Pharmacology Terminology and Drug Sources
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Questions and Answers

What does the term 'pharmacokinetics' primarily relate to in pharmacology?

  • The methods of drug delivery to patients
  • The effects of drugs on biological systems
  • The chemical structure of drugs
  • The processes of absorption, distribution, metabolism, and excretion (correct)

Which of the following is a primary mode of drug absorption in the body?

  • Excretion through renal pathways
  • Endocytosis into target cells
  • Passive diffusion through lipid bilayers (correct)
  • Active transport through cell membranes

Which term accurately describes the bioavailability of a drug?

  • The effect a drug has on target tissues
  • The rate at which a drug is excreted from the body
  • The extent to which a drug binds to plasma proteins
  • The proportion of a drug that enters systemic circulation intact (correct)

What is typically the main source of pharmacological drugs?

<p>Natural products and synthesized compounds (C)</p> Signup and view all the answers

Which of the following describes the 'distribution' phase of pharmacokinetics?

<p>The transport of drugs throughout the body fluids and tissues (A)</p> Signup and view all the answers

What does facilitated diffusion primarily involve in terms of transport mechanisms?

<p>Movement along the concentration gradient via carrier proteins (A)</p> Signup and view all the answers

In the context of drug passage, what role do protein carriers play in facilitated diffusion?

<p>They facilitate the movement of molecules across membranes along the concentration gradient. (C)</p> Signup and view all the answers

Which of the following is a characteristic of facilitated diffusion that differentiates it from simple diffusion?

<p>It requires specific protein carriers for substance movement. (D)</p> Signup and view all the answers

What is the primary difference between facilitated diffusion and active transport?

<p>Active transport involves movement against the concentration gradient, while facilitated diffusion does not. (B)</p> Signup and view all the answers

Which substance is specifically mentioned in relation to facilitated diffusion in the context provided?

<p>Urea (D)</p> Signup and view all the answers

Which of the following compounds is associated with active transport mechanisms in the intestinal lumen?

<p>5-fluoro-uracil (B), Levodopa (D)</p> Signup and view all the answers

Which substance is considered a higher concentration in the context of active transport?

<p>Body nutrients (B)</p> Signup and view all the answers

What role does the carrier play in active transport across the apical cell membrane?

<p>It binds to the drug for movement (A)</p> Signup and view all the answers

Which of the following is NOT an example of a substance that undergoes active transport?

<p>Dextrose (D)</p> Signup and view all the answers

Which compound is primarily involved in metabolic processes rather than active transport?

<p>ATP (D)</p> Signup and view all the answers

What role does particle size play in drug absorption?

<p>Small particle sizes are critical for improving drug absorption. (D)</p> Signup and view all the answers

Which of the following statements about drug dosage forms is accurate?

<p>Drugs in a dispersed or emulsified state have better absorption capabilities. (A)</p> Signup and view all the answers

What aspects are crucial for the effectiveness of a drug's dosage form?

<p>Disintegration time and dissolution rate. (D)</p> Signup and view all the answers

Which vitamins are highlighted for having better absorption in a dispersed or emulsified state?

<p>Vitamin D and Vitamin A. (A)</p> Signup and view all the answers

Why is disintegration time important in dosage forms?

<p>It determines how quickly a drug can be absorbed in the body. (A)</p> Signup and view all the answers

What is the primary purpose of endocytosis in a cell?

<p>To engulf large molecules and release them intracellularly (D)</p> Signup and view all the answers

Which of the following substances are known to be taken up through endocytosis?

<p>Proteins and toxins such as botulinum and diphtheria (B)</p> Signup and view all the answers

In which scenario would endocytosis most likely occur?

<p>When a cell encounters large macromolecules or pathogens (A)</p> Signup and view all the answers

How does the cell membrane change during endocytosis?

<p>It invaginates to form a vesicle that engulfs the material (A)</p> Signup and view all the answers

What types of molecules are least likely to be involved in the process of endocytosis?

<p>Small inorganic ions (B)</p> Signup and view all the answers

Intravenous administration means that the drug bypasses absorption and enters circulation directly.

<p>True (A)</p> Signup and view all the answers

Biotransport refers to the process of a drug being distributed evenly across all bodily tissues.

<p>False (B)</p> Signup and view all the answers

Intra-arterial administration allows for the direct entry of drugs into systemic circulation without prior absorption.

