where should the product be stored?
A drug package states, 'Store at 25°C'. Where should the product be stored?
At room temperature
What is the correct temperature for refrigerated products?
What is the correct temperature for refrigerated products?
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Which osteoporosis medication should be stored in the refrigerator?
Which osteoporosis medication should be stored in the refrigerator?
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The documentation that provides the actual ingredients and procedures used to compound a preparation is the?
The documentation that provides the actual ingredients and procedures used to compound a preparation is the?
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What factor affects the beyond-use date of a compound preparation?
What factor affects the beyond-use date of a compound preparation?
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In the absence of other stability data, water-containing formulations from ingredients in solid form should be assigned a beyond-use date that is?
In the absence of other stability data, water-containing formulations from ingredients in solid form should be assigned a beyond-use date that is?
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What would be the latest possible beyond-use date for a non-aqueous medication prepared on February 3, 2017?
What would be the latest possible beyond-use date for a non-aqueous medication prepared on February 3, 2017?
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For a medication to be within the 5% margin of error permitted by the USP, the minimum amount of drug that can be weighed on a class A prescription balance is?
For a medication to be within the 5% margin of error permitted by the USP, the minimum amount of drug that can be weighed on a class A prescription balance is?
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Which is the correct statement when weighing a powder on a class A/Class III torsion balance?
Which is the correct statement when weighing a powder on a class A/Class III torsion balance?
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How often must a Class A prescription balance be certified?
How often must a Class A prescription balance be certified?
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What is the required sensitivity of a class A prescription torsion balance in order to remain within the 5% margin of error?
What is the required sensitivity of a class A prescription torsion balance in order to remain within the 5% margin of error?
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What is the maximum weighable quantity when using a class A prescription balance?
What is the maximum weighable quantity when using a class A prescription balance?
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You need to measure 78 mL of liquid. The proper size graduated cylinder to use is?
You need to measure 78 mL of liquid. The proper size graduated cylinder to use is?
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A 100 mL graduated cylinder cannot accurately measure volume less than?
A 100 mL graduated cylinder cannot accurately measure volume less than?
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Which part of the meniscus should a pharmacy technician use to measure the liquid in the graduated cylinder?
Which part of the meniscus should a pharmacy technician use to measure the liquid in the graduated cylinder?
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Which of the following will cause the phenomenon known as a meniscus?
Which of the following will cause the phenomenon known as a meniscus?
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What technique is used to mix two ingredients of unequal quantities?
What technique is used to mix two ingredients of unequal quantities?
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What type of spatula should be used when measuring corrosive ingredients?
What type of spatula should be used when measuring corrosive ingredients?
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Which is not a method for reducing particle size of a drug?
Which is not a method for reducing particle size of a drug?
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___________________ is the term for triturating a powder with a solvent in which it is insoluble to reduce particle size.
___________________ is the term for triturating a powder with a solvent in which it is insoluble to reduce particle size.
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The fine grinding of a powder is called?
The fine grinding of a powder is called?
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Which of the following is the process of reducing the particle size of a powder by grinding it with a liquid in which it is not soluble?
Which of the following is the process of reducing the particle size of a powder by grinding it with a liquid in which it is not soluble?
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What type of agent increases the viscosity of a suspension?
What type of agent increases the viscosity of a suspension?
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Which of the following are qualities of a well-made suspension?
Which of the following are qualities of a well-made suspension?
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Which of the following liquid dosage forms consists of solid particles dispersed throughout, but not dissolved in liquid?
Which of the following liquid dosage forms consists of solid particles dispersed throughout, but not dissolved in liquid?
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When water is added to a powdered drug, e.g., an antibiotic for a child, the process is called?
When water is added to a powdered drug, e.g., an antibiotic for a child, the process is called?
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This topical dosage form can be made using the dry-gum method, wet-gum method or beaker method.
This topical dosage form can be made using the dry-gum method, wet-gum method or beaker method.
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If you need to compound a liquid preparation containing a water-based vehicle and an active drug that is an oil, the appropriate dosage form would be?
If you need to compound a liquid preparation containing a water-based vehicle and an active drug that is an oil, the appropriate dosage form would be?
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Which dosage form is prepared by compression or molding?
Which dosage form is prepared by compression or molding?
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Capsules can contain?
Capsules can contain?
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Which carbohydrate is often used as a bulk filler in molded tablet triturates?
Which carbohydrate is often used as a bulk filler in molded tablet triturates?
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Which of the following equipment is not used in non-sterile compounding?
Which of the following equipment is not used in non-sterile compounding?
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Pharmacy personnel use various techniques when compounding non-sterile products. Which of the following describes levigation?
Pharmacy personnel use various techniques when compounding non-sterile products. Which of the following describes levigation?
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In the absence of other stability information, what is the appropriate beyond-use date (BUD) for an oral solution prepared with water?
In the absence of other stability information, what is the appropriate beyond-use date (BUD) for an oral solution prepared with water?
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The process of dissolving a powdered drug with a diluent such as water is known as?
The process of dissolving a powdered drug with a diluent such as water is known as?
