Pharmacophore Interactions in Drug-Receptor Binding
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Questions and Answers

What are the relevant groups on a molecule responsible for interacting with a receptor known as?

  • Receptorphore
  • Auxophore
  • Integraphore
  • Pharmacophore (correct)

Which atoms in the lead compound are sometimes referred to as auxophore?

  • Essential atoms
  • Pharmacophoric atoms
  • Interfering atoms
  • Additional atoms (correct)

Why is it important to identify atoms in the auxophore?

  • To enhance the potency of the drug
  • To solve pharmacokinetic problems (correct)
  • To improve pharmacodynamics
  • To ensure receptor binding

What may happen if some atoms in the auxophore are left unmodified?

<p>Loss of potency (C)</p> Signup and view all the answers

What is pharmaceutical chemistry primarily focused on studying?

<p>Physical properties of drugs (A)</p> Signup and view all the answers

In addition to organic and inorganic chemistry, which other branches of chemistry does pharmaceutical chemistry heavily rely on?

<p>Analytical chemistry (A)</p> Signup and view all the answers

How has pharmaceutical chemistry contributed to understanding basic physiological and pathological mechanisms?

<p>By advancing knowledge of physiology and biochemistry (A)</p> Signup and view all the answers

Which of the following is NOT a factor considered in pharmaceutical chemistry for the study of drugs?

<p>Medicinal properties (C)</p> Signup and view all the answers

Why is a knowledge of the biological sciences essential in understanding drug treatment?

<p>To understand the effects on various body systems (A)</p> Signup and view all the answers

Which scientific data forms the basis of rational drug treatment according to the text?

<p>Data from animal and human studies (C)</p> Signup and view all the answers

What is the primary definition of a drug according to the World Health Organisation?

<p>Any substance used to modify physiological systems for the benefit of the recipient (C)</p> Signup and view all the answers

In pharmaceutical chemistry, what does knowledge of organic and analytical chemistry help in?

<p>Studying the molecular structure of a drug (A)</p> Signup and view all the answers

Which area of study is closely related to pharmaceutical chemistry according to the text?

<p>Physics (D)</p> Signup and view all the answers

What are some examples of drugs derived from animal sources?

<p>Insulin, thyroid, heparin (C)</p> Signup and view all the answers

Why is pharmaceutical chemistry closely related to physical and colloid chemistry?

<p>To study molecular structure and physico-chemical properties of drugs (A)</p> Signup and view all the answers

What determines the action of a drug according to the text?

<p>A combination of its chemical structure and physico-chemical properties (C)</p> Signup and view all the answers

Which dosage form is preferred due to being simpler to manufacture, easy to transport, and suitable for long-term storage?

<p>Tablets (B)</p> Signup and view all the answers

What does pharmacology primarily deal with?

<p>Drugs (B)</p> Signup and view all the answers

What is the main objective of pharmacology as mentioned in the text?

<p>To study the mode of action of drugs (A)</p> Signup and view all the answers

What does medicinal chemistry focus on?

<p>Developing new therapeutic agents (B)</p> Signup and view all the answers

Which branch of biology does pharmacology belong to?

<p>Biology (A)</p> Signup and view all the answers

What knowledge is important for a medicinal chemist according to the text?

<p>Organic chemistry and biological sciences (A)</p> Signup and view all the answers

What does pharmacodynamics study focus on?

<p>Biological and therapeutic effects of drugs (A)</p> Signup and view all the answers

Which branch of study determines the site of drug action?

<p>Molecular Pharmacology (D)</p> Signup and view all the answers

What is a pharmacophore?

<p>The functional group responsible for a drug's physiological activity (A)</p> Signup and view all the answers

What is the primary action of antimetabolites?

<p>Blocking cellular metabolism by resembling metabolites (C)</p> Signup and view all the answers

What do pharmacokinetics mainly study?

<p>Drug metabolism and distribution in the body (A)</p> Signup and view all the answers

How do sulphonamides act as antimetabolites?

<p>By blocking bacterial metabolism through structural resemblance to PABA (A)</p> Signup and view all the answers

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