<p>True (A)</p> Signup and view all the answers

The term 'biotransport' is synonymous with the drug's metabolic breakdown in the liver.

<p>False (B)</p> Signup and view all the answers

Drugs administered via injection avoid the complex processes of absorption seen with oral medications.

<p>True (A)</p> Signup and view all the answers

Absorption and first pass metabolism are unaffected in liver cirrhosis.

<p>False (B)</p> Signup and view all the answers

Conditions such as achlorhydria can impact drug absorption.

<p>True (A)</p> Signup and view all the answers

Thyrotoxicosis has no effect on drug metabolism processes.

<p>False (B)</p> Signup and view all the answers

Malabsorption syndromes can lead to reduced bioavailability of drugs.

<p>True (A)</p> Signup and view all the answers

All disease states have the same impact on absorption and metabolism.

<p>False (B)</p> Signup and view all the answers

Filtration allows large molecules to cross the plasma membrane through pores as a result of hydrodynamic pressure gradient.

<p>False (B)</p> Signup and view all the answers

Hydrodynamic pressure is essential for the process of filtration across the plasma membrane.

<p>True (A)</p> Signup and view all the answers

Pores in the plasma membrane allow the passage of both soluble and insoluble drugs during the filtration process.

<p>False (B)</p> Signup and view all the answers

The process of filtration is exclusive to the transport of blood proteins across the plasma membrane.

<p>False (B)</p> Signup and view all the answers

The molecular weight of drugs plays a crucial role in their ability to cross the plasma membrane through filtration.

<p>True (A)</p> Signup and view all the answers

Bisacodyl laxatives are typically administered via the parenteral route exclusively through IV.

<p>False (B)</p> Signup and view all the answers

The intravenous route of drug administration provides immediate availability of the drug to the bloodstream.

<p>True (A)</p> Signup and view all the answers

Intramuscular and subcutaneous routes depend on vascular system perfusion for drug absorption.

<p>True (A)</p> Signup and view all the answers

Rectal suppositories are solely used for laxative purposes and cannot be involved in other types of drug deliveries.

<p>False (B)</p> Signup and view all the answers

IM and SC routes are always faster than IV administration for drug absorption.

<p>False (B)</p> Signup and view all the answers

Disintegration time refers to the speed at which the drug granules dissolve in a liquid.

<p>False (B)</p> Signup and view all the answers

The dissolution rate measures how quickly the drug enters solution after disintegration.

<p>True (A)</p> Signup and view all the answers

A longer disintegration time generally leads to a faster dissolution rate for tablets.

<p>False (B)</p> Signup and view all the answers

Both disintegration time and dissolution rate are crucial for determining a drug's bioavailability.

<p>True (A)</p> Signup and view all the answers

Dissolution rate is unrelated to the effectiveness of a drug's therapeutic action.

<p>False (B)</p> Signup and view all the answers

What is the primary goal of clinical pharmacology?

<p>To evaluate the pharmacological action of drugs, preferred routes of administration, and safe dosage ranges in humans through clinical trials.</p> Signup and view all the answers

How does the method of administration impact drug pharmacokinetics?

<p>Different methods of administration affect the drug's absorption rate, bioavailability, and overall therapeutic effects.</p> Signup and view all the answers

Why is the study of pharmacodynamics important in clinical pharmacology?

<p>Pharmacodynamics helps determine the effects of drugs on the body and the relationship between drug concentration and its therapeutic effect.</p> Signup and view all the answers

Explain the significance of safe dosage ranges in clinical trials.

<p>Safe dosage ranges are critical to prevent toxicity and adverse effects while ensuring therapeutic effectiveness during drug administration.</p> Signup and view all the answers

What is the role of clinical trials in evaluating drug administration routes?

<p>Clinical trials assess different drug administration routes to determine the most effective and safest ways to deliver treatments to patients.</p> Signup and view all the answers

What is the role of food in the gastrointestinal tract concerning drug absorption?

<p>Food can aid in the absorption of certain drugs, such as griseofulvin and propranolol.</p> Signup and view all the answers

How does Vitamin C influence the absorption of iron in the gastrointestinal tract?

<p>Vitamin C enhances the absorption of iron from the G.I.T.</p> Signup and view all the answers

Can the absorption of riboflavin be affected by the presence of food? Explain why.