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Which of the following units are used when interpreting an expression of percentage?
Which of the following units are used when interpreting an expression of percentage?
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Which of the following pieces of equipment must be zeroed out, or recalibrated before each use?
Which of the following pieces of equipment must be zeroed out, or recalibrated before each use?
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Pharmacy personnel use various techniques when compounding preparations. Which of the following best describes levigation?
Pharmacy personnel use various techniques when compounding preparations. Which of the following best describes levigation?
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What is the appropriate beyond-use date (BUD) for an oral suspension that does not have stability information on the product label?
What is the appropriate beyond-use date (BUD) for an oral suspension that does not have stability information on the product label?
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What standards must be followed during extemporaneous compounding?
What standards must be followed during extemporaneous compounding?
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Which of the following should be used in lifting pharmacy weights to be placed on a balance?
Which of the following should be used in lifting pharmacy weights to be placed on a balance?
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Which part of the liquid does one look at when measuring liquids?
Which part of the liquid does one look at when measuring liquids?
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Which of the following would be used to prepare an ointment if another technician is using the ointment slab?
Which of the following would be used to prepare an ointment if another technician is using the ointment slab?
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How often must a Class A prescription balance be certified?
How often must a Class A prescription balance be certified?
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What dosage form is prepared using the punch method?
What dosage form is prepared using the punch method?
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When a pharmacy technician is performing geometric dilution, when does she add the most potent ingredient, which usually has the smallest volume to the mortar?
When a pharmacy technician is performing geometric dilution, when does she add the most potent ingredient, which usually has the smallest volume to the mortar?
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Which of the following agents is used to increase the viscosity of a suspension?
Which of the following agents is used to increase the viscosity of a suspension?
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What type of mortar and pestle are used to mix liquids?
What type of mortar and pestle are used to mix liquids?
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Study Notes
Non-Sterile Compounding Overview
- Non-sterile compounding is addressed in USP Chapter 795.
- Compounding is the formulation of a drug preparation as per a physician's prescription specifically for an individual patient.
Storage Guidelines
- Drugs labeled "Store at 25°C" must be kept at room temperature.
- Refrigerated products must be stored between 36 to 46°F.
- Open insulin has a stability of 28 days when refrigerated.
- Calcitonin-salmon is an osteoporosis medication that requires refrigeration.
Compounding Documentation and Stability
- The compounding record details the actual ingredients and procedures used.
- The beyond-use date (BUD) for compounded preparations can be affected by the presence of water.
- For water-containing formulations made from solid ingredients, the maximum BUD is 30 days.
- Non-aqueous medications prepared on February 3, 2017, have a BUD of August 3, 2017 (six months).
Weighing and Balancing Techniques
- A minimum of 120 mg can be weighed on a Class A prescription balance to stay within the 5% margin of error.
- Powder should be weighed using a clean weigh boat for each new powder.
- Class A balances must be certified every 12 months and have a sensitivity of 6 mg.
- Maximum weighable quantity on a Class A prescription balance is 60g.
Liquid Measurement Techniques
- To measure 78 mL of liquid, use a 3-ounce graduated cylinder.
- A 100 mL graduated cylinder cannot accurately measure less than 20 mL.
- Always measure liquid at the bottom of the meniscus for accuracy.
- The phenomenon of a meniscus occurs in liquids measured in graduated cylinders.
Particle Size Reduction Techniques
- Geometric dilution is used to combine ingredients in unequal quantities.
- Rubber spatulas are recommended for measuring corrosive ingredients.
- Levigation refers to triturating a powder with an insoluble solvent to reduce particle size.
- Trituration specifically denotes the fine grinding of a powder.
Suspensions and Dosage Forms
- A thickening agent increases the viscosity of a suspension.
- Well-made suspensions settle slowly and re-disperse quickly.
- A suspension consists of solid particles dispersed in a liquid.
- Reconstitution is the process of adding water to powdered drugs, like antibiotics.
Emulsions and Other Compounding Techniques
- Emulsions can be made using the dry-gum, wet-gum, or beaker methods.
- An emulsion is suitable when compounding a liquid with an oil-based active drug and a water-based vehicle.
- Suppositories are dosage forms prepared by compression or molding.
- Capsules can contain various forms, including other capsules, bulk powders, or liquids.
General Compounding Standards and Practices
- Standards for extemporaneous compounding require adherence to Good Manufacturing Practice (GMP).
- For oral solutions prepared with water, BUD is typically 14 days.
- The appropriate BUD for oral suspensions lacking stability data is also no later than 14 days.
- Use forceps to lift weights placed on a balance.
Equipment and Measurement
- Class A prescription balances must be zeroed or recalibrated before each use.
- A glass mortar and pestle are utilized for mixing liquids.
- Parchment paper can be used to prepare ointments when an ointment slab is occupied.
Studying That Suits You
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Description
Test your knowledge on non-sterile compounding with these flashcards based on Chapter 9 of the USP. Each card focuses on important terms and definitions relevant to compounding practices, storage conditions, and individual patient formulations. Perfect for pharmacy students preparing for their exams!
