Pharmacophore Interactions in Drug-Receptor Binding

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What are the relevant groups on a molecule responsible for interacting with a receptor known as?

Receptorphore

Auxophore

Integraphore

Pharmacophore (correct)

Which atoms in the lead compound are sometimes referred to as auxophore?

Essential atoms

Pharmacophoric atoms

Interfering atoms

Additional atoms (correct)

Why is it important to identify atoms in the auxophore?

To enhance the potency of the drug

To solve pharmacokinetic problems (correct)

To improve pharmacodynamics

To ensure receptor binding

What may happen if some atoms in the auxophore are left unmodified?

Loss of potency Signup and view all the answers

What is pharmaceutical chemistry primarily focused on studying?

Physical properties of drugs Signup and view all the answers

In addition to organic and inorganic chemistry, which other branches of chemistry does pharmaceutical chemistry heavily rely on?

Analytical chemistry Signup and view all the answers

How has pharmaceutical chemistry contributed to understanding basic physiological and pathological mechanisms?

By advancing knowledge of physiology and biochemistry Signup and view all the answers

Which of the following is NOT a factor considered in pharmaceutical chemistry for the study of drugs?

Medicinal properties Signup and view all the answers

Why is a knowledge of the biological sciences essential in understanding drug treatment?

To understand the effects on various body systems Signup and view all the answers

Which scientific data forms the basis of rational drug treatment according to the text?

Data from animal and human studies Signup and view all the answers

What is the primary definition of a drug according to the World Health Organisation?

Any substance used to modify physiological systems for the benefit of the recipient Signup and view all the answers

In pharmaceutical chemistry, what does knowledge of organic and analytical chemistry help in?

Studying the molecular structure of a drug Signup and view all the answers

Which area of study is closely related to pharmaceutical chemistry according to the text?

Physics Signup and view all the answers

What are some examples of drugs derived from animal sources?

Insulin, thyroid, heparin Signup and view all the answers

Why is pharmaceutical chemistry closely related to physical and colloid chemistry?

To study molecular structure and physico-chemical properties of drugs Signup and view all the answers

What determines the action of a drug according to the text?

A combination of its chemical structure and physico-chemical properties Signup and view all the answers

Which dosage form is preferred due to being simpler to manufacture, easy to transport, and suitable for long-term storage?

Tablets Signup and view all the answers

What does pharmacology primarily deal with?

Drugs Signup and view all the answers

What is the main objective of pharmacology as mentioned in the text?

To study the mode of action of drugs Signup and view all the answers

What does medicinal chemistry focus on?

Developing new therapeutic agents Signup and view all the answers

Which branch of biology does pharmacology belong to?

Biology Signup and view all the answers

What knowledge is important for a medicinal chemist according to the text?

Organic chemistry and biological sciences Signup and view all the answers

What does pharmacodynamics study focus on?

Biological and therapeutic effects of drugs Signup and view all the answers

Which branch of study determines the site of drug action?

Molecular Pharmacology Signup and view all the answers

What is a pharmacophore?

The functional group responsible for a drug's physiological activity Signup and view all the answers

What is the primary action of antimetabolites?

Blocking cellular metabolism by resembling metabolites Signup and view all the answers

What do pharmacokinetics mainly study?

Drug metabolism and distribution in the body Signup and view all the answers

How do sulphonamides act as antimetabolites?

By blocking bacterial metabolism through structural resemblance to PABA Signup and view all the answers