<p>Yes, the presence of food can aid in the absorption of riboflavin.</p> Signup and view all the answers

List one example of a drug whose absorption is positively influenced by food intake.

<p>Griseofulvin.</p> Signup and view all the answers

What can be inferred about the interaction between food and drug absorption based on the information provided?

<p>Food can have a positive impact on the absorption of certain drugs and nutrients.</p> Signup and view all the answers

What factors can significantly impact the bioavailability of a drug when administered orally?

<p>Factors include the physico-chemical properties of the drug, the nature of the dosage form, physiological factors, pharmacogenetic factors, and disease states.</p> Signup and view all the answers

What is the primary focus of pharmacodynamics in relation to drug effects on the body?

<p>Pharmacodynamics primarily focuses on the biological and therapeutic effects of drugs, exploring 'what the drug does to the body'.</p> Signup and view all the answers

Explain how the bioavailability formula is calculated for a drug taken orally compared to an intravenous dose.

<p>The bioavailability (F) is calculated by dividing the area under the curve (AUC) after oral dosing by the AUC after intravenous dosing.</p> Signup and view all the answers

Identify two sources from which drugs can be derived, as mentioned in the study of pharmacodynamics.

<p>Drugs can be obtained from minerals, such as liquid paraffin and magnesium sulfate.</p> Signup and view all the answers

Discuss the importance of physicochemical properties of a drug in relation to its absorption.

<p>Physicochemical properties such as solubility, pH, and molecular weight significantly influence how well a drug dissolves and is absorbed in the gastrointestinal tract.</p> Signup and view all the answers

What is the significance of disintegration time in relation to a drug's bioavailability?

<p>Disintegration time is significant as it affects how quickly a drug dissolves and thus influences its absorption and bioavailability.</p> Signup and view all the answers

What role do pharmacogenetic factors play in drug absorption and bioavailability?

<p>Pharmacogenetic factors can alter the metabolism and response to drugs, affecting both the rate and extent of drug absorption.</p> Signup and view all the answers

How does the molecular weight of drugs impact their ability to cross the plasma membrane via filtration?

<p>The molecular weight of drugs affects their ability to cross the plasma membrane; larger molecules may struggle to pass through filtration pores.</p> Signup and view all the answers

How can disease states influence the bioavailability of pharmaceuticals?

<p>Disease states can affect gastric pH, gastrointestinal motility, and blood flow, leading to changes in drug absorption and overall bioavailability.</p> Signup and view all the answers

Explain how intravenous administration of drugs contrasts with oral medication in terms of absorption processes.

<p>Intravenous administration bypasses the complex absorption processes seen with oral medications, allowing for immediate availability of the drug in the bloodstream.</p> Signup and view all the answers

How does first pass metabolism affect the efficacy of orally administered drugs?

<p>First pass metabolism can significantly reduce the bioavailability of orally administered drugs, limiting their effectiveness before they reach systemic circulation.</p> Signup and view all the answers

What role do pharmacogenetic factors play in drug absorption and response?

<p>Pharmacogenetic factors lead to individual variations in drug absorption and response due to genetic differences in metabolic enzymes and transport proteins.</p> Signup and view all the answers

In what way can a drug with high oral absorption still be ineffective?

<p>A drug can be ineffective despite high oral absorption if it undergoes extensive first pass metabolism, resulting in little to no active drug reaching systemic circulation.</p> Signup and view all the answers

Can liver cirrhosis impact first pass metabolism, and if so, how?

<p>Yes, liver cirrhosis can impair first pass metabolism, potentially increasing the bioavailability of certain drugs and affecting their therapeutic effects.</p> Signup and view all the answers

What implications do malabsorption syndromes have on drug bioavailability?

<p>Malabsorption syndromes can lead to reduced bioavailability of drugs, as they hinder the effective absorption of substances in the gastrointestinal tract.</p> Signup and view all the answers

Drugs are chemical substances that alter the body's function by interactions at the ______ level.

<p>molecular</p> Signup and view all the answers

Filtration allows large molecules to cross the plasma membrane through ______ as a result of hydrodynamic pressure gradient.

<p>pores</p> Signup and view all the answers

The ______ route of drug administration provides immediate availability of the drug to the bloodstream.

<p>intravenous</p> Signup and view all the answers

A longer disintegration time generally leads to a faster ______ rate for tablets.

<p>dissolution</p> Signup and view all the answers

Conditions such as ______ can impact drug absorption.

<p>achlorhydria</p> Signup and view all the answers

Pinocytosis is a process that primarily involves the cell membrane engulfing ______ from the environment.

<p>liquid</p> Signup and view all the answers

In drug absorption, the concentration difference between the intestinal lumen and the cell ______ is essential for the movement of drugs.

<p>interior</p> Signup and view all the answers

The vacuole formed during pinocytosis contains ______ that the cell has absorbed.

<p>fluid</p> Signup and view all the answers

In the process of pinocytosis, substances are taken up from areas of ______ concentration to areas of lower concentration.

<p>high</p> Signup and view all the answers

Pinocytosis is ______ important for drug absorption compared to other mechanisms.

<p>not</p> Signup and view all the answers

The rate and amount of drug that is absorbed and reaches systemic circulation is known as ______.

<p>bioavailability</p> Signup and view all the answers

When a drug is administered intravenously (IV), its bioavailability is ______%.

<p>100</p> Signup and view all the answers

Bioavailability is particularly relevant for drugs that are administered via ______ routes.

<p>non-vascular</p> Signup and view all the answers

The ______ administration method ensures that the drug bypasses the absorption process.

<p>intravenous</p> Signup and view all the answers

The systemic circulation is the pathway through which the drug is distributed throughout the ______.

<p>body</p> Signup and view all the answers

Usually substances like lactose, sucrose, starch, and calcium ______ are used as inert diluents in formulating powders or tablets.

<p>phosphate</p> Signup and view all the answers

Substances such as lactose and ______ are often utilized in the formulation of tablets.

<p>sucrose</p> Signup and view all the answers

Inert diluents like starch help improve the ______ properties of pharmaceutical powders and tablets.

<p>formulation</p> Signup and view all the answers

For creating tablets, substances such as lactose, sucrose, and ______ are important due to their inert nature.

<p>calcium phosphate</p> Signup and view all the answers

In formulating powders, ______ is commonly listed alongside lactose and starch as an inert diluent.

<p>sucrose</p> Signup and view all the answers

Rapid absorption occurs when the drug is given on an empty ______.

<p>stomach</p> Signup and view all the answers

Certain irritant drugs like salicylates and iron preparations are administered after ______ to minimize gastrointestinal irritation.

<p>food</p> Signup and view all the answers

Gastrointestinal transit time affects the rate of ______ for drugs.

<p>absorption</p> Signup and view all the answers

Drugs that cause ______ irritation are often taken with food to reduce side effects.

<p>gastrointestinal</p> Signup and view all the answers

Administration of drugs on an empty stomach typically results in ______ absorption.

<p>rapid</p> Signup and view all the answers

Match the following antibiotics with their primary sources:

<p>Penicillin = Microorganisms Streptomycin = Microorganisms Ampicillin = Synthetic Ciprofloxacin = Synthetic</p> Signup and view all the answers

Match the following products with their categories in genetic engineering:

<p>Human insulin = Hormonal therapy Human growth hormone = Hormonal therapy Recombinant vaccines = Preventive medicine Gene therapy products = Experimental treatments</p> Signup and view all the answers

Match the following drug types with their characteristics:

<p>Synthetic drugs = Majority of current therapeutics Natural antibiotics = Derived from microorganisms Biological drugs = Produced through genetic engineering Synthetic opioids = Man-made pain relief</p> Signup and view all the answers

Match the following antibiotic classes with their functions:

<p>Beta-lactams = Bacterial cell wall synthesis inhibitors Aminoglycosides = Protein synthesis inhibitors Macrolides = Bacterial ribosome targeters Tetracyclines = Broad-spectrum antibiotics</p> Signup and view all the answers

Match the following terms with their definitions:

<p>Antibiotic = Substance that kills bacteria or inhibits their growth Hormone = Chemical messenger produced by glands Bioavailability = Fraction of an administered dose that reaches systemic circulation Genetic engineering = Manipulation of an organism's genetic material</p> Signup and view all the answers

Match the following terms related to pharmacodynamics with their correct definitions:

<p>Pharmacodynamics = The study of what the drug does to the body Bioavailability = The degree and rate at which a drug is absorbed and becomes available at the site of action Therapeutic Effects = The intended beneficial effects of a drug Toxic Effects = Harmful effects caused by excessive drug exposure</p> Signup and view all the answers

Match the following drug sources with their respective examples:

<p>Minerals = Magnesium sulfate Plants = Digitalis Animals = Insulin from porcine sources Synthetics = Ibuprofen</p> Signup and view all the answers

Match the following terms with their related drug administration methods:

<p>Intravenous = Direct entry into circulation Intramuscular = Absorption depends on vascular system perfusion Rectal = Used for both local and systemic effects Subcutaneous = Injection into the tissue just beneath the skin</p> Signup and view all the answers

Match the following concepts with their correct descriptions in drug absorption:

<p>Disintegration = The process of breaking down a drug into smaller particles Dissolution = How quickly the drug enters solution after disintegration Active Transport = The movement of drugs against a concentration gradient using energy Facilitated Diffusion = The passive movement of drugs across the cell membrane through a protein transporter</p> Signup and view all the answers

Match the following pharmacological effects with their implications:

<p>Malabsorption Syndromes = Can lead to reduced bioavailability of drugs Thyrotoxicosis = May affect drug metabolism processes Filtration = Allows large molecules to cross membranes due to pressure gradients Endocytosis = Enables the uptake of extracellular substances into the cell</p> Signup and view all the answers

Match the following drug administration routes with their characteristics:

<p>Intravenous = Bypasses absorption, enters bloodstream directly Intramuscular = Absorption depends on vascular perfusion Subcutaneous = Utilizes the fatty tissue layer for absorption Rectal suppositories = Can be used for various drug deliveries, not just laxatives</p> Signup and view all the answers

Match the pharmacological concepts with their definitions:

<p>Biotransport = Distribution of drugs across all bodily tissues Filtration = Crossing of the plasma membrane via hydrodynamic pressure gradient Dissolution rate = Speed at which the drug enters solution after disintegration Disintegration time = Time taken for drug granules to dissolve in a liquid</p> Signup and view all the answers

Match the conditions that can impact drug metabolism with their effects:

<p>Liver cirrhosis = Affects absorption and first pass metabolism Achlorhydria = Impacts drug absorption Thyrotoxicosis = Has no effect on drug metabolism processes Malabsorption syndromes = Leads to reduced bioavailability of drugs</p> Signup and view all the answers

Match the terms related to drug absorption with their correct descriptions:

<p>Active transport = Involves protein carriers for drug passage Facilitated diffusion = Occurs without energy expenditure Simple diffusion = Passive movement through membrane concentration gradient Endocytosis = Involves cell membrane engulfing substances</p> Signup and view all the answers

Match the statements regarding drug effectiveness with the appropriate concepts:

<p>Disintegration time = Important for determining bioavailability Dissolution rate = Measures the effectiveness of drug therapeutic action Higher concentration = Substance involved in active transport processes Filtration process = Exclusively transports blood proteins through plasma membrane</p> Signup and view all the answers

Match the type of drug administration with its description:

<p>Intravenous = Bypasses absorption and enters circulation directly Intra-arterial = Allows for direct entry into systemic circulation Oral = Requires absorption processes before entering circulation Intramuscular = Depends on vascular system perfusion for absorption</p> Signup and view all the answers

Match the term with its appropriate definition:

<p>Biotransport = Translocation of a solute across a biological barrier Absorption = Process by which drugs enter the bloodstream Dissolution rate = Speed at which a drug enters solution after disintegration Disintegration time = Speed at which drug granules dissolve in a liquid</p> Signup and view all the answers

Match the condition affecting drug absorption with its impact:

<p>Achlorhydria = Can impact drug absorption negatively Thyrotoxicosis = Has no effect on drug metabolism processes Malabsorption syndromes = Lead to reduced bioavailability of drugs Liver cirrhosis = Does not affect absorption and first pass metabolism</p> Signup and view all the answers

Match the process related to drug transport with its characteristic:

<p>Filtration = Allows large molecules to cross the plasma membrane Endocytosis = Cell membrane invagination to take up substances Active transport = Requires energy to move substances against a gradient Facilitated diffusion = Involves carrier proteins but no energy expenditure</p> Signup and view all the answers

Match the aspect of drug dosage form with its significance:

<p>Disintegration time = Affects the rate of drug release Dissolution rate = Determines the speed of drug absorption Bioavailability = Indicates the extent and rate at which the active ingredient is absorbed Serum concentration = Reflects the drug's effectiveness in the bloodstream</p> Signup and view all the answers

Match the following aspects of drug absorption with their correct descriptions:

<p>Surface area of the intestine = Increases drug absorption due to larger area Vascular supply = Enhances absorption through increased blood flow Small intestine = Preferred site for drug absorption over the stomach Stomach = Has a smaller area for drug absorption compared to the intestine</p> Signup and view all the answers

Match the following factors affecting drug absorption with their corresponding effects:

<p>Increased surface area = Leads to better absorption rates Increased vascularity = Improves drug distribution Malabsorption syndromes = Results in reduced bioavailability Achlorhydria = Impacts the absorption negatively</p> Signup and view all the answers

Match the following routes or methods of drug administration with their characteristics:

<p>Intravenous administration = Bypasses absorption and directly enters circulation Intramuscular administration = Depends on blood supply for absorption Oral administration = Involves complex absorption processes Rectal suppositories = Not limited to laxative purposes only</p> Signup and view all the answers

Match the following conditions related to drug absorption with their consequences:

<p>Liver cirrhosis = Can affect first-pass metabolism Thyrotoxicosis = Does not impact metabolic processes Dissolution rate = Affects how quickly a drug enters solution Disintegration time = Determines the rate of granule dissolution</p> Signup and view all the answers

Match the following terms associated with pharmacology to their definitions:

<p>Filtration = Allows passage of molecules based on size and pressure Biotransport = Describes the distribution of drugs across tissues Dissolution rate = Measures the speed at which a drug dissolves Disintegration time = Refers to how quickly drug granules yield to liquid</p> Signup and view all the answers

Study Notes

Terminology in Pharmacology

  • Pharmacology involves the study of drug action and the interaction between drugs and living organisms.
  • Key terms include pharmacodynamics (drug action effects), pharmacokinetics (drug absorption, distribution, metabolism, excretion), and pharmacotherapy (treatment with drugs).

Nature and Sources of Drugs

  • Drugs originate from natural sources (plants, animals, minerals) and synthetic processes.
  • Natural sources include herbs (e.g., morphine from opium poppy), animal products (e.g., insulin from pancreas), and minerals (e.g., lithium from mineral deposits).
  • Synthetic drugs are chemically manufactured to create specific therapeutic effects.

Pharmacokinetics - ADME

  • Absorption: Process by which drugs enter the bloodstream; influenced by route of administration and dosage form.
  • Distribution: Movement of drugs throughout the body, affected by factors like blood flow and tissue permeability.
  • Metabolism: Biochemical modification of drugs primarily occurring in the liver; converts lipophilic drug molecules into more polar compounds.
  • Excretion: Removal of drugs from the body, mainly through urine and feces; can also occur via breath and sweat.

Facilitated Diffusion

  • Facilitated diffusion allows drugs to pass through biological membranes along the concentration gradient using protein carriers.
  • It is energy-efficient and specific to certain molecules.
  • Commonly involves drugs like alpha-methyl dopa, levodopa, 5-fluoro-uracil, and 5-bromouracil.

Active Transport

  • Active transport is the movement of substances against their concentration gradient, requiring energy (ATP).
  • Essential for transporting nutrients and certain drugs like riboflavin and amino acids across cell membranes.

Endocytosis

  • Endocytosis engulfs large molecules via cell membrane, allowing intracellular release.
  • Commonly occurs with proteins and toxins, such as botulinum and diphtheria toxin.

Dosage Forms and Particle Size

  • Particle size affects drug absorption; smaller particles enhance bioavailability.
  • Drugs in dispersed or emulsified forms (e.g., vitamin D, vitamin A) exhibit improved absorption rates.
  • Disintegration time and dissolution rate are critical for effective drug release and activity.

Rectal Suppositories and Laxatives

  • Bisacodyl is a common laxative administered rectally to relieve constipation.

Parenteral Drug Administration

  • Common routes include intravenous (IV), intramuscular (IM), and subcutaneous (SC).
  • IV administration allows for immediate drug availability in the bloodstream.
  • IM and SC routes depend on adequate vascular perfusion for drug absorption.

Intravenous and Intra-arterial Administration

  • Directly delivers the drug into circulation, bypassing traditional absorption processes.

Biotransport of Drugs

  • Refers to the translocation of solutes across biological barriers from one side to another.

Filtration Process

  • Water-soluble drugs of low molecular weight cross cell membranes via pores due to hydrodynamic pressure gradients.

Disintegration and Dissolution Rates

  • Disintegration time measures how quickly a tablet or capsule breaks into drug granules.
  • Dissolution rate refers to how fast the drug dissolves into solution after disintegration.

Effects of Disease States on Absorption and Metabolism

  • Conditions such as malabsorption, thyrotoxicosis, achlorhydria, and liver cirrhosis can impair drug absorption and first-pass metabolism.

Pharmacology Overview

  • Pharmaco- refers to medicine, while -logia indicates study, collectively representing the study of drugs and their effects.

Clinical Pharmacology

  • Evaluates the pharmacological action of drugs, their preferred routes of administration, and safe dosage ranges through clinical trials.

Pharmacodynamics

  • Focuses on the biological and therapeutic effects of drugs, answering "what the drug does to the body."

Sources of Drugs

  • Minerals: Common drugs derived from minerals include liquid paraffin, magnesium sulfate, and magnesium trisilicate.

Bioavailability Calculation

  • Bioavailability (F) is calculated using the formula:
    Bioavailability (F) = AUC after oral dose / AUC after I.V. dose

Factors Affecting Drug Absorption and Bioavailability

  • Physico-Chemical Properties: Characteristics of the drug itself can influence absorption.
  • Nature of Dosage Form: The form in which the drug is administered impacts its absorption efficiency.
  • Physiological Factors: Body conditions and processes can affect how a drug is absorbed.
  • Pharmacogenetic Factors: Genetic variations can lead to differences in drug absorption and response among individuals.
  • Disease States: Certain health conditions can alter drug metabolism and effectiveness.

Food Interaction

  • Food presence in the gastrointestinal (G.I.) tract can enhance absorption for specific drugs, such as griseofulvin, propranolol, and riboflavin.
  • Presence of Other Agents: Vitamin C can improve the absorption of iron from the G.I. tract.

First-Pass Metabolism

  • A drug that is well absorbed orally may still be ineffective due to extensive first-pass metabolism by the liver, reducing its bioavailable concentration.

Drugs

  • Chemical substances that modify body function through molecular interactions.
  • Introduced into the body; effects are determined by their chemical nature and dosage.

Pinocytosis

  • A cellular process involving the ingestion of liquid into cells.
  • Involves the absorption gradient from high concentration (intestinal lumen) to lower concentration (cell interior).
  • Vacuole formation occurs as the drug is internalized.
  • Not a significant mechanism for drug absorption in most cases.

Bioavailability

  • Defined as the rate and extent to which an active ingredient or active moiety is absorbed and becomes available in the systemic circulation.
  • Intravenous (IV) administration yields 100% bioavailability.
  • Influenced by various factors including formulation and physiological conditions.

Formulation

  • Inert diluents often used include lactose, sucrose, starch, and calcium phosphate.
  • These substances help in creating powders or tablets to facilitate drug administration.

Physiological Factors

  • Gastrointestinal transit time significantly affects drug absorption rates.
  • Rapid absorption occurs on an empty stomach for most drugs.
  • Certain irritant drugs (e.g., salicylates, iron preparations) are typically administered with food to reduce gastrointestinal irritation.

Introduction to Pharmacology

  • Pharmacodynamics: Examines the biological and therapeutic effects of drugs, specifically what drugs do to the body.
  • Sources of Drugs:
    • Minerals: Examples include liquid paraffin, magnesium sulfate, and magnesium trisilicate.
    • Microorganisms: Penicillin and streptomycin are prominent examples among many antibiotics.
    • Genetic Engineering: Key products include human insulin and human growth hormone.
  • Synthetic Drugs: The majority of therapeutic drugs used today are derived from synthetic sources.
  • Administration Routes:
    • Intravenous/Intra-arterial: In these cases, drugs circumvent absorption processes and enter circulation directly.
  • Biotransport of Drugs:
    • Refers to the movement of a solute across a biological barrier from one side to another.
  • Absorption Factors:
    • The area of the absorbing surface: Drugs are more effectively absorbed from the small intestine than the stomach due to its larger surface area.
    • Local Circulation: Enhanced vascular supply can lead to improved drug absorption.

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Explore key terms and concepts in pharmacology, covering pharmacodynamics, pharmacokinetics, and pharmacotherapy. Learn about the natural and synthetic sources of drugs, and understand the ADME process in drug interaction. This quiz is designed to enhance your understanding of pharmacological principles.

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